2986647-41-8
2986647-41-8
Chemical Structure
CRM1 degrader 1
- CAS No.: 2986647-41-8
- Formula:C16H20O3
- Molecular Weight:260.33
IUPAC Name: ethyl 6-bromo-3-iodoimidazo[1,2-a]pyridine-2-carboxylate
InChIKey: CHFFVRWPHNFFIX-CYBMUJFWSA-N
SMILES: CC1=CC(OC[C@H]2CC=CC(O2)=O)=C(C=C1)C(C)C
Biological Activity: CRM1 degrader 1 is a CRM1 degrader. CRM1 degrader 1 induces mitochondrial pathway-mediated apoptosis. CRM1 degrader 1 dose-dependently reduces CRM1 protein levels via the ubiquitin-proteasome pathway, promotes nuclear accumulation of p53, and regulates Bcl-2 family proteins and caspase activation. CRM1 degrader 1 is applicable to gastric cancer-related research[1].
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CRM1 degrader 1 | CRM1 degrader 1 is a CRM1 degrader. CRM1 degrader 1 induces mitochondrial pathway-mediated apoptosis. CRM1 degrader 1 dose-dependently reduces CRM1 protein levels via the ubiquitin-proteasome pathway, promotes nuclear accumulation of p53, and regulates Bcl-2 family proteins and caspase activation. CRM1 degrader 1 is applicable to gastric cancer-related research. | |||||||||||||||||||||
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