2. Membrane Transporter/Ion Channel
  3. CRM1
  4. (E)-Selinexor

(E)-Selinexor ((E)-KPT-330) is the E-isomer of Selinexor (HY-17536). Selinexor is the selective, orally active CRM1 inhibitor.

For research use only. We do not sell to patients.

(E)-Selinexor

(E)-Selinexor Chemical Structure

CAS No. : 1421923-86-5

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Based on 1 publication(s) in Google Scholar

(E)-Selinexor Related Antibodies

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Description

(E)-Selinexor ((E)-KPT-330) is the E-isomer of Selinexor (HY-17536). Selinexor is the selective, orally active CRM1 inhibitor[1].

Molecular Weight

443.31

Formula

C17H11F6N7O
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(NNC1=NC=CN=C1)/C=C/N2N=C(C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)N=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (112.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2558 mL 11.2788 mL 22.5576 mL
5 mM 0.4512 mL 2.2558 mL 4.5115 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2558 mL 11.2788 mL 22.5576 mL 56.3939 mL
5 mM 0.4512 mL 2.2558 mL 4.5115 mL 11.2788 mL
10 mM 0.2256 mL 1.1279 mL 2.2558 mL 5.6394 mL
15 mM 0.1504 mL 0.7519 mL 1.5038 mL 3.7596 mL
20 mM 0.1128 mL 0.5639 mL 1.1279 mL 2.8197 mL
25 mM 0.0902 mL 0.4512 mL 0.9023 mL 2.2558 mL
30 mM 0.0752 mL 0.3760 mL 0.7519 mL 1.8798 mL
40 mM 0.0564 mL 0.2820 mL 0.5639 mL 1.4098 mL
50 mM 0.0451 mL 0.2256 mL 0.4512 mL 1.1279 mL
60 mM 0.0376 mL 0.1880 mL 0.3760 mL 0.9399 mL
80 mM 0.0282 mL 0.1410 mL 0.2820 mL 0.7049 mL
100 mM 0.0226 mL 0.1128 mL 0.2256 mL 0.5639 mL
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(E)-Selinexor Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(E)-Selinexor1421923-86-5(E)-KPT-330CRM1Chromosomal Maintenance 1Exportin 1XPO1Inhibitorinhibitorinhibit

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