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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
5 Results for "
CW-2
" in MedChemExpress (MCE) Product Catalog:
Products (5)
5 Results for "CW-2" in MCE Product Catalog:
Cat. No.: HY-173437
CW-2 is a CRBN-recruited PARP1 PROTAC degrader. CW-2 triggers multiple downstream biological effects including DNA damage accumulation, impaired DNA repair, mitochondrial-mediated apoptosis, intracellular ROS buildup and G1/S cell cycle arrest, as well as the regulation of oxidative phosphorylation, p53, PI3K-Akt and MAPK alongside ubiquitin proteolysis pathways. CW-2 enhances cell membrane permeability and intracellular platinum enrichment, exhibits detectable pharmacokinetic profiles after intraperitoneal administration in rats and drives differential gene expression. CW-2 can be applied to research on triple-negative breast cancer, non-small cell lung cancer, cisplatin-resistant non-small cell lung cancer, colon cancer and pancreatic cancer .
Cat. No.: HY-173439
CAS No.: 2387496-31-1
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CRBN ligand-907 is a CRBN ligand, which can be used for the synthesis of PROTACs, such as CW-2 (HY-173437) .
Cat. No.: HY-173441
CAS No.: 3088771-63-2
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PARP1 ligand-1 is a PARP1 ligand, which can be used for the synthesis of PROTACs, such as CW-2 (HY-173437) .
Cat. No.: HY-173442
CAS No.: 3114223-14-9
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PARP1 Ligand-linker Conjugate-1 is a PARP1 ligand-linker conjugate that can be used for the synthesis of PROTACs, such as CW-2 (HY-173437) .
Cat. No.: HY-173440
CAS No.: 3114223-12-7
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Methyl 2-(2-aminoacetamido)-3-(4-(prop-2-yn-1-yloxy)phenyl)propanoate is a PROTAC linker that can be used for the synthesis of PROTACs, such as CW-2 (HY-173437) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
