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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
6 Results for "
CW-2
" in MedChemExpress (MCE) Product Catalog:
Products (6)
6 Results for "CW-2" in MCE Product Catalog:
3
3 Cited Publications
Synonyms: RP-3500; ATR inhibitor 4
Camonsertib (RP-3500) is an orally active, selective ATR kinase inhibitor (ATRi) with an IC50 of 1.00 nM in biochemical assays. Camonsertib shows 30-fold selectivity for ATR over mTOR (IC50=120 nM) and >2,000-fold selectivity over ATM, DNA-PK, and PI3Kα kinases. Camonsertib has potent antitumor activity .
Art. -Nr.: HY-173437
Target:
Forschungsgebiete:
CW-2 is a PARP1 PROTAC degrader. CW-2 has potent antiproliferative effects against MDA-MB-231 cells (IC50 = 0.72 μM) and CDDP-resistant cells (A549/CDDP: IC50 = 3.52 μM). CW-2 has synergistic antitumor activity and enhanced membrane permeability. CW-2 exerts antitumor effects by inducing DNA damage, impairing DNA repair, and activating mitochondria-dependent apoptosis (Pink: PARP1 ligand (HY-173441); Blue: E3 CRBN ligand (HY-173439); Black: linker (HY-173440)) .
Art. -Nr.: HY-173439
CAS. Nr.: 2387496-31-1
Target:
Forschungsgebiete:
CRBN ligand-907 is a CRBN ligand, which can be used for the synthesis of PROTACs, such as CW-2 (HY-173437) .
Art. -Nr.: HY-173441
CAS. Nr.: 3088771-63-2
Forschungsgebiete:
PARP1 ligand-1 is a PARP1 ligand, which can be used for the synthesis of PROTACs, such as CW-2 (HY-173437) .
Art. -Nr.: HY-173442
CAS. Nr.: 3114223-14-9
Forschungsgebiete:
PARP1 Ligand-linker Conjugate-1 is a PARP1 ligand-linker conjugate that can be used for the synthesis of PROTACs, such as CW-2 (HY-173437) .
Art. -Nr.: HY-173440
CAS. Nr.: 3114223-12-7
Target:
Forschungsgebiete:
Methyl 2-(2-aminoacetamido)-3-(4-(prop-2-yn-1-yloxy)phenyl)propanoate is a PROTAC linker that can be used for the synthesis of PROTACs, such as CW-2 (HY-173437) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
