1 Result for "

Cetrelimab

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "Cetrelimab" in MCE Product Catalog:

Cetrelimab
Cetrelimab
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Cat. No.: HY-P99499
CAS No.: 2050478-92-5
Synonyms: JNJ 63723283; JNJ 3283

Target:  

PD-1/PD-L1 Interleukin Related TNF Receptor

Research Areas:  

Cancer

Cetrelimab (JNJ 63723283; JNJ 3283) is a human IgG4κ mAb targeting PD-1. Cetrelimab binds PD-1 (Kd=1.72 nM, HEK293) to block the interaction of PD-1 with PD-L1 and PD-L2 (IC50s=111.7 ng/mL and 138.6 ng/mL, respectively). Cetrelimab stimulates peripheral T cells, increases IFN-γ, IL-2, TNF-α level and inhibits tumor growth in vivo .
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