1 Result for "

D-CopA3

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "D-CopA3" in MCE Product Catalog:

Cat. No.: HY-P10914
CAS No.: 1426227-11-3
Target:  

MDM-2/p53 Autophagy

Research Areas:  

Inflammation/Immunology Cancer

D-CopA3 is the inhibitor for MDM2 and the activator for p53 signaling pathway. D-CopA3 exhibits cytotoxicity in colorectal cancer cells HCT-116, LoVo, and RKO (IC50=15-18 μM), induces JNK/Beclin-1 mediated autophagy. D-CopA3 downregulates the expression of cell cycle inhibitory protein p21Cip1/Waf1, enhances the mucosal barrier function and reduces penetration of inflammatory mediators. D-CopA3 exhibits anti-inflammtory activity in mouse C. difficile toxin A-induced acute enteritis models and DSS (HY-116282)-induced chronic colitis models. D-CopA3 exhibits antitumor efficacy in mouse HCT-116 xenograft models .
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