1 Result for "

DKN01

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "DKN01" in MCE Product Catalog:

Cat. No.: HY-P99906
CAS No.: 2414962-49-3
Synonyms: DKN-01; LY-2812176

Target:  

β-catenin Wnt

Research Areas:  

Cancer

Sirexatamab (DKN-01; LY-2812176) is a humanized IgG4 monoclonal antibody targeting DKK1, with Kd values of 3.3 pM and 20 pM for human and murine (mDKN-01) forms, respectively. Sirexatamab binds to DKK1 to neutralize its activity and reverse the inhibition of the canonical Wnt/β-catenin signaling pathway. Sirexatamab can be used in research related to cancers such as non-small cell lung cancer, endometrial cancer, and ovarian cancer .
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