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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
31 Results for "
ESIPT/ICT
" in MedChemExpress (MCE) Product Catalog:
Products (31)
31 Results for "ESIPT/ICT" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-138561C
Purity: 96.23%
Target:
Research Areas:
EFdA-TP tetralithium is a potent nucleoside reverse transcriptase (RT) inhibitor. EFdA-TP tetralithium inhibits RT-catalyzed DNA synthesis as an effective immediate or delayed chain terminator (ICT or DCT). EFdA-TP tetralithium inhibits HIV-1 RT with multiple mechanisms .
Cat. No.: HY-152293
CAS No.: 1412453-70-3
EVT801 is an orally active and selective inhibitor of VEGFR-3 (IC50=11 nM), which has antitumor effects. EVT801 inhibits not only VEGF-C-induced human endothelial cell proliferation, but also tumor (lymphatic) angiogenesis in tumor mouse models. EVT801 can reduce tumor hypoxia, immunosuppressive cytokines (CCL4, CCL5) and myeloid derived suppressor cells (MDSC) production. EVT801 has synergistic effect with immune checkpoint therapy (ICT), which improves ICT response rate and has better inhibitory effect on cancer mouse models . EVT801 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Cat. No.: HY-W140203
CAS No.: 2963-66-8
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2-(2′-Hydroxyphenyl) benzimidazole is the most extensively studied excited-state intramolecular proton transfer (ESIPT) molecule, exhibiting normal and tautomer emissions. 2-(2′-Hydroxyphenyl) benzimidazole has been applied as a fluorescent probe in various systems .
Cat. No.: HY-138561
CAS No.: 950913-56-1
Research Areas:
EFdA-TP is a potent nucleoside reverse transcriptase (RT) inhibitor. EFdA-TP inhibits RT-catalyzed DNA synthesis as an effective immediate or delayed chain terminator (ICT or DCT). EFdA-TP inhibits HIV-1 RT with multiple mechanisms .
Cat. No.: HY-W024271
CAS No.: 63149-33-7
Synonyms: 9-Formyl-8-hydroxyjulolidine
Target:
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8-Hydroxyjulolidine-9-carboxaldehyde (9-Formyl-8-hydroxyjulolidine) is a highly selective fluorescent probe for hydrogen sulfide (S 2−) and silicate (SiO3 2−). 8-Hydroxyjulolidine-9-carboxaldehyde operates via a mechanism of blocking intramolecular charge transfer (ICT), exhibiting significant fluorescence enhancement in the presence of weak acid ions. 8-Hydroxyjulolidine-9-carboxaldehyde is promising for research of fluorescence imaging of hydrogen sulfide within living cells .
Cat. No.: HY-172930
CAS No.: 2991021-08-8
Research Areas:
PVTX-405 is a selective and oral active IKZF2 molecular glue degrader with a DC50 of 0.7 nM and a Dmax of 91%. PVTX-405 enhances degradation efficiency, significantly reduces off-target degradation, and alleviates hERG inhibition with IC50 of 48 µM. PVTX-405 significantly inhibits the growth of MC38 tumors, with greater synergistic anti-cancer efficacy in combination with immune checkpoint therapies (ICTs) (anti-PD1 or anti-LAG3) in the MC38 mouse tumor xenograft model using Crbn 391V C57BL/6 mice .
Cat. No.: HY-D2479
CAS No.: 2978635-30-0
Cat. No.: HY-138561B
CAS No.: 2883783-00-2
Research Areas:
EFdA-TP tetrasodium is a potent nucleoside reverse transcriptase (RT) inhibitor. EFdA-TP tetrasodium inhibits RT-catalyzed DNA synthesis as an effective immediate or delayed chain terminator (ICT or DCT). EFdA-TP tetrasodium inhibits HIV-1 RT with multiple mechanisms . EFdA-TP (tetrasodium) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Cat. No.: HY-N16571
CAS No.: 65602-55-3
Category:
Target:
Cat. No.: HY-161838
ICT10336 is a hypoxia-responsive prodrug of ATR inhibitor, AZD6738 (HY-19323). ICT10336 is hypoxia-activated and specifically releases AZD6738 only in hypoxic conditions in vitro. This can inhibit ATR activation (T1989 and S428 phosphorylation) and subsequently abrogate HIF1a-mediated adaptation of hypoxic cancers cells, thus selectively inducing cell death in 2D and 3D cancer models. ICT10336 is a metabolic substrate of CYPOR activity.
Cat. No.: HY-129094
CAS No.: 215655-21-3
ICT5040 is a small molecule CXCR4 antagonist (IC50=3.8 μM). ICT5040 inhibits CXCL12-mediated proliferation and migration, and suppresses CXCL12-induced intracellular calcium mobilisation in U87 glioma cells .
Cat. No.: HY-D1470
CAS No.: 210832-86-3
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BADAN is a thiol-reactive, environment-sensitive fluorescent probe used for site-specific labeling of protein cysteine residues to detect protein topology, local polarity, protein-lipid interactions, and conformational changes. The bromoacetyl group of BADAN covalently binds to cysteine thiols, and its fluorescence originates from the intramolecular charge transfer (ICT) excited state. The emission peak position varies with the polarity of the surrounding medium: it blue-shifts to approximately 488 nm in nonpolar environments (such as the hydrophobic core of lipid bilayers) and red-shifts to approximately 496-507 nm in polar environments (such as aqueous phases), independent of enzymes, pH, or membrane potential. Ex = 380-402 nm; Em = 400-600 nm .
Cat. No.: HY-138561A
Research Areas:
EFdA-TP tetraammonium is a potent nucleoside reverse transcriptase (RT) inhibitor. EFdA-TP tetraammonium inhibits RT-catalyzed DNA synthesis as an effective immediate or delayed chain terminator (ICT or DCT). EFdA-TP tetraammonium inhibits HIV-1 RT with multiple mechanisms . EFdA-TP (tetraammonium) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Cat. No.: HY-D2286
Cat. No.: HY-D1417
CAS No.: 2247391-82-6
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P-BP-SFAC is a fluorescence molecule. P-BP-SFAC exhibits an apparent absorption band with a peak at about 377 nm, indicative of a stronger ICT effect .
Cat. No.: HY-D1259
CAS No.: 2414276-32-5
Synonyms: VDP-green (NEP)
Cat. No.: HY-D3067
Target:
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ASSI-Leu is a novel AIE fluorescent probe based on an asymmetric tetraaryl imidazole skeleton, which can be used for ratiometric imaging detection of endogenous leucine aminopeptidase. ASSI-Leu contains an L-leucine-based recognition group that blocks the excited-state intramolecular proton transfer (ESIPT) in its 2-(2'-hydroxyphenyl) benzothiazole (HBT) skeleton, thereby generating an enol-form emission signal at Ex/Em = 365/417 nm. ASSI-Leu undergoes cleavage of the L-leucine group mediated by LAP to form ASSI-OH, which further activates aggregation-induced emission (AIE) and ESIPT, generating a keto-form emission signal at Ex/Em = 365/554 nm and producing a ratiometric fluorescent signal. ASSI-Leu enables real-time tracking of LAP in cancer cells and zebrafish models .\n
Cat. No.: HY-D3117
CAS No.: 2146114-18-1
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Research Areas:
MBCB is a two-photon Fluorescent probe for dual-detection of mitochondrial SO₂ derivatives and viscosity. For SO₂ derivatives detection, the probe utilizes a Michael addition mechanism: nucleophilic addition of SO₂ derivatives to the C=C bond between the carbazole skeleton and 3-methylbenzothiazolium moiety destroys the strong intramolecular charge transfer (ICT) system between these groups, while enhancing the weak ICT system between the benzothiazole group and carbazole framework; this causes the red emission at 600 nm to decrease and the blue emission at 434 nm to increase, creating a ratiometric response based on the I₄₃₄ₙₘ/I₆₀₀ₙₘ intensity ratio. For viscosity detection, in low-viscosity environments, steric hindrance creates a twisted ICT (TICT) system with weak fluorescence, while in high-viscosity environments, intramolecular rotation is blocked, the TICT state is disrupted, and the strong ICT system is recovered, leading to a strong red emission at 567 nm with negligible change to the short-wavelength emission at 415 nm, creating a ratiometric response based on the I₅₆₇ₙₘ/I₄₁₅ₙₘ intensity ratio that has a logarithmic linear relationship with viscosity. The probe has excitation/emission wavelengths of Ex/Em = 351/434, 600 nm for SO₂ derivatives detection and Ex/Em = 351/567 nm for viscosity detection, with two-photon excitation at 740 nm for bioimaging; it also exhibits good mitochondrial targeting ability with a Pearson's colocalization coefficient of 0.93 when paired with Mito-Tracker Green. The probe shows high sensitivity and selectivity for SO₂ derivatives, has low cell cytotoxicity, and can be applied to detect exogenous/endogenous HSO₃⁻ in living cells and in vivo, as well as visualize mitochondrial viscosity changes induced by nystatin[1].
Cat. No.: HY-P88989A
Synonyms: DS-1; DS1; ICT1; MRP-L58
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
