8 Results for "

FANCM

" in MedChemExpress (MCE) Product Catalog:
Products (8)

8 Results for "FANCM" in MCE Product Catalog:

Cat. No.: HY-163573
CAS No.: 3033990-61-0
Target:  

DNA/RNA Synthesis

Research Areas:  

Cancer

FANCM-BTR PPI-IN-1 (Compound 32) is a FANCM/BTR interaction inhibitor that blocks the localization of FANCM to telomeres. FANCM-BTR PPI-IN-1 exhibits anticancer activity against osteosarcoma .
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Cat. No.: HY-124325
CAS No.: 622795-76-0
Purity:  ≥98.0%
Research Areas:  

Cancer

PIP-199 is a selective inhibitor of RMI (RecQ-mediated genome instability protein) core complex/MM2 interaction, with an IC50 of 36 μM. PIP-199 can be used for the research of sensitizing resistant tumors to DNA crosslinking chemotherapeutics .
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Cat. No.: HY-P11224
Target:  

DNA/RNA Synthesis

Research Areas:  

Cancer

RMI-L4 is an efficient cyclic peptide inhibitor that can specifically disrupt the interaction between FANCM and RMI proteins with an IC50 of 54 nM. RMI-L4 engages the FANCM-binding pocket of RMI1/2 with nanomolar affinity (KD = 2.5 nM). RMI-L4 cannot penetrate the cell membrane and can be used to study the FANCM-RMI pathway targeting cancer with alternate lengthening of telomeres (ALT) .
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Cat. No.: HY-RS04741
Research Areas:  

Others

FANCM Human Pre-designed siRNA Set A contains three designed siRNAs for FANCM gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS24756
Research Areas:  

Others

Fancm Rat Pre-designed siRNA Set A contains three designed siRNAs for Fancm gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS18278
Research Areas:  

Others

Fancm Mouse Pre-designed siRNA Set A contains three designed siRNAs for Fancm gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-P11842
Target:  

DNA/RNA Synthesis

Research Areas:  

Cancer

Ac-HFKLYWPPFLGS-NH2 is a RMI1/2 heterodimer inhibitor with an IC50 of 99 nM and antiproliferative activity. Ac-HFKLYWPPFLGS-NH2 binds competitively at the FANCM-RMI interaction interface, mimics native FANCM MM2 domain hydrophobic interactions, and adopts a unique binding pose with additional protein interactions. Ac-HFKLYWPPFLGS-NH2 induces antiproliferative effects in ALT-positive osteosarcoma cells. Ac-HFKLYWPPFLGS-NH2 shows limited stability toward α-chymotrypsin-mediated enzymatic degradation in vitro. Ac-HFKLYWPPFLGS-NH2 lacks inherent cell permeability, requiring conjugation to a cell-penetrating peptide for intracellular delivery. Ac-HFKLYWPPFLGS-NH2 can be used for the research of ALT-positive osteosarcoma .
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Cat. No.: HY-P11841
Target:  

DNA/RNA Synthesis

Research Areas:  

Cancer

tP4-CPP12 is a RMI1/2 heterodimer inhibitor with an IC50 of 110 nM. tP4-CPP12 binds competitively at the FANCM-RMI interaction site and disrupts endogenous FANCM-RMI protein-protein interactions. tP4-CPP12 induces antiproliferative effects in ALT-positive osteosarcoma cells. tP4-CPP12 is applicable for the research of ALT-positive osteosarcoma .
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