Search Result

Isoforms Recommended:	FOXO1

Results for "

FoxO1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (3) Akt (11) AMPK (3) Apoptosis (8) Arrestin (1) Autophagy (5) Bcl-2 Family (1) c-Myc (1) Caspase (2) CD276/B7-H3 (1) DAPK (1) Dopamine Receptor (1) DYRK (1) Endogenous Metabolite (3) Epigenetic Reader Domain (3) ERK (1) FGFR (2) FOXO (13) Glycosidase (1) HDAC (1) Histone Demethylase (1) Isocitrate Dehydrogenase (IDH) (1) JNK (3) Mitochondrial Metabolism (1) Mitophagy (1) MMP (1) NF-κB (1) Nuclear Hormone Receptor 4A/NR4A (1) p38 MAPK (2) PD-1/PD-L1 (1) PDK-1 (1) PERK (1) PI3K (3) PPAR (1) PTEN (1) Reactive Oxygen Species (ROS) (2) Reference Standards (4) Ribosomal S6 Kinase (RSK) (3) ROCK (1) Ser/Thr Protease (2) Sirtuin (1) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (17) Cardiovascular Disease (4) Inflammation/Immunology (5) Metabolic Disease (15) Neurological Disease (10)
Oligonucleotides:	Nucleoside Analogs (2) Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Antibodies

Oligonucleotides

GMP Molecules

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-100596

AS1842856 Maximum Cited Publications 88 Publications Verification	Autophagy	Metabolic Disease
AS1842856, a specific *Foxo1* inhibitor (IC₅₀=30 nM), potently suppresses autophagy ^[1]. AS1842856 reduces *Foxo1* activity and, to a lesser extent, inhibits *Foxo1* protein expression by simply binding to *Foxo1* .

HY-W011527

Xanthosine 3 Publications Verification	Endogenous Metabolite Akt AMPK FOXO	Metabolic Disease
Xanthosine is a nucleoside derived from xanthine and ribose. Xanthosine activates the *AMPK/FoxO1/AKT/GSK3β* signaling cascade. Xanthosine promotes cell proliferation and regulates blood glucose metabolism. Xanthosine increases milk production in cows and goats. Xanthosine is used in mammary stem cell and type 2 diabetes research ^[1] .

HY-153347

JY-2 2 Publications Verification	FOXO	Metabolic Disease
JY-2 is a moderately selective and orally active Forkhead transcription factor forkhead box O1 (FoxO1) inhibitor that inhibits FoxO1 transcriptional activity with an IC₅₀ of 22 μM. JY-2 shows moderate inhibition against FoxO3a and FoxO4. JY-2 shows anti-diabetic activity ^[1].

HY-15145A

SRT 1720 dihydrochloride 55+ Cited Publications	Sirtuin Autophagy	Metabolic Disease
SRT 1720 dihydrochloride is a selective and orally active activator of *SIRT1* with an EC₅₀ of 0.10 μM, and shows less potent activities on SIRT2 and SIRT3 ^[1].

HY-139348

PFI-90 1 Publications Verification	Histone Demethylase Apoptosis	Cancer
PFI-90 is a selective inhibitor of histone demethylase (KDM3B) that inhibits *PAX3-FOXO1* action. PFI-90 induces apoptosis and myogenic differentiation, resulting in the cell death increased. PFI-90 has the potential for the antitumor activity. (patent WO2021101929A1).

HY-N0748

Oxypaeoniflorin 4 Publications Verification	Others	Neurological Disease Inflammation/Immunology
Oxypaeoniflorin, an anti-oxidant, is a monoterpene glycoside compound isolated from Paeoniae species. Oxypaeoniflorin has neuroprotective and anti-inflammatory effects ^[1] .

HY-N0863

Methyl protodioscin NSC-698790; Smilax saponin B	Bcl-2 Family Apoptosis Akt c-Myc ERK p38 MAPK JNK FOXO	Cancer
Methyl protodioscin (NSC-698790; Smilax saponin B) is a multi-target, selective, steroidal diglycoside inhibitor with antitumor activity that induces cell cycle arrest. The mechanism of action of Methyl protodioscin is complex, involving the induction of G2/M cell cycle arrest, regulation of the Bcl-2/Bax apoptotic pathway, inhibition of the *Akt1/c-Myc* axis and MAPK/ERK signaling, while simultaneously downregulating ADAM15 and inducing *FOXO1* to reduce cholesterol synthesis. It also inhibits the JNK/c-Jun pathway, reducing the production of inflammatory factors (IL-6, TNF-α). Methyl protodioscin exhibits significant antitumor (inhibiting proliferation, migration, invasion, and inducing apoptosis), anti-inflammatory, and anti-restenosis activities. Methyl protodioscin can be used in research on lung cancer, prostate cancer, pancreatic cancer, and other tumors, as well as inflammatory diseases such as airway inflammation and enteritis ^[1] .

HY-153617

FOXO1-IN-3 1 Publications Verification	FOXO	Metabolic Disease
FOXO1-IN-3 is a highly-selective and orally active *FOXO1* inhibitor. FOXO1-IN-3 reduces hepatic glucose production in mice. FOXO1-IN-3 improves insulin sensitivity and glucose control in db/db mice without causing weight gain ^[1].

HY-N4102

5,7-Dihydroxy-4-methylcoumarin	Apoptosis JNK FOXO Reactive Oxygen Species (ROS) Caspase	Neurological Disease
5,7-Dihydroxy-4-methylcoumarin is an antioxidant. 5,7-Dihydroxy-4-methylcoumarin protects mouse cochlear hair cells from Cisplatin-induced damage, enhances cell viability and inhibits apoptosis. 5,7-Dihydroxy-4-methylcoumarin downregulates phosphorylated JNK levels, increases the ratio of phosphorylated *FoxO1* to total *FoxO1, scavenges free radicals, reduces ROS* accumulation, maintains mitochondrial membrane potential and alleviates mitochondrial dysfunction. 5,7-Dihydroxy-4-methylcoumarin downregulates the expression of caspase-3 and improves cell viability. 5,7-Dihydroxy-4-methylcoumarin can be used in studies related to ototoxicity ^[1] .

HY-123046

AS1708727 3 Publications Verification	Autophagy	Metabolic Disease Cancer
AS1708727 is an orally active *Foxo1* inhibitor, with EC₅₀ values of 0.33 μM and 0.59 μM for G6Pase and PEPCK, respectively ^[1].

HY-B1152

Piperacetazine 1 Publications Verification	Dopamine Receptor CD276/B7-H3 FOXO	Neurological Disease Cancer
Piperacetazine is an orally active dopamine receptor antagonist and phenothiazine antipsychotic. Piperacetazine can directly bind to the *PAX3::FOXO1* fusion protein and inhibit its transcriptional activity. Piperacetazine also exhibits antitumor activity with an IC₅₀ of 7.627 μM against PANC-1 cells. Piperacetazine can be used for the research of diseases such as schizophrenia and pancreatic cancer and other tumors ^[1] .

HY-P99422

Adebrelimab SHR-1316	PD-1/PD-L1 Apoptosis	Cancer
Adebrelimab (SHR-1316) is a humanized IgG4 monoclonal *PD-L1* (PD-1/PD-L1) antibody. Adebrelimab has promising antitumor activity in solid tumors including extensive-stage small-cell lung cancer (SCLC) ^[1] .

HY-111380

EHT 1610 2 Publications Verification	DYRK	Neurological Disease
EHT 1610 is a potent inhibitor of DYRK, with IC₅₀s of 0.36 nM (DYRK1A), 0.59 nM (DYRK1B), respectively. EHT 1610 exhibits antileukemia effect, regulates cell cycle and induces cell apoptosis ^[1] ^- .

HY-19820A

NSC45586 sodium 1 Publications Verification	Akt Ser/Thr Protease Apoptosis MMP	Cardiovascular Disease Neurological Disease Inflammation/Immunology
NSC45586 sodium is an inhibitor of PHLPP. NSC45586 sodium targets the PP2C phosphatase domains of *PHLPP1* and PHLPP2, blocks the phosphatase activity of PHLPP, increases the expression level of *FOXO1* in the nucleus, and reduces the protein expression of *PHLPP1. NSC45586 sodium activates the AKT* survival signaling pathway, enhances *IGF-1*-induced AKT activation, and inhibits the phosphorylation of AKT/ERK under basal conditions. NSC45586 sodium reduces staurosporine-induced neuronal death, preserves notochord cell morphology and KRT19 expression, inhibits cell apoptosis (apoptosis), improves the viability and proliferation of nucleus pulposus cells, upregulates the expression of ACAN/SOX9, and downregulates the expression of MMP13. NSC45586 sodium binds tightly to bovine serum albumin (bovine serum albumin), and exerts a more significant effect on nucleus pulposus in male individuals. NSC45586 sodium can be used in studies related to global cerebral ischemia and intervertebral disc degeneration ^[1] .

HY-103100

SB-699551 1 Publications Verification	5-HT Receptor Epigenetic Reader Domain Akt Ribosomal S6 Kinase (RSK) FOXO	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
SB-699551 is a selective and brain penetrant 5-HT5A receptor antagonist with a pK_i of 8.2 nM. SB-699551 shows high selectivity over most other 5-HT receptor subtypes, dopamine receptors, and α1B adrenoceptor. SB-699551 disrupts Gαi/o-coupled and PI3K/AKT/mTOR signaling pathways, alters CREB, ATF1, AKT, PRAS40, S6K, and FOXO1 phosphorylation in breast tumor cells. SB-699551 can be used for the research of anxiety, breast cancer, and Alzheimer's disease ^[1] .

HY-N7676

Marein 3 Publications Verification	AMPK HDAC	Cardiovascular Disease Neurological Disease Metabolic Disease
Marein has the neuroprotective effect due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway. Marein improves insulin resistance induced by high glucose in HepG2 cells through CaMKK/AMPK/GLUT1 to promote glucose uptake, through IRS/Akt/GSK-3β to increase glycogen synthesis, and through Akt/FoxO1 to decrease gluconeogenesis. Marein is a HDAC inhibitor with an IC₅₀ of 100 μM. Marein has beneficial antioxidative, antihypertensive, antihyperlipidemic and antidiabetic effects ^[1] .

HY-112056

DIM-C-pPhCO2Me 1 Publications Verification	Nuclear Hormone Receptor 4A/NR4A Apoptosis DAPK Isocitrate Dehydrogenase (IDH) PERK	Cancer
DIM-C-pPhCO2Me is a nuclear receptor 4A1 (NR4A1) antagonist. DIM-C-pPhCO2Me induces Apoptosis. DIM-C-pPhCO2Me decreases *PAX3-FOXO1A, N-Myc, Rassf4, MyoD1, Grem1, and DAPK1* proteins. DIM-C-pPhCO2Me decreases expression of TXNDC5 and *IDH1, induces markers of ER stress (CHOP, ATF4* and p-PERK). DIM-C-pPhCO2Me inhibits renal cell carcinoma, breast cancer. DIM-C-pPhCO2Me can also be used in rhabdomyosarcoma research ^[1] .

HY-137038

N-alpha-Tosyl-Lys chloromethyl ketone hydrochloride TLCK hydrochloride	Caspase Ser/Thr Protease FOXO	Cardiovascular Disease Cancer
N-alpha-Tosyl-Lys chloromethyl ketone hydrochloride (TLCK hydrochloride) is a Serine protease inhibitor with an IC₅₀ of 12.0 μM against Caspase-3, 54.5 μM against Caspase-6, and 19.3 μM against Caspase-7. It inhibits thrombin-induced nuclear translocation of *FOXO1*. N-alpha-Tosyl-Lys chloromethyl ketone hydrochloride can be used in research related to leukemia and cardiovascular diseases ^[1].

HY-N3312

Matairesinol	p38 MAPK JNK NF-κB	Metabolic Disease Inflammation/Immunology Cancer
Matairesinol is an orally active bioactive compound with anti-inflammatory, antioxidant and anticancer activities. Matairesinol inhibits the phosphorylation of MAPK, JNK and NF-κB, downregulates RANKL-induced NFATc1 expression and activity, and suppresses the activation of the *PI3K/AKT/FOXO1* pathway. Matairesinol can be used in research related to sepsis-mediated brain injury, osteoporosis, heart failure, atopic dermatitis and cancer ^[1] .

HY-111299

Psammaplysene A	Apoptosis	Cancer
Psammaplysene A, a brominated tyrosine derivative, can promote the nuclear localization of *FOXO1, leading to cell cycle arrest and apoptosis*, and can be used in cancer research ^[1].

HY-RS05069

FOXO1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
FOXO1 Human Pre-designed siRNA Set A contains three designed siRNAs for FOXO1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

FOXO1 Human Pre-designed siRNA Set A FOXO1 Human Pre-designed siRNA Set A

HY-RS22991

Foxo1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Foxo1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Foxo1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Foxo1 Rat Pre-designed siRNA Set A Foxo1 Rat Pre-designed siRNA Set A

HY-N3542

Carpachromene	Glycosidase	Cancer
Carpachromene is a potent α-glucosidase enzyme inhibitor. Carpachromene ameliorates insulin resistance in HepG2 cells via modulating IR/IRS1/PI3k/Akt/GSK3/FoxO1 pathway ^[1].

HY-W013803

Xanthosine dihydrate	Endogenous Metabolite Akt AMPK FOXO	Metabolic Disease
Xanthosine dihydrate is a nucleoside derived from xanthine and ribose. Xanthosine dihydrate activates the *AMPK/FoxO1/AKT/GSK3β* signaling cascade. Xanthosine dihydrate promotes cell proliferation and regulates blood glucose metabolism. Xanthosine dihydrate increases milk production in cows and goats. Xanthosine dihydrate is used in mammary stem cell and type 2 diabetes research ^[1] .

HY-100596G

AS1842856	Autophagy	Metabolic Disease
AS1842856 (GMP) is AS1842856 (HY-100596) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. AS1842856, a specific *Foxo1* inhibitor (IC₅₀=30 nM), potently suppresses autophagy ^[1]. AS1842856 reduces *Foxo1* activity and, to a lesser extent, inhibits *Foxo1* protein expression by simply binding to *Foxo1* .

HY-16461

Solenopsin (-)-Solenopsin A	Akt Ribosomal S6 Kinase (RSK) PI3K PDK-1 FOXO Mitophagy Reactive Oxygen Species (ROS) Mitochondrial Metabolism	Cardiovascular Disease
Solenopsin ((-)-Solenopsin A) is an ATP-competitive and selective *Akt-1* inhibitor with an IC₅₀ of 5-10 μM, and also acts as an *RSK1* inhibitor. Solenopsin inhibits the activities of *PDK1* in lipid rafts, downregulates PI3K, blocks PI3K-dependent generation of 3-phosphoinositides, and suppresses the phosphorylation of *FOXO1a. Solenopsin induces Mitophagy* and ROS production, reduces mitochondrial oxygen consumption, and exhibits antiproliferative and antiangiogenic activities. Solenopsin can be used in research related to hyperproliferative skin diseases and malignant diseases ^[1] .

HY-100596R

AS1842856 (Standard)	Autophagy Reference Standards	Metabolic Disease
AS1842856 (Standard) is the analytical standard of AS1842856 (HY-100596). This product is intended for research and analytical applications. AS1842856, a specific Foxo1 inhibitor (IC50=30 nM), potently suppresses autophagy ^[1]. AS1842856 reduces Foxo1 activity and, to a lesser extent, inhibits Foxo1 protein expression by simply binding to Foxo1 .

HY-RS16559

Foxo1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Foxo1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Foxo1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Foxo1 Mouse Pre-designed siRNA Set A Foxo1 Mouse Pre-designed siRNA Set A

HY-122959

Kihadanin B	Akt PPAR	Metabolic Disease
Kihadanin B is a citrus limonoid that can be purified from the peels of immature Citrus unshiu. Kihadanin B suppresses adipogenesis through repression of the Akt-FOXO1-PPARγ axis in 3T3-L1 adipocytes ^[1].

HY-124483

W2476	Arrestin	Metabolic Disease
W2476 is a regulator of thioredocin-interacting protein signaling pathway. W2476 promotes competitive binding of forkhead box O1 transcription factor (FOXO1). W2476 can ameliorate β-cell dysfunction and enhance insulin secretion in diabetic mouse model ^[1] .

HY-P4790

Acetyl-Exenatide	PI3K Akt	Metabolic Disease
Acetyl-Exenatideyes is an acetylated derivative of Exenatide. Exenatide has the function similar to insulin, which can be used for research of type 2 diabetes. Exenatide can promote Th17 differentiation, inhibits Tregs differentiation, downregulates PI3K/Akt/FoxO1 phosphorylation ^[1].

HY-E70722

FGFR4 V550E Recombinant Human Active Protein Kinase	FGFR	Cancer
FGFR4 is a transcriptional target of the PAX3-FOXO1 fusion gene. FGFR4 expression is significantly higher in rhabdomyosarcoma. FGFR4 V550E is a mutant of FGFR3 that may be present in rhabdomyosarcoma. FGFR4 V550E Recombinant Human Active Protein Kinase is a recombinant FGFR4 V550E protein that can be used to study FGFR4 V550EK-related functions ^[1].

HY-E70721

FGFR4 N535K Recombinant Human Active Protein Kinase	FGFR	Cancer
FGFR4 is a transcriptional target of the PAX3-FOXO1 fusion gene. FGFR4 expression is significantly higher in rhabdomyosarcoma. FGFR3 K650E is a mutant of FGFR3 that may be present in rhabdomyosarcoma. FGFR4 N535K Recombinant Human Active Protein Kinase is a recombinant FGFR4 N535K protein that can be used to study FGFR4 N535K-related functions ^[1].

HY-W011527R

Xanthosine (Standard)	Reference Standards Endogenous Metabolite	Others
Xanthosine (Standard) is the analytical standard of Xanthosine. This product is intended for research and analytical applications. Xanthosine is a nucleoside derived from xanthine and ribose. Xanthosine activates the *AMPK/FoxO1/AKT/GSK3β* signaling cascade. Xanthosine promotes cell proliferation and regulates blood glucose metabolism. Xanthosine increases milk production in cows and goats. Xanthosine is used in mammary stem cell and type 2 diabetes research ^[1] .

HY-179498

ROCK2-IN-13	FOXO PTEN ROCK Epigenetic Reader Domain PI3K Akt Apoptosis	Cancer
ROCK2-IN-13 is a selective ROCK2 inhibitor. ROCK2-IN-13 reduces nuclear expression by disrupting the interaction of ROCK2 with transcriptional co activators p300> and PGC 1α, repressing oncogenic transcription. ROCK2-IN-13 activates *FOXO1* driven PTEN expression, leading to suppression of the PI3K/Akt pathway, induction of G₂/M cell cycle arrest, and promotion of apoptosis. ROCK2-IN-13 ablates the nuclear transcriptional function of ROCK2 that sustains oncogenic signaling and restores the tumor suppressive *PTEN/FOXO1* axis. ROCK2-IN-13 can be used for prostate cancer reseach ^[1].

HY-149216

Anticancer agent 103	Others	Cancer
Anticancer agent 103 (Compound 2k) is a potent anticancer agent ^[1].

HY-N12385

Hispaglabridin B (R)-Hispaglabridin B	FOXO	Others
Hispaglabridin B is an anti-oxidant agent that can be isolated from Glycyrrhiza glabra. Hispaglabridin B exhibits potent peroxynitrite scavenging activity with an IC₅₀ of 3.2 μM, and shows activity in a low-density lipoprotein (LDL) oxidation system ^[1]. Hispaglabridin B is also a FoxO1 inhibitor . Hispaglabridin B improves muscle wasting by inhibiting catabolism in vivo and in vitro.

HY-N0748R

Oxypaeoniflorin (Standard)	Reference Standards Others	Neurological Disease Inflammation/Immunology
Oxypaeoniflorin (Standard) is the analytical standard of Oxypaeoniflorin. This product is intended for research and analytical applications. Oxypaeoniflorin, an anti-oxidant, is a monoterpene glycoside compound isolated from Paeoniae species. Oxypaeoniflorin has neuroprotective and anti-inflammatory effects ^[1] .

HY-103100R

SB-699551 (Standard)	Reference Standards 5-HT Receptor Epigenetic Reader Domain Akt Ribosomal S6 Kinase (RSK) FOXO	Neurological Disease Cancer
SB-699551 (Standard) is the analytical standard of SB-699551 (HY-103100). This product is intended for research and analytical applications. SB-699551 is a potent and selective 5-HT5A antagonist with a K_i value of 5.1 μM. SB-699551 increases the phosphorylation levels of CREB and ATF1, and decreases the phosphorylation levels of AKT, PRAS40, P70S6K, FOXO1, and S6RP. SB-699551 improves drug-induced cognitive deficits. SB-699551 improves social withdrawal and forgetfulness. SB-699551 inhibits breast cancer.

HY-136700

SB-699551 free base	5-HT Receptor Akt	Neurological Disease Cancer
SB-699551 free base is a selective and brain penetrant 5-HT5A receptor antagonist with a pK_i of 8.2 nM. SB-699551 free base shows high selectivity over most other 5-HT receptor subtypes, dopamine receptors, and α1B adrenoceptor. SB-699551 free base disrupts Gαi/o-coupled and PI3K/AKT/mTOR signaling pathways, alters CREB, ATF1, AKT, PRAS40, S6K, and FOXO1 phosphorylation in breast tumor cells. SB-699551 free base can be used for the research of anxiety, breast cancer, and Alzheimer's disease ^[1] .

AS1842856	Fluorescent Dye
AS1842856 (GMP) is AS1842856 (HY-100596) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. AS1842856, a specific *Foxo1* inhibitor (IC₅₀=30 nM), potently suppresses autophagy ^[1]. AS1842856 reduces *Foxo1* activity and, to a lesser extent, inhibits *Foxo1* protein expression by simply binding to *Foxo1* .

AS1842856	Biochemical Assay Reagents
AS1842856 (GMP) is AS1842856 (HY-100596) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. AS1842856, a specific *Foxo1* inhibitor (IC₅₀=30 nM), potently suppresses autophagy ^[1]. AS1842856 reduces *Foxo1* activity and, to a lesser extent, inhibits *Foxo1* protein expression by simply binding to *Foxo1* .

Cat. No.	Product Name	Target	Research Area

HY-P4790

Acetyl-Exenatide	PI3K Akt	Metabolic Disease
Acetyl-Exenatideyes is an acetylated derivative of Exenatide. Exenatide has the function similar to insulin, which can be used for research of type 2 diabetes. Exenatide can promote Th17 differentiation, inhibits Tregs differentiation, downregulates PI3K/Akt/FoxO1 phosphorylation ^[1].

Cat. No.	Product Name	Target	Research Area	Image

HY-P99422

Adebrelimab SHR-1316	PD-1/PD-L1 Apoptosis	Cancer
Adebrelimab (SHR-1316) is a humanized IgG4 monoclonal *PD-L1* (PD-1/PD-L1) antibody. Adebrelimab has promising antitumor activity in solid tumors including extensive-stage small-cell lung cancer (SCLC) ^[1] .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W011527

Xanthosine 3 Publications Verification	Structural Classification Natural Products Microorganisms Classification of Application Fields Marine natural products Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Akt AMPK FOXO
Xanthosine is a nucleoside derived from xanthine and ribose. Xanthosine activates the *AMPK/FoxO1/AKT/GSK3β* signaling cascade. Xanthosine promotes cell proliferation and regulates blood glucose metabolism. Xanthosine increases milk production in cows and goats. Xanthosine is used in mammary stem cell and type 2 diabetes research ^[1] .

HY-N0748

Oxypaeoniflorin 4 Publications Verification	Other Monoterpenes Monophenols Paeonia lactiflora Pall. Terpenoids Phenols Plants Paeoniaceae Source Classification	Others
Oxypaeoniflorin, an anti-oxidant, is a monoterpene glycoside compound isolated from Paeoniae species. Oxypaeoniflorin has neuroprotective and anti-inflammatory effects ^[1] .

HY-N0863

Methyl protodioscin NSC-698790; Smilax saponin B	Structural Classification other families Classification of Application Fields Plants Disease Research Fields Steroids Source Classification Cancer	Bcl-2 Family Apoptosis Akt c-Myc ERK p38 MAPK JNK FOXO
Methyl protodioscin (NSC-698790; Smilax saponin B) is a multi-target, selective, steroidal diglycoside inhibitor with antitumor activity that induces cell cycle arrest. The mechanism of action of Methyl protodioscin is complex, involving the induction of G2/M cell cycle arrest, regulation of the Bcl-2/Bax apoptotic pathway, inhibition of the *Akt1/c-Myc* axis and MAPK/ERK signaling, while simultaneously downregulating ADAM15 and inducing *FOXO1* to reduce cholesterol synthesis. It also inhibits the JNK/c-Jun pathway, reducing the production of inflammatory factors (IL-6, TNF-α). Methyl protodioscin exhibits significant antitumor (inhibiting proliferation, migration, invasion, and inducing apoptosis), anti-inflammatory, and anti-restenosis activities. Methyl protodioscin can be used in research on lung cancer, prostate cancer, pancreatic cancer, and other tumors, as well as inflammatory diseases such as airway inflammation and enteritis ^[1] .

HY-N4102

5,7-Dihydroxy-4-methylcoumarin	Infection Structural Classification other families Classification of Application Fields Coumarins Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields Source Classification	Apoptosis JNK FOXO Reactive Oxygen Species (ROS) Caspase
5,7-Dihydroxy-4-methylcoumarin is an antioxidant. 5,7-Dihydroxy-4-methylcoumarin protects mouse cochlear hair cells from Cisplatin-induced damage, enhances cell viability and inhibits apoptosis. 5,7-Dihydroxy-4-methylcoumarin downregulates phosphorylated JNK levels, increases the ratio of phosphorylated *FoxO1* to total *FoxO1, scavenges free radicals, reduces ROS* accumulation, maintains mitochondrial membrane potential and alleviates mitochondrial dysfunction. 5,7-Dihydroxy-4-methylcoumarin downregulates the expression of caspase-3 and improves cell viability. 5,7-Dihydroxy-4-methylcoumarin can be used in studies related to ototoxicity ^[1] .

HY-N7676

Marein 3 Publications Verification	Cardiovascular Disease Chalcones Flavonoids other families Neurological Disease Classification of Application Fields Phenols Polyphenols Plants Disease Research Fields Source Classification	AMPK HDAC
Marein has the neuroprotective effect due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway. Marein improves insulin resistance induced by high glucose in HepG2 cells through CaMKK/AMPK/GLUT1 to promote glucose uptake, through IRS/Akt/GSK-3β to increase glycogen synthesis, and through Akt/FoxO1 to decrease gluconeogenesis. Marein is a HDAC inhibitor with an IC₅₀ of 100 μM. Marein has beneficial antioxidative, antihypertensive, antihyperlipidemic and antidiabetic effects ^[1] .

HY-N3312

Matairesinol	Infection Structural Classification other families Classification of Application Fields Anti-aging Lignans Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields Source Classification	p38 MAPK JNK NF-κB
Matairesinol is an orally active bioactive compound with anti-inflammatory, antioxidant and anticancer activities. Matairesinol inhibits the phosphorylation of MAPK, JNK and NF-κB, downregulates RANKL-induced NFATc1 expression and activity, and suppresses the activation of the *PI3K/AKT/FOXO1* pathway. Matairesinol can be used in research related to sepsis-mediated brain injury, osteoporosis, heart failure, atopic dermatitis and cancer ^[1] .

HY-N3542

Carpachromene	Flavonoids Flavones Plants Calophyllaceae Calophyllum symingtonianum M.R.Hend. & Wyatt-Sm. Source Classification	Glycosidase
Carpachromene is a potent α-glucosidase enzyme inhibitor. Carpachromene ameliorates insulin resistance in HepG2 cells via modulating IR/IRS1/PI3k/Akt/GSK3/FoxO1 pathway ^[1].

HY-W013803

Xanthosine dihydrate	Structural Classification Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Akt AMPK FOXO
Xanthosine dihydrate is a nucleoside derived from xanthine and ribose. Xanthosine dihydrate activates the *AMPK/FoxO1/AKT/GSK3β* signaling cascade. Xanthosine dihydrate promotes cell proliferation and regulates blood glucose metabolism. Xanthosine dihydrate increases milk production in cows and goats. Xanthosine dihydrate is used in mammary stem cell and type 2 diabetes research ^[1] .

HY-122959

Kihadanin B	Other Terpenoids Terpenoids Dictamnus dasycarpus Turcz. Rutaceae Plants Source Classification	Akt PPAR
Kihadanin B is a citrus limonoid that can be purified from the peels of immature Citrus unshiu. Kihadanin B suppresses adipogenesis through repression of the Akt-FOXO1-PPARγ axis in 3T3-L1 adipocytes ^[1].

HY-W011527R

Xanthosine (Standard)	Structural Classification Natural Products Microorganisms Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
Xanthosine (Standard) is the analytical standard of Xanthosine. This product is intended for research and analytical applications. Xanthosine is a nucleoside derived from xanthine and ribose. Xanthosine activates the *AMPK/FoxO1/AKT/GSK3β* signaling cascade. Xanthosine promotes cell proliferation and regulates blood glucose metabolism. Xanthosine increases milk production in cows and goats. Xanthosine is used in mammary stem cell and type 2 diabetes research ^[1] .

HY-N12385

Hispaglabridin B (R)-Hispaglabridin B	Structural Classification Natural Products Glycyrrhiza glabra Linn. Leguminosae Plants Source Classification	FOXO
Hispaglabridin B is an anti-oxidant agent that can be isolated from Glycyrrhiza glabra. Hispaglabridin B exhibits potent peroxynitrite scavenging activity with an IC₅₀ of 3.2 μM, and shows activity in a low-density lipoprotein (LDL) oxidation system ^[1]. Hispaglabridin B is also a FoxO1 inhibitor . Hispaglabridin B improves muscle wasting by inhibiting catabolism in vivo and in vitro.

HY-N0748R

Oxypaeoniflorin (Standard)	Structural Classification Other Monoterpenes Monophenols Paeonia lactiflora Pall. Terpenoids Phenols Plants Paeoniaceae Source Classification	Reference Standards Others
Oxypaeoniflorin (Standard) is the analytical standard of Oxypaeoniflorin. This product is intended for research and analytical applications. Oxypaeoniflorin, an anti-oxidant, is a monoterpene glycoside compound isolated from Paeoniae species. Oxypaeoniflorin has neuroprotective and anti-inflammatory effects ^[1] .

Host:	Mouse (2) Rabbit (6)
Reactivity:	Human (8) Rat (1) Mouse (5)
Application:	IHC-P (5) ICC/IF (7) IP (1) IHC-F (3) WB (8) FC (1) ELISA (2)
Isotype:	IgG (6)
Conjugation:	Non-conjugated (8)
Clonality:	Polyclonal (1) Monoclonal (5) Recombinant (2)
Modification:	Unmodified (6)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P85429

	FoxO1 Antibody (YA5121) FoxO1; FKHR; FoxO1A; Forkhead box protein O1; Forkhead box protein O1A; Forkhead in rhabdomyosarcoma	WB, ICC/IF	Human, Mouse
	FoxO1 Antibody (YA5121) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to FoxO1.

HY-P86588

	FOXO1 Antibody (YA6280) FoxO1; FKHR; FoxO1A; Forkhead box protein O1; Forkhead box protein O1A; Forkhead in rhabdomyosarcoma	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse
	FOXO1 Antibody (YA6280) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FOXO1.

HY-P81074

	FOXO1/FOXO1A Antibody FoxO1; FKHR; FoxO1A; Forkhead box protein O1; Forkhead box protein O1A; Forkhead in rhabdomyosarcoma	WB, IHC-P, IHC-F, ICC/IF, ELISA	Human, Mouse, Rat
	FOXO1/FOXO1A Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to FOXO1/FOXO1A.

HY-P85525

	FOXO1(C-term) Antibody (YA5217) FKH 1; FKH1; FKH1; FKHR; FKHR; Forkhead; Drosophila; homolog 1; rhabdomyosarcoma; Forkhead; Drosophila; homolog 1; rhabdomyosarcoma; Forkhead box O1; Forkhead box protein O1; Forkhead box protein O1A; Forkhead in rhabdomyosarcoma; Forkhead, Drosophila, homolog of, in rhabdomyosarcoma; FoxO1; FoxO1; FoxO1_HUMAN; FoxO1A; OTTHUMP00000018301.	WB	Human
	FOXO1(C-term) Antibody (YA5217) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to FOXO1(C-term).

HY-P80676

	FOXO1/FOXO1A Antibody (YA430) FoxO1; FKHR; FoxO1A; Forkhead box protein O1; Forkhead box protein O1A; Forkhead in rhabdomyosarcoma	WB, IHC-F, IHC-P, ICC/IF	Human
	FOXO1/FOXO1A Antibody (YA430) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FOXO1/FOXO1A.

HY-P80676A

	FOXO1/FOXO1A Antibody (YA430)(PBS only) FoxO1; FKHR; FoxO1A; Forkhead box protein O1; Forkhead box protein O1A; Forkhead in rhabdomyosarcoma	WB, IHC-F, IHC-P, ICC/IF	Human
	FOXO1/FOXO1A Antibody (YA430) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FOXO1/FOXO1A.

HY-P810550

	*Phospho-FOXO1A (Thr24)+ FOXO3A (Thr32)+ FOXO4 (Thr28)+ FOXO6 (Thr26) Antibody (YA9819)* FoxO1; FKHR; FoxO1A; Forkhead box protein O1; Forkhead box protein O1A; Forkhead in rhabdomyosarcoma	WB, ICC/IF, FC	Human, Mouse
	Phospho-FOXO1A (Thr24)+ FOXO3A (Thr32)+ FOXO4 (Thr28)+ FOXO6 (Thr26) Antibody (YA9819) is a Rabbit-derived and non-conjugated IgG Recombinant, Monoclonal antibody, targeting to Phospho-FOXO1A (Thr24)+ FOXO3A (Thr32)+ FOXO4 (Thr28)+ FOXO6 (Thr26).

HY-P80132

	FOXO1A Antibody (YA429)	WB, ICC/IF, IHC-P	Human, Mouse
	FOXO1A Antibody (YA429) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FOXO1A.

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Cat. No.	Product Name		Classification

HY-W011527

Xanthosine 3 Publications Verification		Nucleoside Analogs
Xanthosine is a nucleoside derived from xanthine and ribose. Xanthosine activates the *AMPK/FoxO1/AKT/GSK3β* signaling cascade. Xanthosine promotes cell proliferation and regulates blood glucose metabolism. Xanthosine increases milk production in cows and goats. Xanthosine is used in mammary stem cell and type 2 diabetes research ^[1] .

HY-RS05069

FOXO1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
FOXO1 Human Pre-designed siRNA Set A contains three designed siRNAs for FOXO1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS22991

Foxo1 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Foxo1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Foxo1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-W013803

Xanthosine dihydrate		Nucleoside Analogs
Xanthosine dihydrate is a nucleoside derived from xanthine and ribose. Xanthosine dihydrate activates the *AMPK/FoxO1/AKT/GSK3β* signaling cascade. Xanthosine dihydrate promotes cell proliferation and regulates blood glucose metabolism. Xanthosine dihydrate increases milk production in cows and goats. Xanthosine dihydrate is used in mammary stem cell and type 2 diabetes research ^[1] .

HY-RS16559

Foxo1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Foxo1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Foxo1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-100596G

AS1842856	Autophagy	Metabolic Disease
AS1842856 (GMP) is AS1842856 (HY-100596) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. AS1842856, a specific *Foxo1* inhibitor (IC₅₀=30 nM), potently suppresses autophagy ^[1]. AS1842856 reduces *Foxo1* activity and, to a lesser extent, inhibits *Foxo1* protein expression by simply binding to *Foxo1* .

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