2. Immunology/Inflammation Apoptosis
  3. PD-1/PD-L1 Apoptosis
  4. Adebrelimab

Adebrelimab  (Synonyms: SHR-1316)

Cat. No.: HY-P99422 Purity: 97.84%
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Adebrelimab (SHR-1316) is a humanized IgG4 monoclonal PD-L1 (PD-1/PD-L1) antibody. Adebrelimab has promising antitumor activity in solid tumors including extensive-stage small-cell lung cancer (SCLC).

For research use only. We do not sell to patients.

Adebrelimab Chemical Structure

Adebrelimab Chemical Structure

CAS No. : 2247114-85-6

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5 mg USD 780 In-stock
10 mg USD 1250 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Adebrelimab (SHR-1316) is a humanized IgG4 monoclonal PD-L1 (PD-1/PD-L1) antibody. Adebrelimab has promising antitumor activity in solid tumors including extensive-stage small-cell lung cancer (SCLC)[1][2].

In Vitro

Adebrelimab (SHR-1316; 0.06- 1mg/mL; 48 hours) inhibits effects on the cell proliferation, migration, invasion of SK-BR-3 and AU565 cells[1].
Adebrelimab (SHR-1316; 0.1-1mg/mL; 48 hours) downregulateds the expression of PD-L1, p-PI3K, p-AKT and upregulates the expression FOXO1[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Adebrelimab Related Antibodies

Cell Viability Assay[1]

Cell Line: SK-BR-3 and AU565 cells
Concentration: 0.06 mg/mL, 0.13 mg/mL, 0.25 mg/mL, 0.5 mg/mL, 1 mg/mL
Incubation Time: 48 hours
Result: The viability of SK-BR-3 and AU565 cells decreased gradually.

Apoptosis Analysis[1]

Cell Line: SK-BR-3 and AU565 cells
Concentration: 0.1 mg/mL, 1 mg/mL
Incubation Time: 48 hours
Result: Promoted cell apoptosis.

Cell Migration Assay [1]

Cell Line: SK-BR-3 and AU565 cells
Concentration: 0.1 mg/mL, 1 mg/mL
Incubation Time: 48 hours
Result: Decreased the migration rate of SK-BR -3 and AU565 cells.

Western Blot Analysis[1]

Cell Line: SK-BR-3 and AU565 cells
Concentration: 0.1 mg/mL, 1 mg/mL
Incubation Time: 48 hours
Result: Downregulated the expression of PD-L1, p-PI3K, p-AKT and upregulated the expression FOXO1.
In Vivo

Adebrelimab (SHR-1316; 200 μg; three times a week; for 21 days) shows inhibition effects on tumor growth[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Pathogen free (SPF) BALB/c nude female mice (aged 5-6 weeks) injected with SK-BR-3 cells[1]
Dosage: 200 μg
Administration: Three times a week; for 21 days
Result: Significantly inhibited tumor growth.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Adebrelimab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 97.84%

COA (231 KB)

Handling Instructions (2659 KB)
References
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Adebrelimab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Adebrelimab2247114-85-6SHR-1316SHR1316SHR 1316PD-1/PD-L1ApoptosisPD-1/Programmed death-ligand 1PD-L1 antibodyantitumor activityp-PI3Kp-AKTFOXO1Inhibitorinhibitorinhibit

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