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GPN3

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Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-113225
    Guanosine triphosphate

    GTP

    		 Endogenous Metabolite DNA/RNA Synthesis Apoptosis Mitosis Cancer
    Guanosine triphosphate (GTP) is a critical nucleotide and regulator of cellular metabolism. Guanosine triphosphate promotes ribosomal DNA localization, pre-rRNA transcription and ribosome biogenesis by binding to RNA polymerase I and GPN proteins (GPN1/3). Guanosine triphosphate links MYC-dependent ribosome biogenesis to nucleotide sufficiency, acts as a metabolic gatekeeper supporting protein synthesis, DNA/RNA synthesis and cellular signal transduction, while also participating in the physiological activities of pancreatic β-cells and serving as an oxidative substrate for reactive oxygen species. In small cell lung cancer with high MYC expression, Guanosine triphosphate accumulates through the IMPDH-driven synthetic pathway, thereby affecting apoptosis and mitotic processes. Guanosine triphosphate is used in the research of small cell lung cancer, hepatoblastoma and cellular metabolism [3].
    Guanosine triphosphate
  • HY-RS05647
    GPN3 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    GPN3 Human Pre-designed siRNA Set A contains three designed siRNAs for GPN3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    GPN3 Human Pre-designed siRNA Set A
    GPN3 Human Pre-designed siRNA Set A

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