20 Results for "

Glycine Receptor (GlyR)

" in MedChemExpress (MCE) Product Catalog:
Products (20)

20 Results for "Glycine Receptor (GlyR)" in MCE Product Catalog:

77
77 Cited Publications
Cat. No.: HY-16569
CAS No.: 64-86-8
Colchicine, an orally active alkaloid, is a potent tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC50 of 3 nM. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs). Colchicine prevents non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Colchicine has extensive anti-inflammatory, immunosuppressive and strong anti-fibrosis effects and has the potential for gouty arthritis research .
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5
5 Cited Publications
Cat. No.: HY-113329
CAS No.: 543-18-0
Purity:  ≥98.0%
Synonyms: Taurocyamine
Guanidinoethyl sulfonate (Taurocyamine) is an orally available, blood-brain permeable competitive inhibitor of taurine transporters and a competitive antagonist of glycine receptors (GlyR) (IC50=565 μM). Guanidinoethyl sulfonate has both weak agonist and antagonist effects on GABAA receptors. Guanidinoethyl sulfonate inhibits taurine transmembrane transport and competitively binds to the GlyR ligand binding domain, thereby blocking glycine-mediated chloride influx, and may regulate brain pH to exert neuroprotective effects. Guanidinoethyl sulfonate can be used for neuroprotection studies of ischemic brain injury .
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Cat. No.: HY-41700
CAS No.: 338-69-2
Synonyms: (R)-Alanine; Ba 2776; D-α-Alanine
D-Alanine is a weak GlyR (inhibitory glycine receptor) and PMBA agonist, with an EC50 of 9 mM for GlyR .
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Cat. No.: HY-41700S
CAS No.: 177614-69-6
Synonyms: (R)-Alanine-d3; Ba 2776-d3; D-α-Alanine-d3
D-Alanine-d3 is the deuterium labeled D-Alanine. D-Alanine is a weak GlyR (inhibitory glycine receptor) and PMBA agonist, with an EC50 of 9 mM for GlyR.
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Cat. No.: HY-107782
CAS No.: 21416-53-5
Purity:  99.92%
Picrotin is an active compound, also is one of the composition of picrotoxin (an antagonist of GABAA receptors (GABAARs) and glycine receptors (GlyRs)). Picrotin has sensitivity for GlyRs with IC50 values range from 5.2 μM to 106 μM. Picrotin can be used for the research of neurotransmission .
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Cat. No.: HY-16569B
CAS No.: 64-86-8
Colchicine,suitable for plant cell culture, an orally active alkaloid, is a potent tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC50 of 3 nM. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs). Colchicine prevents non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Colchicine,suitable for plant cell culture can be used for plant cell culture .
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Cat. No.: HY-16569R
CAS No.: 64-86-8
Colchicine (Standard) is the analytical standard of Colchicine. This product is intended for research and analytical applications. Colchicine, an orally active alkaloid, is a potent tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC50 of 3 nM. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs). Colchicine prevents non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Colchicine has extensive anti-inflammatory, immunosuppressive and strong anti-fibrosis effects and has the potential for gouty arthritis research .
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Cat. No.: HY-41700S1
CAS No.: 1202063-27-1
Synonyms: (R)-Alanine-d4; Ba 2776-d4; D-α-Alanine-d4
D-Alanine-d4 is the deuterium labeled D-Alanine. D-Alanine is a weak GlyR (inhibitory glycine receptor) and PMBA agonist, with an EC50 of 9 mM for GlyR.
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Cat. No.: HY-113329R
CAS No.: 543-18-0
Synonyms: Taurocyamine (Standard)
Guanidinoethyl sulfonate (Standard) is the analytical standard of Guanidinoethyl sulfonate. This product is intended for research and analytical applications. Guanidinoethyl sulfonate is an orally available, blood-brain permeable competitive inhibitor of taurine transporters and a competitive antagonist of glycine receptors (GlyR) (IC50=565 μM). Guanidinoethyl sulfonate has both weak agonist and antagonist effects on GABAA receptors. Guanidinoethyl sulfonate inhibits taurine transmembrane transport and competitively binds to the GlyR ligand binding domain, thereby blocking glycine-mediated chloride influx, and may regulate brain pH to exert neuroprotective effects. Guanidinoethyl sulfonate can be used for neuroprotection studies of ischemic brain injury .
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Cat. No.: HY-41700S5
CAS No.: 286460-72-8
Synonyms: (R)-Alanine-13C3; Ba 2776-13C3; D-α-Alanine-13C3
D-Alanine- 13C3 ((R)-Alanine- 13C3) is the 13C-labeled D-Alanine (HY-41700). D-Alanine is a weak GlyR (inhibitory glycine receptor) and PMBA agonist, with an EC50 of 9 mM for GlyR .
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Cat. No.: HY-147367
CAS No.: 2079895-60-4
Target:  

Others

Research Areas:  

Neurological Disease

AM-1488 is a potent, orally active glycine receptor (GlyR) potentiator (hGlyRα3 EC50=0.45 μM) .
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Cat. No.: HY-16569S
CAS No.: 1217651-73-4
Colchicine-d6 is the deuterium labeled Colchicine. Colchicine is a tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC50 of 3 nM . Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs) .
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Cat. No.: HY-16569S1
CAS No.: 1217625-62-1
Colchicine-d3 is the deuterium labeled Colchicine. Colchicine is a tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC50 of 3 nM . Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs) .
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Cat. No.: HY-41700S2
CAS No.: 56595-54-1
Synonyms: (R)-Alanine-d1; Ba 2776-d1; D-α-Alanine-d1
D-Alanine-d is the deuterium labeled D-Alanine. D-Alanine is a weak GlyR (inhibitory glycine receptor) and PMBA agonist, with an EC50 of 9 mM for GlyR .
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Cat. No.: HY-41700S3
CAS No.: 2483831-62-3
Synonyms: (R)-Alanine-d7; Ba 2776-d7; D-α-Alanine-d7
D-Alanine-d7 is the deuterium labeled D-Alanine. D-Alanine is a weak GlyR (inhibitory glycine receptor) and PMBA agonist, with an EC50 of 9 mM for GlyR.
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Cat. No.: HY-175470
CAS No.: 1874229-27-2
Research Areas:  

Others

Stearidonoyl glycine is an N-acyl amino acid. Stearidonoyl glycine has a weak potentiating effect on some glycine receptor subtypes, among which the potentiation on GlyRα2 is statistically significant .
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Cat. No.: HY-41700R
CAS No.: 338-69-2
Synonyms: (R)-Alanine (Standard); Ba 2776 (Standard); D-α-Alanine (Standard)
D-Alanine (Standard) is the analytical standard of D-Alanine. This product is intended for research and analytical applications. D-Alanine is a weak GlyR (inhibitory glycine receptor) and PMBA agonist, with an EC50 of 9 mM for GlyR .
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Cat. No.: HY-107782R
CAS No.: 21416-53-5
Picrotin (Standard) is the analytical standard of Picrotin. This product is intended for research and analytical applications. Picrotin is an active compound, also is one of the composition of picrotoxin (an antagonist of GABAA receptors (GABAARs) and glycine receptors (GlyRs)). Picrotin has sensitivity for GlyRs with IC50 values range from 5.2 μM to 106 μM. Picrotin can be used for the research of neurotransmission .
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Cat. No.: HY-124550
CAS No.: 55038-27-2
Synonyms: (+)-Sarcophine
Sarcophine ((+)-Sarcophine) is a potent glycine receptor (GlyR) inhibitor with an IC50 value of 3.9 μM. Sarcophine is a nature product that could be isolated form the Red Sea soft coral Sarcophyton glaucum .
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Cat. No.: HY-W741136
CAS No.: 75520-89-7
(R)-Colchicine is the R-isomer of Colchicine (HY-16569). Colchicine, an orally active alkaloid, is a potent tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC50 of 3 nM. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs). Colchicine prevents non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Colchicine has extensive anti-inflammatory, immunosuppressive and strong anti-fibrosis effects and has the potential for gouty arthritis research .
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