2079895-60-4
2079895-60-4
Chemical Structure
AM-1488
- CAS No.: 2079895-60-4
- Formula:C19H17N3O4S
- Molecular Weight:383.42
IUPAC Name: (3aS,9bS)-2-(benzofuran-5-ylsulfonyl)-5-methyl-1,2,3,3a,5,9b-hexahydro-4H-pyrrolo[3,4-c][1,6]naphthyridin-4-one
InChIKey: QODWZTUPLVMSQR-HZPDHXFCSA-N
SMILES: O=C1[C@@]2([H])[C@@](CN(C2)S(=O)(C3=CC=C(OC=C4)C4=C3)=O)([H])C5=CN=CC=C5N1C
Biological Activity: AM-1488 is a potent, orally active glycine receptor (GlyR) potentiator (hGlyRα3 EC50=0.45 μM)[1][2].
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AM-1488 | AM-1488 is a potent, orally active glycine receptor (GlyR) potentiator (hGlyRα3 EC50=0.45 μM). | |||||||||||||||||||||
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References
- [1]. Xin Huang, et al. Crystal structures of human glycine receptor α3 bound to a novel class of analgesic potentiators. Nat Struct Mol Biol. 2017 Feb;24(2):108-113. [Content Brief]
- [2]. Howard Bregman, et al. The Discovery and Hit-to-Lead Optimization of Tricyclic Sulfonamides as Potent and Efficacious Potentiators of Glycine Receptors. J Med Chem. 2017 Feb 9;60(3):1105-1125. [Content Brief]
Keywords
