D-Alanine-d7
Based on 1 Customer Validation
D-Alanine-d7 is the deuterium labeled D-Alanine. D-Alanine is a weak GlyR (inhibitory glycine receptor) and PMBA agonist, with an EC50 of 9 mM for GlyR.
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- Purity: 99.0%
- CAS No.: 2483831-62-3
- 화학식: C3D7NO2
- 분자량:96.14
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 2483831-62-3
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Unlabeled Cas 338-69-2
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Appearance Solid
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분자량 96.14
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화학식 C3D7NO2
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Color White to off-white
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SMILES
[2H]OC([C@@](N([2H])[2H])([2H])C([2H])([2H])[2H])=O
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Synonyms
(R)-Alanine-d7; Ba 2776-d7; D-α-Alanine-d7
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
H2O : 165 mg/mL (1716.25 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Schmieden V, et al. Pharmacology of the inhibitory glycine receptor: agonist and antagonist actions of amino acids and piperidine carboxylic acid compounds. Mol Pharmacol. 1995 Nov;48(5):919-27. [Content Brief]
[3]. Saitoh T, et al. A novel antagonist, phenylbenzene omega-phosphono-alpha-amino acid, for strychnine-sensitive glycine receptors in the rat spinal cord. Br J Pharmacol. 1994 Sep;113(1):165-70. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 10.4015 mL | 52.0075 mL | 104.0150 mL | 260.0374 mL |
| 5 mM | 2.0803 mL | 10.4015 mL | 20.8030 mL | 52.0075 mL | |
| 10 mM | 1.0401 mL | 5.2007 mL | 10.4015 mL | 26.0037 mL | |
| 15 mM | 0.6934 mL | 3.4672 mL | 6.9343 mL | 17.3358 mL | |
| 20 mM | 0.5201 mL | 2.6004 mL | 5.2007 mL | 13.0019 mL | |
| 25 mM | 0.4161 mL | 2.0803 mL | 4.1606 mL | 10.4015 mL | |
| 30 mM | 0.3467 mL | 1.7336 mL | 3.4672 mL | 8.6679 mL | |
| 40 mM | 0.2600 mL | 1.3002 mL | 2.6004 mL | 6.5009 mL | |
| 50 mM | 0.2080 mL | 1.0401 mL | 2.0803 mL | 5.2007 mL | |
| 60 mM | 0.1734 mL | 0.8668 mL | 1.7336 mL | 4.3340 mL | |
| 80 mM | 0.1300 mL | 0.6501 mL | 1.3002 mL | 3.2505 mL | |
| 100 mM | 0.1040 mL | 0.5201 mL | 1.0401 mL | 2.6004 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
D-Alanine-d7 Related Classifications
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