Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
4 Results for "
GyrB subunit
" in MedChemExpress (MCE) Product Catalog:
Products (4)
4 Results for "GyrB subunit" in MCE Product Catalog:
Cat. No.: HY-P701907
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: DNA gyrase subunit B; EC:5.6.2.2; Type IIA topoisomerase subunit GyrB; GyrB; acrB; cou; himB; hisU; nalC; parA; pcbA; b3699; JW5625
Species:
E.coli
Source:
E. coli
Cat. No.: HY-P701908
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: DNA gyrase subunit B; EC:5.6.2.2; Type IIA topoisomerase subunit GyrB; GyrB; acrB; cou; himB; hisU; nalC; parA; pcbA; b3699; JW5625
Species:
E.coli
Source:
E. coli
Cat. No.: HY-189124
Target:
Research Areas:
Antibacterial agent 372 is a potent antibacterial agent. Antibacterial agent 372 is a DNA gyrase inhibitor that binds to the ATP-binding pocket of the GyrB subunit, downregulates gyrB gene expression, and impedes DNA replication and supercoiling. Antibacterial agent 372 exhibits broad-spectrum antibacterial activity against Gram-positive and Gram-negative bacteria. Antibacterial agent 372 can be used for research on microbial infections .
Cat. No.: HY-189125
Target:
Anticancer agent 360 is a broad-spectrum antibacterial agent. Anticancer agent 360 binds to the ATP pocket of the GyrB subunit of DNA gyrase via an Arg84 salt bridge, interfering with gyrase-dependent DNA supercoiling. Anticancer agent 360 disrupts bacterial biofilms and inhibits the metabolic activity of respiratory chain dehydrogenases. Anticancer agent 360 exhibits activity against Gram-positive bacteria, Gram-negative bacteria, and fungal strains. Anticancer agent 360 exerts selective cytotoxicity against liver cancer cells. Anticancer agent 360 can be used in studies related to bacterial infections and liver cancer .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
