13 Results for "

HAS2

" in MedChemExpress (MCE) Product Catalog:
Products (13)

13 Results for "HAS2" in MCE Product Catalog:

1
1 Cited Publications
Art. -Nr.: HY-14803
CAS. Nr.: 609799-22-6
Reinheit:  99.68%
Synonyms: BMS-214778; VEC-162
Target:  

Melatonin Receptor

Forschungsgebiete:  

Neurological Disease Endocrinology

Tasimelteon (BMS-214778) is an orally active and selective dual melatonin receptor agonist (DMRA). Tasimelteon has 2.1-4.4 times greater affinity for the MT2 receptor than for the MT1 receptor. Tasimelteon is a circadian regulator and has the potential for Non-24-Hour Sleep-Wake Disorder (Non-24) [2].
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1
1 Cited Publications
Art. -Nr.: HY-N0008
CAS. Nr.: 21082-33-7
Orcinol glucoside is an orally active, blood-brain barrier permeable osteoblast proliferation promoter that targets the Nrf2/Keap1, mTOR and p38 signaling pathways. Orcinol glucoside promotes Nrf2 nuclear translocation, upregulates antioxidant enzyme levels, enhances the phosphorylation of mTOR and p70S6K, and inhibits the enzymatic activity of HAS2 as well as the nuclear translocation of GR. Orcinol glucoside also alleviates oxidative stress, inhibits autophagic flux, osteoclastogenesis and TGF-β1-induced M2 polarization, while reducing collagen deposition and effectively promoting the proliferation, differentiation and mineralization of osteoblasts. Orcinol glucoside also exhibits anti-pulmonary fibrosis, anxiolytic and antidepressant activities. Orcinol glucoside can be used in the research of senile and glucocorticoid-induced osteoporosis, idiopathic pulmonary fibrosis (IPF), anxiety and other related diseases [2] .
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Art. -Nr.: HY-131686
CAS. Nr.: 59247-13-1
Ganglioside GT1b (bovine) ammonium is a member of the ganglioside family. Ganglioside GT1b (bovine) ammonium acts as a protective signal against nerve injury-induced spinal synapse elimination. Ganglioside GT1b (bovine) ammonium induces HA synthesis and the phosphorylation of Akt/mTOR in orbital fibroblasts. Ganglioside GT1b (bovine) ammonium enhances porcine oocyte maturation and induce activation of EGFR and ERK1/2 signaling. Ganglioside GT1b (bovine) ammonium is a putative host cell receptor for the Merkel cell polyomavirus. Ganglioside GT1b (bovine) ammonium can be used for the researches of cancer, infection, immunology, endocrinology and neurological disease, such as Thyroid eye disease [2] .
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Art. -Nr.: HY-P2096
CAS. Nr.: 161258-30-6
Hexapeptide-11 is an anti-aging peptide that can protect fibroblasts from premature cell senescence mediated by oxidative stress. Hexapeptide-11 is also a potential stimulator of hyaluronic acid in keratinocytes, and can enhance skin barrier function by upregulating the expression of HAS2 and EGR3, and downregulating the expression of HYAL2. Hexapeptide-11 can also improve skin elasticity [2] .
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Art. -Nr.: HY-RS06007
Forschungsgebiete:  

Others

HAS2 Human Pre-designed siRNA Set A contains three designed siRNAs for HAS2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Art. -Nr.: HY-RS23949
Forschungsgebiete:  

Others

Has2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Has2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Art. -Nr.: HY-RS17492
Forschungsgebiete:  

Others

Has2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Has2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Art. -Nr.: HY-P72222
Reinheit:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: HAS2; Hyaluronan syntHASe 2; EC 2.4.1.212; Hyaluronate syntHASe 2; Hyaluronic acid syntHASe 2; HA syntHASe 2
Species:  
Source:  
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Art. -Nr.: HY-P84704
Synonyms: Hyaluronan syntHASe 2, Hyaluronate syntHASe 2, Hyaluronic acid syntHASe 2, HA syntHASe 2, HAS2

Host:  

Mouse

Application:  

WB, IHC-P, ICC/IF, ELISA

Reactivity:  

Human, Mouse, Rat, Monkey

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Art. -Nr.: HY-P84704A
Synonyms: Hyaluronan syntHASe 2, Hyaluronate syntHASe 2, Hyaluronic acid syntHASe 2, HA syntHASe 2, HAS2

Host:  

Mouse

Application:  

WB, IHC-P, ICC/IF, ELISA

Reactivity:  

Human, Mouse, Rat, Monkey

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Art. -Nr.: HY-14803S
CAS. Nr.: 1962124-51-1
Synonyms: BMS-214778-d5; VEC-162-d5
Tasimelteon-d5 is the deuterium labeled Tasimelteon. Tasimelteon (BMS-214778) is an orally active and selective dual melatonin receptor agonist (DMRA). Tasimelteon has 2.1-4.4 times greater affinity for the MT2 receptor than for the MT1 receptor. Tasimelteon is a circadian regulator and has the potential for Non-24-Hour Sleep-Wake Disorder (Non-24) [2].
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Art. -Nr.: HY-14803R
CAS. Nr.: 609799-22-6
Synonyms: BMS-214778 (Standard); VEC-162 (Standard)
Tasimelteon (Standard) is the analytical standard of Tasimelteon. This product is intended for research and analytical applications. Tasimelteon (BMS-214778) is an orally active and selective dual melatonin receptor agonist (DMRA). Tasimelteon has 2.1-4.4 times greater affinity for the MT2 receptor than for the MT1 receptor. Tasimelteon is a circadian regulator and has the potential for Non-24-Hour Sleep-Wake Disorder (Non-24) [2].
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Art. -Nr.: HY-116973
CAS. Nr.: 159565-60-3
Target:  

HIV

Forschungsgebiete:  

Infection

L-738372 is a non-competitive reversible inhibitor of HIV-1 reverse transcriptase (RT) with an inhibition constant (Ki) of 140 nM against dTTP. When combined with any nucleoside analogs (such as azidothymidine triphosphate, didexoyinosine triphosphate, or didexoycytidine triphosphate), L-738372 exhibits synergistic inhibition of RT activity. L-738372 has 2-3 times more inhibitory potency against the azidothymidine-resistant RT (D67N, K70R, T215Y, K219Q) compared to the wild-type RT. L-738372 holds promise for research in the field of HIV virus treatment .
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