21082-33-7
21082-33-7
Chemical Structure
Orcinol glucoside
- CAS No.: 21082-33-7
- Formula:C13H18O7
- Molecular Weight:286.28
IUPAC Name: (2S,3R,4S,5S,6R)-2-(3-hydroxy-5-methylphenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
InChIKey: YTXIGTCAQNODGD-UJPOAAIJSA-N
SMILES: CC1=CC(O)=CC(O[C@@H]2O[C@@H]([C@@H](O)[C@H](O)[C@H]2O)CO)=C1
Biological Activity: Orcinol glucoside is an orally active, blood-brain barrier permeable osteoblast proliferation promoter that targets the Nrf2/Keap1, mTOR and p38 signaling pathways. Orcinol glucoside promotes Nrf2 nuclear translocation, upregulates antioxidant enzyme levels, enhances the phosphorylation of mTOR and p70S6K, and inhibits the enzymatic activity of HAS2 as well as the nuclear translocation of GR. Orcinol glucoside also alleviates oxidative stress, inhibits autophagic flux, osteoclastogenesis and TGF-β1-induced M2 polarization, while reducing collagen deposition and effectively promoting the proliferation, differentiation and mineralization of osteoblasts. Orcinol glucoside also exhibits anti-pulmonary fibrosis, anxiolytic and antidepressant activities. Orcinol glucoside can be used in the research of senile and glucocorticoid-induced osteoporosis, idiopathic pulmonary fibrosis (IPF), anxiety and other related diseases[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Orcinol glucoside | 98.92% | Orcinol glucoside is an orally active, blood-brain barrier permeable osteoblast proliferation promoter that targets the Nrf2/Keap1, mTOR and p38 signaling pathways. Orcinol glucoside promotes Nrf2 nuclear translocation, upregulates antioxidant enzyme levels, enhances the phosphorylation of mTOR and p70S6K, and inhibits the enzymatic activity of HAS2 as well as the nuclear translocation of GR. Orcinol glucoside also alleviates oxidative stress, inhibits autophagic flux, osteoclastogenesis and TGF-β1-induced M2 polarization, while reducing collagen deposition and effectively promoting the proliferation, differentiation and mineralization of osteoblasts. Orcinol glucoside also exhibits anti-pulmonary fibrosis, anxiolytic and antidepressant activities. Orcinol glucoside can be used in the research of senile and glucocorticoid-induced osteoporosis, idiopathic pulmonary fibrosis (IPF), anxiety and other related diseases. | ||||||||||||||||||||
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Orcinol glucoside (Standard) | ≥98% | Orcinol glucoside (Standard) is the analytical standard of Orcinol glucoside. This product is intended for research and analytical applications. Orcinol glucoside (OG) is an active constituent isolated from Curculigo orchioides, with antidepressant effects. Orcinol glucoside facilitates the shift of MSC fate to osteoblast and prevents adipogenesis via Wnt/β-catenin signaling pathway. | ||||||||||||||||||||
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Arbutin | 99.76% | Arbutin (β-Arbutin) is a competitive inhibitor of tyrosinase, with Kiapp values of 1.42 mM for monophenolase; 0.9 mM for diphenolase. Arbutin is also used as depigmenting agents. Arbutin is a natural polyphenol isolated from the bearberry plant Arctostaphylos uvaursi, possesses with anti-oxidant, anti-inflammatory and anti-tumor properties. | ||||||||||||||||||||
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Tachioside | 99.69% | Tachioside is a phenolic glycoside natural product. Tachioside inhibits antigen-induced mast cell degranulation and TNF-α expression in RBL-2H3 cells; it exhibits melanin inhibitory effects in B16 melanoma cells. Tachioside possesses anti-obesity, antioxidant, and α-glucosidase inhibitory activities. Tachioside has been predicted as a potential anti-breast cancer candidate compound and shows high correlation coefficients with antioxidant indicators such as ABTS and FRAP. Tachioside can be used in research on allergies and pigmentation-related diseases. | ||||||||||||||||||||
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Taxicatin | Taxicatin can be found in the leaves of taxus baccata. Taxicatin can be studied for its fermentative action. | |||||||||||||||||||||
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Homoarbutin | Homoarbutin is a phenolic glycoside isolated from the whole plants of Pyrola japonica. | |||||||||||||||||||||
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α-Arbutin (Standard) | 99.65% | α-Arbutin (Standard) is the analytical standard of α-Arbutin. This product is intended for research and analytical applications. α-Arbutin (4-Hydroxyphenyl α-D-glucopyranoside) is emerging as popular and effective skin whiteners, acting as tyrosinase inhibitor. | ||||||||||||||||||||
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Phlorin | 98% | Phlorin (Phloroglucinol β-D-glucoside) is a phloroglucinol (PG) glucoside. | ||||||||||||||||||||
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Koaburaside | Koaburaside is a cytoprotective and anti-inflammatory natural compound. Koaburaside shows antioxidant activity with an IC50 of 9.0 μM for DPPH-free radical scavenging assay. Koaburaside inhibits histamine release and expressions of IL-6 and TNF-α in human mast cells. Koaburaside also effectively inhibits influenza A neuraminidase. | |||||||||||||||||||||
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Isotachioside | 99.91% | Isotachioside is a naturally occurring phenolic aromatic glycoside and an isomer of Tachioside (HY-N1186), possessing various activities such as antioxidant, anti-inflammatory, and antifungal effects. Isotachioside scavenges free radicals and inhibits the release of pro-inflammatory factors. Isotachioside inhibits tumor cell proliferation, delays cellular senescence, and inhibits α-glucosidase. Isotachioside can be used in research related to oxidative stress, metabolism, cancer, and other diseases. | ||||||||||||||||||||
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Isohomoarbutin | Isohomoarbutin is a Phenols product that can be isolated from the whole herbs of Pyrola rotundifolia.. | |||||||||||||||||||||
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11-Dehydroxygrevilloside B | 11-Dehydroxygrevilloside B is a glucopyranoside. | |||||||||||||||||||||
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References
- [1]. Gong W, et al. Orcinol Glucoside Improves Senile Osteoporosis through Attenuating Oxidative Stress and Autophagy of Osteoclast via Activating Nrf2/Keap1 and mTOR Signaling Pathway. Oxid Med Cell Longev. 2022;2022:5410377. Published 2022 May 9. [Content Brief]
- [2]. He XY, et al. Orcinol glucoside targeted p38 as an agonist to promote osteogenesis and protect glucocorticoid-induced osteoporosis. Phytomedicine. 2023;119:154953. [Content Brief]
- [3]. Li C, et al. Orcinol glucoside ameliorates pulmonary fibrosis by suppressing hyaluronic acid synthesis and macrophage M2 polarization via targeting hyaluronic acid synthase 2. Int J Mol Med. 2026;57(4):93. [Content Brief]
- [4]. Wang X, et al. Anxiolytic effects of orcinol glucoside and orcinol monohydrate in mice. Pharm Biol. 2015;53(6):876-881. [Content Brief]
