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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
4 Results for "
HCV genotypes 2b
" in MedChemExpress (MCE) Product Catalog:
Products (4)
4 Results for "HCV genotypes 2b" in MCE Product Catalog:
20
20 Cited Publications
Synonyms: ITMN-191; R7227; RO5190591; RG7227
Target:
Research Areas:
Danoprevir (ITMN-191) is an orally active NS3/4A protease inhibitor for hepatitis C virus (HCV) with an IC50 of 0.29 nM and is selective for NS3/4A over a panel of 53 proteases (IC50 higher than 10 μM). Danoprevir (ITMN-191) inhibits HCV genotypes 1a, 1b, 4, 5, and 6 (IC50s=0.2-0.4 nM) as well as 2b and 3a (IC50s=1.6, 3.5 nM) . Danoprevir is also a SARS-CoV 3CL pro inhibitor with an IC50 of 0.05 μM .
Cat. No.: HY-131905S
CAS No.: 1606150-08-6
Cat. No.: HY-10238R
CAS No.: 850876-88-9
Synonyms: ITMN-191 (Standard); R7227 (Standard); RO5190591 (Standard); RG7227 (Standard)
Target:
Research Areas:
Danoprevir (Standard) is the analytical standard of Danoprevir (HY-10238). This product is intended for research and analytical applications. Danoprevir (ITMN-191) is an orally active NS3/4A protease inhibitor for hepatitis C virus (HCV) with an IC50 of 0.29 nM and is selective for NS3/4A over a panel of 53 proteases (IC50 higher than 10 μM). Danoprevir (ITMN-191) inhibits HCV genotypes 1a, 1b, 4, 5, and 6 (IC50s=0.2-0.4 nM) as well as 2b and 3a (IC50s=1.6, 3.5 nM) . Danoprevir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 0.05 μM .
Cat. No.: HY-184880
CAS No.: 1410114-25-8
Target:
Research Areas:
BMS-986144 non-deuterated is the non-tritium form of BMS-986144 (HY-131905S). BMS-986144 non-deuterated is an orally active inhibitor of HCV NS3/4A protease. BMS-986144 non-deuterated binds to the active site of HCV NS3/4A protease and induces conformational changes in the protease. BMS-986144 non-deuterated reduces time-dependent CYP3A4 inhibition, exhibits hepatic microsomal metabolic stability, and undergoes oxidation of the macrocyclic linker chain. BMS-986144 non-deuterated can be used in studies related to hepatitis C virus infection .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
