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HPAF

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Phosphatase (1) Platelet-activating Factor Receptor (PAFR) (3) ROR (1) SHP1 (1) SHP2 (1)
By Research Areas:	Cancer (3) Cardiovascular Disease (2)

Inhibitors & Agonists

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-128694

Foropafant SR27417	Platelet-activating Factor Receptor (PAFR)	Cardiovascular Disease
Foropafant (SR27417) highly potent, competitive, selective and orally active antagonist of platelet-activating factor (PAF) receptor, with a K_i value of 57 pM for [ ³H]PAF binding, at least 5-fold lower than that of unlabeled PAF itself. Foropafant potently inhibits PAF-induced aggregation of rabbit and human platelets .

HY-19121A

TCV-309 chloride	Platelet-activating Factor Receptor (PAFR)	Cancer
TCV-309 chloride is a potent and specific platelet activating factor (PAF) antagonist. TCV-309 chloride specifically inhibits PAF-induced aggregation of rabbit and human platelets, and [3H]PAF binding to rabbit platelet microsomes with IC₅₀ values of 33 nM, 58 nM and 27 nM, respectively. TCV-309 chloride has beneficial effects in anaphylactic shock .

HY-120159

GS-493	SHP2 SHP1 Phosphatase	Cancer
GS-493 is a selective protein tyrosine phosphatase SHP2 (PTPN11) inhibitor with an IC₅₀ of 71 nM. GS-493 is 29- and 45-fold more active toward SHP2 than related SHP1 and PTP1B. GS-493 blocks cellular motility and growth of cancer cells. Antitumor activity .

HY-155542

RORγ antagonist 1	ROR	Cancer
RORγ antagonist 1 (compound 22), a potent betulinic acid derivative, is an antagonist of RORγ (K_D=0.18 μM). RORγ antagonist 1 exhibits anti-proliferative activity in HPAF-II pancreatic cancer xenograft model. RORγ antagonist 1 inhibits RAS/MAPK and AKT/mTORC1 pathway, and induces caspase-dependent apoptosis in pancreatic cancer cells .

HY-124887

L 651142	Platelet-activating Factor Receptor (PAFR)	Cardiovascular Disease
L 651142 is a weak platelet activating factor (PAF) receptor antagonist. L 651142 inhibits the binding of [ ³H]PAF to rabbit platelet, human platelet or human lung membranes with K_is of 0.839 μM, 1.82 μM, 3.64 μM, respectively .

Host:	Rabbit (2)
Reactivity:	Human (2) mouse (1) rat (1) Rat (1) Mouse (1)
Application:	WB (1) WB ICC/IF (1)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (1) Recombinant (1)
Modification:	Unmodified (1)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P82760

	PAF1 Antibody (YA2505) HPAF1; PAF1; PD2	WB	Human, Mouse, Rat
	PAF1 Antibody (YA2505) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PAF1.

HY-P810477

	PAF1 Antibody (YA9775) PAF1 Homolog, Paf1/RNA Polymerase II Complex Component, PD2, F23149_1, RNA Polymerase II-Associated Factor 1 Homolog, Pancreatic Differentiation Protein 2, FLJ11123, Paf1, RNA Polymerase II Associated Factor, Homolog (S. Cerevisiae), Paf1, RNA Polymerase II Associated Factor, Homolog, HPAF1	WB ICC/IF	Human, mouse, rat
	PAF1 Antibody (YA9775) is a Rabbit-derived and non-conjugated IgG Monoclonal, Recombinant antibody, targeting to PAF1.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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