1 Result for "

ID11916

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "ID11916" in MCE Product Catalog:

Cat. No.: HY-173640
CAS No.: 2785317-21-5
Research Areas:  

Cancer

ID11916 is an orally active androgen receptor (AR) antagonist and a phosphodiesterase 5 (PDE5) inhibitor. ID11916 blocks androgen binding to AR, nuclear translocation, and androgen-dependent transcriptional activity of AR, while increasing intracellular cGMP levels and activating PKG via inhibition. ID11916 shows potent anti-cancer effect in prostate cancer cell lines VCaP and 22Rv1 and in AR-positive breast cancer cell lines SK-BR-3 .
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