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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
67 Results for "
IL-1 antagonist
" in MedChemExpress (MCE) Product Catalog:
Products (67)
67 Results for "IL-1 antagonist" in MCE Product Catalog:
56
56 Publications Verification
Synonyms: Kineret; Anakinra
Target:
Research Areas:
49
49 Cited Publications
Synonyms: 6-Hydroxydopamine hydrobromide; 6-OHDA hydrobromide
Target:
Dopamine Receptor Autophagy Mitophagy COX PGE synthase Interleukin Related p38 MAPK Apoptosis Caspase
Research Areas:
Oxidopamine (6-OHDA) hydrobromide is an antagonist of the neurotransmitter dopamine. Oxidopamine hydrobromide is a widely used neurotoxin and selectively destroys dopaminergic neurons. Oxidopamine hydrobromide promotes COX-2 activation, leading to PGE2 synthesis and pro-inflammatory cytokine IL-1β secretion. Oxidopamine hydrobromide can be used for the research of Parkinson’s disease (PD), attention-deficit hyperactivity disorder (ADHD), and Lesch-Nyhan syndrome .
49
49 Cited Publications
Cat. No.: HY-B1081
CAS No.: 28094-15-7
Synonyms: 6-Hydroxydopamine Hydrochloride
Target:
Dopamine Receptor Autophagy Mitophagy COX PGE synthase Interleukin Related p38 MAPK Apoptosis Caspase
Research Areas:
Oxidopamine (6-OHDA) hydrochloride is an antagonist of the neurotransmitter dopamine. Oxidopamine hydrochloride is a widely used neurotoxin and selectively destroys dopaminergic neurons. Oxidopamine hydrochloride promotes COX-2 activation, leading to PGE2 synthesis and pro-inflammatory cytokine IL-1β secretion. Oxidopamine hydrochloride can be used for the research of Parkinson’s disease (PD), attention-deficit hyperactivity disorder (ADHD), and Lesch-Nyhan syndrome .
10
10 Cited Publications
Synonyms: Norcoclaurine; Demethyl-Coclaurine
10
10 Cited Publications
Cat. No.: HY-19975
CAS No.: 946387-07-1
Target:
Research Areas:
RN-1734 is selective antagonist of the TRPV4 channel, completely antagonizes 4αPDD-mediated activation of TRPV4 with comparable, low micromolar IC50s for all three species (hTRPV4: 2.3 μM, mTRPV4: 5.9 μM, rTRPV4: 3.2 μM) . RN-1734 clearly decreases the production of tumor necrosis factor α (TNF-α) and interleukin 1β (IL-1β) without altering the number of olig2-positive cells .
9
9 Cited Publications
Cat. No.: HY-P72566
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL1RN; IL-1ra; Interleukin 1 Receptor antagonist; Intracellular Interleukin-1 Receptor antagonist (IcIL-1ra); ICIL-1RA; Intracellular Interleukin-1 Receptor antagonist; IL-1RN; Intracellular IL-1 Receptor antagonist Type II; IL1RA; Type II Interleukin-1 R
Species:
Mouse
Source:
E. coli
6
6 Cited Publications
Cat. No.: HY-P1110
CAS No.: 185413-30-3
Target:
Research Areas:
5
5 Cited Publications
Cat. No.: HY-P7029
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL1RN; IL-1ra; Interleukin 1 Receptor antagonist; Intracellular Interleukin-1 Receptor antagonist (IcIL-1ra); ICIL-1RA; Intracellular Interleukin-1 Receptor antagonist; IL-1RN; Intracellular IL-1 Receptor antagonist Type II; IL1RA; Type II Interleukin-1 R
Species:
Human
Source:
E. coli
3
3 Cited Publications
Target:
Research Areas:
JNJ-55308942 is a high-affinity, selective, brain-penetrant P2X7 functional antagonist (hP2X7: IC50=10 nM, Ki=7.1 nM; rP2X7: IC50=15 nM, Ki=2.9 nM). JNJ-55308942 is orally bioavailable, binds to brain P2X7 and blocks IL-1β release from adult rodent brain .
3
3 Cited Publications
Cat. No.: HY-B0419
CAS No.: 89226-50-6
Target:
Research Areas:
Manidipine is an orally active calcium channel antagonist. Manidipine regulates the expression of cytokines (IL-1β, IL-6). Manidipine has a hypotensive effect. Manidipine can be used in the study of cardiovascular diseases (such as hypertension, myocardial ischemia-reperfusion injury, ventricular hypertrophy), kidney diseases (such as glomerular diseases), and epilepsy .
2
Target:
Research Areas:
2
2 Cited Publications
Target:
Research Areas:
CU-115 is a potent TLR8 antagonist (IC50=1.04 µM), and shows selective for TLR8 over TLR7 (IC50=>50 µM). CU-115 decreases TNF-α and IL-1β production activated by R-848 in THP-1 cells .
2
2 Cited Publications
Target:
Research Areas:
A 839977 is a P2X7 selective antagonist; it blocks BzATP-evoked calcium influx at recombinant human, rat and mouse P2X7 receptors (IC50 values are 20 nM, 42 nM and 150 nM respectively) and reduces inflammatory and neuropathic pain in animal models; the antihyperalgesic effects of P2X7 receptor blockade are mediated by blocking the release of IL-1beta .
2
2 Cited Publications
Cat. No.: HY-P7029A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL1RN; IL-1ra; Interleukin 1 Receptor antagonist; Intracellular Interleukin-1 Receptor antagonist (IcIL-1ra); ICIL-1RA; Intracellular Interleukin-1 Receptor antagonist; IL-1RN; Intracellular IL-1 Receptor antagonist Type II; IL1RA; Type II Interleukin-1 R
Species:
Human
Source:
HEK293
2
2 Cited Publications
Cat. No.: HY-P72570
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL1F10; MGC119832; Interleukin 1 FamILy Member 10; MGC119833; IL-1HY2; MGC11983; IL1-Theta; IL1HY2; IL-1F10; Interleukin-1 Receptor antagonist-Like FIL1 Theta; FKSG75; Interleukin 1 FamILy, Member 10 (Theta); IL-38; Interleukin 1 FamILy Member 10 (Theta)
Species:
Human
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-N5084
CAS No.: 205370-59-8
1
Target:
Cholecystokinin Receptor Ephrin Receptor Interleukin Related VEGFR HIF/HIF Prolyl-Hydroxylase Akt
Research Areas:
Nastorazepide (Z-360) is an orally active 1,5-benzodiazepine derivative and gastrin/CCK-2 receptor antagonist. Nastorazepide inhibits the specific binding of [ 3H]CCK-8 to the human CCK-2 receptor with a Ki value of 0.47 nM. Nastorazepide inhibits IL-1β, ephrin B1, VEGF, and HIF-1alpha, reduces Akt and NR2B phosphorylation. Nastorazepide has antitumor activity against pancreatic cancer. Nastorazepide inhibits colorectal cancer liver metastasis and relieves pain .
1
1 Cited Publications
Cat. No.: HY-P71601Y
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL1F10; MGC119832; Interleukin 1 FamILy Member 10; MGC119833; IL-1HY2; MGC11983; IL1-Theta; IL1HY2; IL-1F10; Interleukin-1 Receptor antagonist-Like FIL1 Theta; FKSG75; Interleukin 1 FamILy, Member 10 (Theta); IL-38; Interleukin 1 FamILy Member 10 (Theta)
Species:
Mouse
Source:
E. coli
Cat. No.: HY-P99111
CAS No.: 476181-74-5
Synonyms: CNTO-148
Research Areas:
Cat. No.: HY-W011978
CAS No.: 1218-34-4
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
