1 Result for "

IMP701

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "IMP701" in MCE Product Catalog:

Referencia número: HY-P99027
No. CAS: 2137049-37-5
Synonyms: LAG525; IMP701; Hu5A8

Target:  

LAG-3

Áreas de investigación:  

Cancer

Ieramilimab (LAG525; IMP701) is a humanized IgG4 monoclonal antibody that binds to LAG-3, resulting in inhibition of LAG-3 interaction with MHC-II molecules. Ieramilimab restores T-cell and NK-cell-mediated antileukemic immunity by reducing exhaustion and augmenting cytokine output and cytotoxicity. Ieramilimab increases the infiltration of cytotoxic T lymphocytes and reduces baseline densities of regulatory T cells (Tregs) and ADAM10-expressing tumor cells. Ieramilimab can be used for the study of various malignancies including melanoma, RCC, and advanced solid tumors .
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