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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2 Results for "
KN026
" in MedChemExpress (MCE) Product Catalog:
Products (2)
2 Results for "KN026" in MCE Product Catalog:
1
Cat. No.: HY-185815
Research Areas:
JSKN003 is a bispecific antibody-drug conjugate (BsADC) targeting HER2. JSKN003, constructed based on the bispecific antibody KN026 (HY-P99437), uses a proprietary Fc glycosylation site-specific conjugation technology to precisely link with DXd (HY-13631D), a topoisomerase I inhibitor. JSKN003 binds to FcγRIIIa on immune effector cells (Kd = 150 nM), thereby inducing antibody-dependent cell-mediated cytotoxicity. JSKN003 induces tumor cell apoptosis via DNA damage triggered by topoisomerase I inhibition. JSKN003 exhibits a bystander killing effect and can be used for the research of HER2-positive tumors .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
