1 Result for "

LS104

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "LS104" in MCE Product Catalog:

Cat. No.: HY-118084
CAS No.: 368836-72-0
Synonyms: Tyrene CR-4
LS-104 (Tyrene CR-4) is a non-ATP-competitive kinase inhibitor against JAK2, Bcr-Abl and FLT3. LS-104 potently induces apoptosis in JAK2V617F-positive cells and inhibits JAK2 autophosphorylation and downstream signal transduction. LS-104 also inhibits proliferation and induces potent cytotoxic effects in FLT3 expressing leukemic cells. LS-104 is a hydroxystyryl-acrylonitrile compound, which is promising for research of myeloproliferative disorders and refractory/relapsed hematologic malignancies .
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