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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
16 Results for "
Leucine-rich repeat kinase 2
" in MedChemExpress (MCE) Product Catalog:
Products (16)
16 Results for "Leucine-rich repeat kinase 2" in MCE Product Catalog:
3
Target:
Research Areas:
PFE-360 (PF-06685360) is a potent, selective, brain penetrated and orally active leucine-rich repeat kinase 2 (LRRK2) inhibitor with a mean IC50 of 2.3 nM in vivo .
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GNE-9605 is a potent, orally active, selective Leucine-rich repeat kinase 2 (LRRK2) inhibitor with an IC50 value of 18.7 nM. GNE-9605 inhibits LRRK2 Ser1292 autophosphorylation. GNE-9605 can be used in research of Parkinson's disease (PD) .
Cat. No.: HY-134562
CAS No.: 1622291-81-9
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PF-06371900 is a potent and highly selective leucine rich repeat kinase 2 (LRRK2) inhibitor .
Cat. No.: HY-148353
CAS No.: 1527474-15-2
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PF-06455943 is a leucine rich repeat kinase 2 (LRRK2) inhibitor with IC50 value of 3 nM. PF-06455943 also is a PET radioligand. PF-06455943 can be used for the research of ADME/neuro PK characterization and Parkinson disease (PD) .
Cat. No.: HY-144074
CAS No.: 2641054-59-1
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LRRK2-IN-4 is a potent, selective, CNS-penetran and orally active leucine-rich repeat kinase 2 (LRRK2) inhobitor with an IC50 of 2.6 nM. LRRK2-IN-4 has the potential for the research of Parkinson’s disease .
Cat. No.: HY-165543
CAS No.: 1482305-44-1
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SRI-29132 is a potent leucine-rich repeat kinase 2 (LRRK2) inhibitor. SRI-29132 is promising for research of Parkinson’s disease .
Cat. No.: HY-151441
CAS No.: 2892451-45-3
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LRRK2-IN-5 (compound 25) is a potent, orally active, selective leucine rich repeat protein kinase 2 gene (LRRK2) inhibitor with IC50 values of 1.2 and 16 μM for GS LRRK2 and WT LRRK2, respectively. LRRK2-IN-5 inhibits LRRK2 Ser1292 and Ser925 autophosphorylation. LRRK2-IN-5 can cross the blood-brain barrier .
Cat. No.: HY-151444
CAS No.: 2892451-17-9
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LRRK2-IN-6 (compound 22) is a potent, orally active, selective leucine rich repeat protein kinase 2 gene (LRRK2) inhibitor with IC50 values of 4.6 and 49 μM for GS LRRK2 and WT LRRK2, respectively. LRRK2-IN-6 inhibits LRRK2 Ser1292 and Ser925 autophosphorylation. LRRK2-IN-6 can cross the blood-brain barrier .
Cat. No.: HY-171801
CAS No.: 3031514-69-6
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PROTAC LRRK2 Degrader-1 (compound 18) is a leucine-rich repeat kinase 2 (LRRK2) PROTAC degrader with an IC 50 value less than 10 nM. PROTAC LRRK2 Degrader-1 can be used in the research of Parkinson's disease .
Cat. No.: HY-P703644
Purity: ≥ 70%, as determined by reducing SDS-PAGE.
Synonyms: LRRK2; DKFZp434H2111; Prev. PARK8; Non-Specific Serine/Threonine Protein kinase; Leucine-rich repeat Serine/Threonine-Protein kinase 2; Parkinson Disease (Autosomal Dominant) 8; Dardarin; Augmented In Rheumatoid Arthritis 17; ROCO2; AURA17; RIPK7; Leucine
Species:
Human
Source:
Sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
