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Results for "

Local anesthetic

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (4) Androgen Receptor (1) Apoptosis (2) Bacterial (6) Biochemical Assay Reagents (1) Calcium Channel (6) Cholinesterase (ChE) (2) Cytochrome P450 (1) Dopamine Receptor (1) Drug Derivative (1) Drug Metabolite (1) Endogenous Metabolite (4) Environmental Pollutants (3) Glycosidase (2) Histamine Receptor (2) iGluR (5) Isotope-Labeled Compounds (2) Monoamine Transporter (3) nAChR (3) NF-κB (4) NOD-like Receptor (NLR) (4) Opioid Receptor (2) Parasite (2) Phytohormone (1) Potassium Channel (4) Reference Standards (13) Sodium Channel (32) TRP Channel (3)
By Research Areas:	Cancer (5) Cardiovascular Disease (6) Endocrinology (1) Infection (4) Inflammation/Immunology (3) Metabolic Disease (4) Neurological Disease (51)

By Targets:

Adrenergic Receptor (4)

Androgen Receptor (1)

Apoptosis (2)

Bacterial (6)

Biochemical Assay Reagents (1)

Calcium Channel (6)

Cholinesterase (ChE) (2)

Cytochrome P450 (1)

Dopamine Receptor (1)

Drug Derivative (1)

Drug Metabolite (1)

Endogenous Metabolite (4)

Environmental Pollutants (3)

Glycosidase (2)

Histamine Receptor (2)

iGluR (5)

Isotope-Labeled Compounds (2)

Monoamine Transporter (3)

nAChR (3)

NF-κB (4)

NOD-like Receptor (NLR) (4)

Opioid Receptor (2)

Parasite (2)

Phytohormone (1)

Potassium Channel (4)

Reference Standards (13)

Sodium Channel (32)

TRP Channel (3)

By Research Areas:

Cancer (5)

Cardiovascular Disease (6)

Endocrinology (1)

Infection (4)

Inflammation/Immunology (3)

Metabolic Disease (4)

Neurological Disease (51)

Inhibitors & Agonists

Screening Libraries

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0405

Bupivacaine 4 Publications Verification	iGluR Sodium Channel Calcium Channel Potassium Channel	Neurological Disease Cancer
Bupivacaine is a NMDA receptor inhibitor. Bupivacaine can block sodium, L-calcium, and potassium channels.Bupivacaine potently blocks SCN5A channels with the IC₅₀ of 69.5 μM. Bupivacaine can be used for the research of chronic pain .

HY-B0985

Phenazopyridine hydrochloride 2 Publications Verification	TRP Channel	Neurological Disease
Phenazopyridine hydrochlorideis a competitive SARM1 inhibitor, with IC₅₀ 145 μM. Phenazopyridine hydrochlorideis a TRPM8 antagonist. Phenazopyridine hydrochloride has a local anesthetic/analgesic effect. Phenazopyridine hydrochlorideis used to relieve painful symptoms of conditions such as cystitis and urethritis. Phenazopyridine hydrochloridecan promote neuronal differentiation and can also be used in the study of traumatic brain injury, peripheral neuropathy and neurodegenerative diseases .

HY-B0986

Hexylresorcinol 4-Hexylresorcinol	Environmental Pollutants Apoptosis Parasite Endogenous Metabolite Bacterial Glycosidase	Infection Metabolic Disease Cancer
Hexylresorcinol (4-Hexylresorcinol) is a natural compound found in plants with antimicrobial, anthelmintic, antiseptic and antitumor activities. Hexylresorcinol can induce apoptosis in squamous carcinoma cells. Hexylresorcinol is a reversible and noncompetitive inhibitor of α-glucosidase. Hexylresorcinol has protective effects against oxidative DNA damage .

HY-Y0258

Benzocaine 1 Publications Verification	Environmental Pollutants Sodium Channel Bacterial	Infection Neurological Disease
Benzocaine is an orally active local anesthetic. Benzocaine non-competitively inhibits the binding of Ca-ATPase to Ca ²⁺, with an IC₅₀ of 47.1 mM. Benzocaine exerts anesthetic effects by blocking voltage-gated sodium channels. Benzocaine induces methemoglobinemia in various experimental animals .

HY-B0517

Mepivacaine 1 Publications Verification	Sodium Channel	Neurological Disease
Mepivacaine is an amide-type local anesthetic agent. Mepivacaine binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization .

HY-Y1314

Dimethyl sulfone 3 Publications Verification	Bacterial	Metabolic Disease
Dimethyl sulfone (Methyl Sulfonyl Methane) is a metabolic product of endogenous methanethiol metabolism and intestinal bacterial metabolism. Dimethyl sulfone inhibits choriocapillary endothelial (CCE) cell proliferation, also has many biological effects, including antiinflammatory, antioxidant, and local anesthetic effects that could be neuroprotective .

HY-B0379A

Adiphenine hydrochloride 3 Publications Verification	nAChR	Neurological Disease
Adiphenine hydrochloride is a non-competitive inhibitor of nicotinic acetylcholine receptor (nAChR), with an IC₅₀s of 1.9, 1.8, 3.7, and 6.3 μM for α1, α3β4, α4β2, and α4β4, respectively. Adiphenine hydrochloride has anticonvulsant effects .

HY-B0405A

Bupivacaine hydrochloride 4 Publications Verification	iGluR Sodium Channel Calcium Channel Potassium Channel	Neurological Disease Cancer
Bupivacaine hydrochloride is a NMDA receptor inhibitor.Bupivacaine can block sodium, L-calcium, and potassium channels.Bupivacaine potently blocks SCN5A channels with the IC₅₀ of 69.5 μM. Bupivacaine hydrochloride can be used for the research of chronic pain .

HY-B1551

Benzonatate Benzononatine	Sodium Channel	Neurological Disease
Benzonatate (Benzononatine) is an orally active and non-narcotic peripheral antitussive agent. Benzonatate is a reversible voltage-gated Na ⁺ channels inhibitor. Benzonatate dampens the activity of cough stretch receptors .

HY-B1704

Nisoxetine 1 Publications Verification	Monoamine Transporter Sodium Channel	Neurological Disease
Nisoxetine is a potent and selective inhibitor of noradrenaline transporter (NET), with a K_d of 0.76 nM. Nisoxetine is an antidepressant and local anesthetic, it can block voltage-gated sodium channels .

HY-Y0258A

Benzocaine (hydrochloride) 1 Publications Verification	Sodium Channel Calcium Channel	Neurological Disease
Benzocaine hydrochloride is an orally active local anesthetic. Benzocaine hydrochloride non-competitively inhibits the binding of Ca-ATPase to Ca ²⁺, with an IC₅₀ of 47.1 mM. Benzocaine hydrochloride exerts anesthetic effects by blocking voltage-gated sodium channels. Benzocaine hydrochloride induces methemoglobinemia in various experimental animals .

HY-66012

Proparacaine hydrochloride 2 Publications Verification Proxymetacaine hydrochloride	Sodium Channel	Neurological Disease
Proparacaine (Proxymetacaine) hydrochloride is a local anesthetic. Proparacaine hydrochloride blocks voltage-gated sodium channels on neuronal cell membranes, thereby inhibiting signal conduction and nociceptive signal transmission. Proparacaine hydrochloride blocks nociceptive signals in the eye and induces ocular muscle relaxation to reduce eye movement during surgery. Proparacaine hydrochloride is used in research related to cataracts .

HY-B0517A

Mepivacaine hydrochloride 1 Publications Verification	Sodium Channel	Neurological Disease
Mepivacaine hydrochloride binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization .

HY-B1007

Butacaine 2 Publications Verification	Sodium Channel	Neurological Disease
Butacaine is a reversible nerve conduction blocker. Butacaine acts on the nervous system and nerve fibers, can cause both sensory and motor paralysis. Butacaine inhibits the NavBh currents. Butacaine can form inclusion complexes with α-cyclodextrin (α-CD) and β-cyclodextrin (β-CD). Butacaine is commonly used as a negative control for other local anesthetics .

HY-B0516

Articaine hydrochloride Hoe-045	Sodium Channel NF-κB NOD-like Receptor (NLR)	Neurological Disease Inflammation/Immunology
Articaine (Hoe-045) hydrochloride is a selective inhibitor of voltage-gated sodium channels (such as rNav1.4, hNav1.7, and rNav1.8), with an IC₅₀ of 15.8 μM for open-state Na ⁺ channels, and IC₅₀ of 40.6 μM and 378 μM for inactivated and resting-state Na ⁺ channels, respectively. Articaine hydrochloride exerts local anesthetic activity by inhibiting Na ⁺ influx to block nerve impulse conduction, and can also inhibit NF-κB activation and NLRP3 inflammasome pathways, exhibiting anti-inflammatory function. Articaine hydrochloride can be used in the study of dental local anesthesia and inflammatory-related diseases (such as acute kidney injury) .

HY-B1704A

Nisoxetine hydrochloride 1 Publications Verification	Monoamine Transporter Sodium Channel	Neurological Disease
Nisoxetine hydrochloride is a potent and selective inhibitor of noradrenaline transporter (NET), with a K_d of 0.76 nM. Nisoxetine hydrochloride is an antidepressant and local anesthetic, it can block voltage-gated sodium channels .

HY-B1032

Dropropizine (±)-Dropropizine; UCB-196	Histamine Receptor	Neurological Disease
Dropropizine ((±)-Dropropizine; UCB-196) is an orally effective, peripherally selective antitussive that inhibits the activity of peripheral receptors and afferent nerves in the respiratory tract. Dropropizine acts on the cough reflex pathway, does not pass the blood-brain barrier, and has no central nervous system side effects. Dropropizine mainly regulates the level of sensory neuropeptides and inhibits the afferent signal transmission of the cough reflex, thereby alleviating the symptoms of dry cough, and has both mild local anesthetic and antihistamine activity. Dropropizine is mainly used for symptomatic research on dry cough caused by respiratory diseases .

HY-121870

Dimethocaine Larocaine	Drug Derivative Cytochrome P450	Neurological Disease
Dimethocaine (Larocaine) is a cocaine derivative and ester-type local anesthetic. Dimethocaine is metabolized by hP450 1A2, 2C19, 2D6, and 3A4 in vitro. Dimethocaine exhibits locomotor-promoting, reinforcing, and anxiogenic effects .

HY-45509

TLB 150 Benzoate RAD150	Androgen Receptor	Neurological Disease
TLB 150 Benzoate (RAD150) is a nonsteroidal androgen receptor modulator with an IC₅₀ value of 0.13 μM. TLB 150 Benzoate spontaneously cyclizes under physiological conditions to form RAD 179, resulting in a persistent, reversible, and slow neuronal conduction blockade. TLB 150 Benzoate can be used for research on neurological diseases .

HY-B0985A

Phenazopyridine 2 Publications Verification	TRP Channel	Neurological Disease
Phenazopyridine is a competitive SARM1 inhibitor, with IC₅₀ 145 μM. Phenazopyridine is a TRPM8 antagonist. Phenazopyridine has a local anesthetic/analgesic effect. Phenazopyridine is used to relieve painful symptoms of conditions such as cystitis and urethritis. Phenazopyridine can promote neuronal differentiation and can also be used in the study of traumatic brain injury, peripheral neuropathy and neurodegenerative diseases .

HY-116548

Nitracaine	Dopamine Receptor	Neurological Disease
Nitracaine is a structural analog of Dimethocaine (HY-121870), a local anesthetic that inhibits dopamine reuptake through the dopamine transporter .

HY-B0405S

Bupivacaine-d9	Isotope-Labeled Compounds iGluR Sodium Channel Calcium Channel Potassium Channel	Neurological Disease
Bupivacaine-d₉9 is a deuterium labeled Bupivacaine. Bupivacaine is a NMDA receptor inhibitor.Bupivacaine can block sodium, L-calcium, and potassium channels.Bupivacaine potently blocks SCN5A channels with the IC₅₀ of 69.5 μM. Bupivacaine can be used for the research of chronic pain .

HY-B2080

Etidocaine EDC	Sodium Channel	Infection Others
Etidocaine (EDC) is a long aminoamide local *anesthetic* .

HY-19699

1-Naphthylacetamide NAAM; 1-Naphthaleneacetamide; α-Naphthylacetamide	Environmental Pollutants Phytohormone	Neurological Disease Endocrinology
1-Naphthylacetamide is an orally active nonsteroidal anti-inflammatory agent (NAIA) and also an indole-type auxin plant growth regulator. 1-Naphthylacetamide inhibits inflammatory response-related pathways and modulates plant hormone signaling, exhibiting anti-inflammatory, local anesthetic, antispasmodic, analgesic, and diuretic activities. 1-Naphthylacetamide promotes plant cell expansion, differentiation, and fruit enlargement. Additionally, 1-Naphthylacetamide induces central nervous system (CNS) depression in mice, characterized by reduced spontaneous activity, decreased irritability, decreased muscle tone, and attenuated ear-cuff reflex, ipsilateral flexor reflex, and corneal reflex ^[1][2].

HY-Z6848

(R)-(+)-Bupivacaine hydrochloride	Sodium Channel	Neurological Disease
(R)-(+)-Bupivacaine hydrochloride is a voltage-gated sodium channel inhibitor. (R)-(+)-Bupivacaine hydrochloride can selectively block the voltage-gated sodium channels on nerve cell membranes, inhibit the influx of sodium ions, and thus prevent the generation and conduction of nerve impulses, exerting local anesthetic activity. (R)-(+)-Bupivacaine hydrochloride can be used in research of acute pains .

HY-W005637

Orthocaine	Others	Neurological Disease
Orthocaine is a local agent that can suppress or relieve pain (extracted from patent WO2002089849A1) .

HY-B1755

Risocaine Propyl 4-aminobenzoate	Biochemical Assay Reagents	Neurological Disease
Risocaine, also known as Propyl 4-aminobenzoate, with potential neuroleptic properties .

HY-Y0258R

Benzocaine (Standard) 1 Publications Verification	Reference Standards Sodium Channel Bacterial	Neurological Disease
Benzocaine (Standard) is the analytical standard of Benzocaine (HY-Y0258). This product is intended for research and analytical applications. Benzocaine is an orally active local anesthetic. Benzocaine non-competitively inhibits the binding of Ca-ATPase to Ca ²⁺, with an IC₅₀ of 47.1 mM. Benzocaine exerts anesthetic effects by blocking voltage-gated sodium channels. Benzocaine induces methemoglobinemia in various experimental animals .

HY-B0517S

Mepivacaine-d3	Sodium Channel	Neurological Disease
Mepivacaine-d₃ is the deuterium labeled Mepivacaine. Mepivacaine is an amide-type local anesthetic agent. Mepivacaine binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization .

HY-B0516A

Articaine Hoe-045 free base	Sodium Channel NF-κB NOD-like Receptor (NLR)	Neurological Disease Inflammation/Immunology
Articaine (Hoe-045) is a selective inhibitor of voltage-gated sodium channels (such as rNav1.4, hNav1.7, and rNav1.8), with an IC₅₀ of 15.8 μM for open-state Na ⁺ channels, and IC₅₀ of 40.6 μM and 378 μM for inactivated and resting-state Na ⁺ channels, respectively. Articaine exerts local anesthetic activity by inhibiting Na ⁺ influx to block nerve impulse conduction, and can also inhibit NF-κB activation and NLRP3 inflammasome pathways, exhibiting anti-inflammatory function. Articaine can be used in the study of dental local anesthesia and inflammatory-related diseases (such as acute kidney injury) .

HY-Y0258AR

Benzocaine (hydrochloride) (Standard)	Reference Standards Bacterial Sodium Channel	Neurological Disease
Benzocaine hydrochloride (Standard) is an analytical standard of Benzocaine hydrochloride (HY-Y0258A). This product is intended for research and analytical applications. Benzocaine hydrochloride is an orally active local anesthetic. Benzocaine hydrochloride non-competitively inhibits the binding of Ca-ATPase to Ca ²⁺, with a IC₅₀ of 47.1 mM. Benzocaine hydrochloride exerts anesthetic effects by blocking voltage-gated sodium channels. Benzocaine hydrochloride induces methemoglobinemia in various experimental animals .

HY-118833

RAC 109	Calcium Channel	Cardiovascular Disease
RAC 109 is a local anesthetic. RAC 109 reduces ventricular conduction velocity and myocardial contractility in rabbits in a stereospecific manner (EC₅₀=30 μM) .

HY-B0517R

Mepivacaine (Standard)	Reference Standards Sodium Channel	Neurological Disease
Mepivacaine (Standard) is the analytical standard of Mepivacaine. This product is intended for research and analytical applications. Mepivacaine is an amide-type local anesthetic agent. Mepivacaine binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization .

HY-122364

Bucumolol hydrochloride	Adrenergic Receptor	Cardiovascular Disease
Bucumolol hydrochloride is a β-adrenergic receptor antagonist that can slow heart rate (negative chronotropic effect) and reduce cardiac contractility (negative inotropic effect). Bucumolol hydrochloride has antiarrhythmic and local anesthetic activity and can be used in the study of cardiovascular diseases .

HY-15736

Sodium Channel inhibitor 1	Sodium Channel	Neurological Disease
Sodium Channel inhibitor 1 is a state-dependent voltage-gated Na_V1.7 inhibitor with an IC₅₀ of 0.087 μM. Sodium Channel inhibitor 1 can be used for research of pain .

HY-Y1314R

Dimethyl sulfone (Standard)	Drug Metabolite Reference Standards Endogenous Metabolite	Metabolic Disease
Dimethyl sulfone (Standard) is the analytical standard of Dimethyl sulfone. This product is intended for research and analytical applications. Dimethyl sulfone (Methyl Sulfonyl Methane) is a metabolic product of endogenous methanethiol metabolism and intestinal bacterial metabolism. Dimethyl sulfone inhibits choriocapillary endothelial (CCE) cell proliferation, also has many biological effects, including antiinflammatory, antioxidant, and local anesthetic effects that could be neuroprotective .

HY-B1704R

Nisoxetine (Standard)	Monoamine Transporter Sodium Channel	Neurological Disease
Nisoxetine (Standard) is the analytical standard of Nisoxetine. This product is intended for research and analytical applications. Nisoxetine is a potent and selective inhibitor of noradrenaline transporter (NET), with a Kd of 0.76 nM. Nisoxetine is an antidepressant and local anesthetic, it can block voltage-gated sodium channels .

HY-105525A

Sameridine hydrochloride NIH 10908	Opioid Receptor	Others
Sameridine hydrochloride is a local anesthetic and local analgesic .

HY-121891

Rhinocaine	Others	Others
Rhinocaine is a compound with local anesthetic activity.

HY-105613

Metabutoxycaine	Others	Others
Metabutoxycaine is a local agent that can suppress or relieve pain .

HY-16259

Indecainide hydrochloride Ricainide hydrochloride; LY 135837	Sodium Channel	Cardiovascular Disease
Indecainide hydrochloride is a potent and orally active class I local anesthetic antiarrhythmic agent. Indecainide hydrochloride has Na ⁺-channel-blocking activity .

HY-105651A

Butalamine hydrochloride	Cholinesterase (ChE)	Cardiovascular Disease
Butalamine (hydrochloride) is a peripheral vasodilator with local anesthetic effects. :Butalamine (hydrochloride) can produce in animals coronary vasodilation, local anaesthesia, analgesia and a papaverine like action in duodenal preparations. Butalamine (hydrochloride) causes a slowing in rate of spontaneous activity, a decrease in amplitude and a reduction in isolated human smooth muscle .

HY-119913

Dacemazine Ahistan	Histamine Receptor	Neurological Disease
Dacemazine (Ahistan) is a phenothiazine derivative that acts as a histamine H1 receptor antagonist. Dacemazine exhibits local anesthetic activity and can alleviate spasms induced by acetylcholine and histamine .

HY-106495

Vadocaine OR K-242	Adrenergic Receptor	Neurological Disease
Vadocaine (OR K-242), an orally active antitussive compound, is a local agent that can suppress or relieve pain .

HY-Y0258S

Benzocaine-d4	Isotope-Labeled Compounds Sodium Channel	Neurological Disease
Benzocaine-d₄ is the deuterium labeled Benzocaine (HY-Y0258). Benzocaine is an orally active local anesthetic. Benzocaine non-competitively inhibits the binding of Ca-ATPase to Ca ²⁺, with an IC₅₀ of 47.1 mM. Benzocaine exerts anesthetic effects by blocking voltage-gated sodium channels. Benzocaine induces methemoglobinemia in various experimental animals .

HY-Y0258S1

Benzocaine-(ethyl-d5)	Sodium Channel	Neurological Disease
Benzocaine-(ethyl-d₅) is the deuterium labeled Benzocaine (HY-Y0258). Benzocaine is an orally active local anesthetic. Benzocaine non-competitively inhibits the binding of Ca-ATPase to Ca ²⁺, with an IC₅₀ of 47.1 mM. Benzocaine exerts anesthetic effects by blocking voltage-gated sodium channels. Benzocaine induces methemoglobinemia in various experimental animals .

HY-105651AR

Butalamine hydrochloride (Standard)	Cholinesterase (ChE) Reference Standards	Cardiovascular Disease
Butalamine (hydrochloride) (Standard) is the analytical standard of Butalamine (hydrochloride). This product is intended for research and analytical applications. Butalamine (hydrochloride) is a peripheral vasodilator with local anesthetic effects. :Butalamine (hydrochloride) can produce in animals coronary vasodilation, local anaesthesia, analgesia and a papaverine like action in duodenal preparations. Butalamine (hydrochloride) causes a slowing in rate of spontaneous activity, a decrease in amplitude and a reduction in isolated human smooth muscle .

HY-121141

Adiphenine	nAChR	Neurological Disease
Adiphenine is a non-competitive inhibitor of nicotinic acetylcholine receptor (nAChR), with an IC₅₀s of 1.9, 1.8, 3.7, and 6.3 μM for α1, α3β4, α4β2, and α4β4, respectively. Adiphenine has anticonvulsant effects .

HY-123287

Soquinolol	Adrenergic Receptor	Cardiovascular Disease
Soquinolol is a β adrenergic receptor antagonist. Soquinolol plays an important role in cardiac failure research .

HY-B0379AR

Adiphenine hydrochloride (Standard)	Reference Standards nAChR	Neurological Disease
Adiphenine (hydrochloride) (Standard) is the analytical standard of Adiphenine (hydrochloride). This product is intended for research and analytical applications. Adiphenine hydrochloride is a non-competitive inhibitor of nicotinic acetylcholine receptor (nAChR), with an IC50s of 1.9, 1.8, 3.7, and 6.3 μM for α1, α3β4, α4β2, and α4β4, respectively. Adiphenine hydrochloride has anticonvulsant effects .

Cat. No.	Product Name

HY-L071

Alkaloids Library

599 compounds

Alkaloids are a large and complex group of cyclic compounds that contain N. About 2,000 different alkaloids have been isolated. Important alkaloids include morphine, strychnine, atropine, colchicine, ephedrine, quinine, and nicotine. Alkaloids are useful as diet ingredients, supplements, and pharmaceuticals, in medicine and in other applications in human life. They showed anti-inflammatory, anticancer, analgesics, local anesthetic and pain relief, neuropharmacologic, antimicrobial, antifungal, and many other activities. Alkaloids are also important compounds in organic synthesis for searching new semisynthetic and synthetic compounds with possibly better biological activity than parent compounds.

MCE designs a unique collection of 599 alkaloids that all come from natural products. MCE Alkaloids Library is a useful tool for drug discovery that can be used for high throughput screening (HTS) and high content screening (HCS).

Cat. No.	Product Name	Category	Target	Chemical Structure