136-40-3
136-40-3
Chemical Structure
Phenazopyridine hydrochloride
- CAS 番号: 136-40-3
- Formula:C11H12ClN5
- Molecular Weight:249.70
IUPAC Name: (E)-3-(phenyldiazenyl)pyridine-2,6-diamine hydrochloride
InChIKey: QQBPIHBUCMDKFG-GEEYTBSJSA-N
SMILES: NC1=NC(N)=CC=C1/N=N/C2=CC=CC=C2.[H]Cl
Biological Activity: Phenazopyridine hydrochlorideis a competitive SARM1 inhibitor, with IC50 145 μM. Phenazopyridine hydrochlorideis a TRPM8 antagonist. Phenazopyridine hydrochloride has a local anesthetic/analgesic effect. Phenazopyridine hydrochlorideis used to relieve painful symptoms of conditions such as cystitis and urethritis. Phenazopyridine hydrochloridecan promote neuronal differentiation and can also be used in the study of traumatic brain injury, peripheral neuropathy and neurodegenerative diseases[1][2][3][4][5].
| 製品番号 | 製品名 | 純度 | 製品説明 | Pricing | |||||||||||||||||||
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Phenazopyridine hydrochloride | 99.77% | Phenazopyridine hydrochlorideis a competitive SARM1 inhibitor, with IC50 145 μM. Phenazopyridine hydrochlorideis a TRPM8 antagonist. Phenazopyridine hydrochloride has a local anesthetic/analgesic effect. Phenazopyridine hydrochlorideis used to relieve painful symptoms of conditions such as cystitis and urethritis. Phenazopyridine hydrochloridecan promote neuronal differentiation and can also be used in the study of traumatic brain injury, peripheral neuropathy and neurodegenerative diseases. | ||||||||||||||||||||
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Phenazopyridine hydrochloride (Standard) | 99.96% | Phenazopyridine (hydrochloride) (Standard) is the analytical standard of Phenazopyridine (hydrochloride). This product is intended for research and analytical applications. Phenazopyridine hydrochlorideis a competitive SARM1 inhibitor, with IC50 145 μM. Phenazopyridine hydrochlorideis a TRPM8 antagonist. Phenazopyridine hydrochloride has a local anesthetic/analgesic effect. Phenazopyridine hydrochlorideis used to relieve painful symptoms of conditions such as cystitis and urethritis. Phenazopyridine hydrochloridecan promote neuronal differentiation and can also be used in the study of traumatic brain injury, peripheral neuropathy and neurodegenerative diseases. | ||||||||||||||||||||
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SIB-1757 (Standard) | ≥98% | SIB-1757 (Standard) is the analytical standard of SIB-1757 (HY-102095). This product is intended for research and analytical applications. SIB-1757 is a highly selective and noncompetitive antagonist of mGlu5 receptor with an IC50 of 0.4 μM. | ||||||||||||||||||||
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Sudan orange G (Standard) | ≥98% | Sudan orange G (Standard) is the analytical standard of Sudan orange G. This product is intended for research and analytical applications. Sudan orange G is an azo dye. Sudan orange G, after enzymatic oxidation, generates oligomers and even polymers through free radical coupling reactions. | ||||||||||||||||||||
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Phenazopyridine | 99.93% | Phenazopyridine is a competitive SARM1 inhibitor, with IC50 145 μM. Phenazopyridine is a TRPM8 antagonist. Phenazopyridine has a local anesthetic/analgesic effect. Phenazopyridine is used to relieve painful symptoms of conditions such as cystitis and urethritis. Phenazopyridine can promote neuronal differentiation and can also be used in the study of traumatic brain injury, peripheral neuropathy and neurodegenerative diseases. | ||||||||||||||||||||
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Chrysoidine G free base | Chrysoidine G free base (Solvent Orange 3; Basic Orange 2 free base) is an industrial azo dye. Chrysoidine G free base is used in most textile dyeing, absorption fluorescent probes, and colorimetric sensors. Chrysoidine G free base can chemically complex with Co2+, or bind with Cs+ to inhibit the intramolecular charge transfer process, thereby triggering a red shift in the absorption spectrum and producing a significant color change. Chrysoidine G free base can induce DNA damage, and has moderate toxicity and carcinogenicity. | |||||||||||||||||||||
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Chrysoidine G | 99.60% | Chrysoidine G (Solvent Orange 3 hydrochloride; Basic Orange 2) is an industrial azo dye. Chrysoidine G is used in most textile dyeing, absorption fluorescent probes, and colorimetric sensors. Chrysoidine G can chemically complex with Co2+, or bind with Cs+ to inhibit the intramolecular charge transfer process, thereby triggering a red shift in the absorption spectrum and producing a significant color change. Chrysoidine G can induce DNA damage, and has moderate toxicity and carcinogenicity. | ||||||||||||||||||||
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Methyl yellow | Methyl yellow (Solvent Yellow 2) is a pH indicator. Methyl yellow appears red at low pH, and becomes yellow above pH 4.0. | |||||||||||||||||||||
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2-Methyl-5-(p-tolyldiazenyl)aniline | 98.02% | 2-Methyl-5-(p-tolyldiazenyl)aniline is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | ||||||||||||||||||||
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4-(Phenyldiazenyl)benzoic acid | 99.19% | 4-(Phenyldiazenyl)benzoic acid is a photosensitive and photoswitchable TRPA1 agonist that can be used as pharmacological tools for study of pain signaling. | ||||||||||||||||||||
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1-(2,5-Dibromophenyl)-2-phenyldiazene | 1-(2,5-Dibromophenyl)-2-phenyldiazene is a metal-organic framework (MOF). | |||||||||||||||||||||
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Chrysoidine R | Chrysoidine R is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | |||||||||||||||||||||
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References
- [1]. Loring H S, et al. Identification of the first noncompetitive SARM1 inhibitors[J]. Bioorganic & Medicinal Chemistry, 2020, 28(18): 115644. [Content Brief]
- [2]. Wang C, et al. Phenazopyridine promotes RPS23RG1/Rps23rg1 transcription and ameliorates Alzheimer-associated phenotypes in mice[J]. Neuropsychopharmacology, 2022, 47(12): 2042-2050. [Content Brief]
- [3]. Aizawa N, et al. Effects of phenazopyridine on rat bladder primary afferent activity, and comparison with lidocaine and acetaminophen[J]. Neurourology and Urodynamics, 2010, 29(8): 1445-1450. [Content Brief]
- [4]. Luyts N, et al. Inhibition of TRPM8 by the urinary tract analgesic drug phenazopyridine[J]. European Journal of Pharmacology, 2023, 942: 175512. [Content Brief]
- [5]. Suter, David M et al. Phenazopyridine hydrochlorideinduces and synchronizes neuronal differentiation of embryonic stem cells. Journal of cellular and molecular medicine vol. 13,9B (2009): 3517-27. [Content Brief]
