5875-06-9
5875-06-9
Chemical Structure
Proparacaine hydrochloride
Synonym(s): Proxymetacaine hydrochloride
- CAS No.: 5875-06-9
- Formula:C16H27ClN2O3
- Molecular Weight:330.85
IUPAC Name: 2-(diethylamino)ethyl 3-amino-4-propoxybenzoate hydrochloride
InChIKey: BFUUJUGQJUTPAF-UHFFFAOYSA-N
SMILES: O=C(OCCN(CC)CC)C1=CC=C(OCCC)C(N)=C1.Cl
Biological Activity: Proparacaine (Proxymetacaine) hydrochloride is a local anesthetic. Proparacaine hydrochloride blocks voltage-gated sodium channels on neuronal cell membranes, thereby inhibiting signal conduction and nociceptive signal transmission. Proparacaine hydrochloride blocks nociceptive signals in the eye and induces ocular muscle relaxation to reduce eye movement during surgery. Proparacaine hydrochloride is used in research related to cataracts[1][2][3].
| Cat. No. | Nom du produit | Pureté | Description | Pricing | |||||||||||||||||||
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Proparacaine hydrochloride | 99.82% | Proparacaine (Proxymetacaine) hydrochloride is a local anesthetic. Proparacaine hydrochloride blocks voltage-gated sodium channels on neuronal cell membranes, thereby inhibiting signal conduction and nociceptive signal transmission. Proparacaine hydrochloride blocks nociceptive signals in the eye and induces ocular muscle relaxation to reduce eye movement during surgery. Proparacaine hydrochloride is used in research related to cataracts. | ||||||||||||||||||||
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Proparacaine hydrochloride (Standard) | ≥98% | Proparacaine hydrochloride (Standard) is the analytical standard of Proparacaine hydrochloride (HY-66012). This product is intended for research and analytical applications. Proparacaine hydrochloride is a local anesthetic. Proparacaine hydrochloride blocks voltage-gated sodium channels on neuronal cell membranes, thereby inhibiting signal conduction and nociceptive signal transmission. Proparacaine hydrochloride blocks nociceptive signals in the eye and induces ocular muscle relaxation to reduce eye movement during surgery. Proparacaine hydrochloride is used in research related to cataracts. | ||||||||||||||||||||
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Metabutoxycaine | Metabutoxycaine is a local agent that can suppress or relieve pain. | |||||||||||||||||||||
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Parethoxycaine hydrochloride | Parethoxycaine hydrochloride is an anesthetic with nerve conduction blocking activity. Parethoxycaine hydrochloride exhibits non-selective inhibitory effects on responses to various stimulants in rat vas deferens and guinea pig ileum muscles. Parethoxycaine hydrochloride has an enhanced effect on the action of norepinephrine, and its methyl bromide derivative also exhibits the same properties on the action of norepinephrine and potassium ions. Derivatives of parethoxycaine hydrochloride have significant effects on calcium dose-response curves, displaying different tissue and stimulant selectivities. The mechanism of action of Parethoxycaine hydrochloride involves the regulation of calcium transport processes. | |||||||||||||||||||||
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Parethoxycaine | Parethoxycaine (Intracaine) is an ester-type local anesthetic that possesses dual activities as a non-selective inhibitor and agonist potentiator in smooth muscle, while acting as a mixed-type inhibitor of cytochrome c oxidase at the enzyme level. Parethoxycaine non-competitively inhibits the contraction of guinea pig ileal longitudinal muscle by interfering with transmembrane Ca2+ transport (blocking K+/CD responses in an equi-effective manner), and potentiates norepinephrine (NA) responses in rat vas deferens by blocking NA uptake and promoting Ca2+ mobilization (increasing the maximum amplitude without affecting K+ responses). Parethoxycaine inhibits the activity of purified cytochrome c oxidase in a concentration-dependent manner, and can be used in research focusing on Ca2+ signal transduction, smooth muscle contraction regulation, and mitochondrial energy metabolism. | |||||||||||||||||||||
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Proparacaine | Proparacaine (Proxymetacaine) is a local anesthetic. Proparacaine blocks voltage-gated sodium channels on neuronal cell membranes, thereby inhibiting signal conduction and nociceptive signal transmission. Proparacaine blocks nociceptive signals in the eye and induces ocular muscle relaxation to reduce eye movement during surgery. Proparacaine is used in research related to cataracts. | |||||||||||||||||||||
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Procaine | 99.79% | Procaine is a DNA-demethylating agent. Procaine acts through multiple targets and has a slow onset and a short duration of action. | ||||||||||||||||||||
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Procaine hydrochloride | 97.92% | Procaine hydrochloride is a DNA-demethylating agent. Procaine hydrochloride acts through multiple targets and has a slow onset and a short duration of action. | ||||||||||||||||||||
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Propoxycaine hydrochloride | 99.70% | Propoxycaine hydrochloride is a voltage-gated sodium channel inhibitor. Propoxycaine hydrochloride delays monophasic A spike action potential recovery. Propoxycaine hydrochloride increases bulk lateral, rotational, and annular lipid fluidity in neuronal membrane lipid bilayers, with greater inner monolayer fluidization, and induces membrane protein clustering. Propoxycaine hydrochloride can be used for the research of pain. | ||||||||||||||||||||
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Oxybuprocaine | 99.70% | Oxybuprocaine is a short-acting ester anesthetic. Oxybuprocaine binds to sodium channels and reversibly stabilizes neuronal membranes. Oxybuprocaine has cutaneous analgesic properties. Oxybuprocaine is less potent than Bupivacaine (HY-B0405) at producing central nervous system and cardiovascular toxicity. Oxybuprocaine can be used in ophthalmology and otolaryngology. | ||||||||||||||||||||
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Oxybuprocaine hydrochloride (Standard) | ≥98% | Oxybuprocaine (hydrochloride) (Standard) is the analytical standard of Oxybuprocaine (hydrochloride). This product is intended for research and analytical applications. Oxybuprocaine hydrochloride (Benoxinate hydrochloride) reversibly blocks sodium channels and prevents propagation of painful nerve impulses in the cornea, conjunctiva, and sclera. Oxybuprocaine hydrochloride is used especially in ophthalmology and otolaryngology. | ||||||||||||||||||||
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Chloroprocaine hydrochloride | 99.89% | Chloroprocaine hydrochloride (2-Chloroprocaine hydrochloride) is a potent inhibitor of Na,K-ATPase activity with an IC50 of 13 mM. Chloroprocaine hydrochloride blocks peripheral nerve. | ||||||||||||||||||||
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References
- [1]. Çalışkan B, et al. The effect of brimonidine and proparacaine on metabolic enzymes: Glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, and glutathione reductase. Biotechnol Appl Biochem. 2022;69(1):281-288. [Content Brief]
- [2]. Dang A, et al. An Analysis of the Use of Proparacaine in Cataract Surgery. Cureus. 2022;14(2):e22175. Published 2022 Feb 13. [Content Brief]
- [3]. Chen YW, et al. Adding Dopamine to Proxymetacaine or Oxybuprocaine Solutions Potentiates and Prolongs the Cutaneous Antinociception in Rats. Anesth Analg. 2018;126(5):1721-1728. [Content Brief]
