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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
107 Results for "
MG degrader-3
" in MedChemExpress (MCE) Product Catalog:
Products (107)
107 Results for "MG degrader-3" in MCE Product Catalog:
Cat. No.: HY-177728
CAS No.: 2413733-73-8
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MG degrader 3 is a molecular glue degrader that induces the degradation of multiple proteins including GSPT1, ZFP91 and CK1α via the ubiquitin-proteasome system, regulates protein stability and cellular signaling networks, and exhibits anti-proliferative activity against multiple myeloma cells. MG degrader 3 can be applied in the research of multiple myeloma .
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ML-9 is a selective and potent inhibitor of Akt kinase, inhibits myosin light-chain kinase (MLCK) and stromal interaction molecule 1 (STIM1) activity . ML-9 inhibits inhibits MLCK, PKA and PKC activity with Ki values of 4, 32 and 54 μM, respectively . ML-9 induces autophagy by stimulating autophagosome formation and inhibiting their degradation .
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1 Cited Publications
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PROTAC ERRα Degrader-3 is a potent and selective ERRα degrader based on von Hippel-Lindau ligand. PROTAC ERRα Degrader-3 is capable of specifically degrading ERRα protein by >80% at a concentration of 30 nM. PROTAC ERRα Degrader-3 is inactive against ERRβ and ERRγ proteins .
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1 Cited Publications
PROTAC FKBP Degrader-3 is a selective FKBP PROTAC degrader with an IC50 of 1.8 nM. PROTAC FKBP Degrader-3 targets and degrades the FKBP protein by recruiting the VHL E3 ligase, and this degradation process is primarily mediated by K11 and K48 ubiquitin chain linkages. PROTAC FKBP Degrader-3 can be applied in cancer research .
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1 Cited Publications
Cat. No.: HY-114229
CAS No.: 3031993-61-7
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PROTAC BET Degrader-3 (Example C-55) is a BET PROTAC degrader and can be used in cancer research .
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Cat. No.: HY-177456
CAS No.: 3077464-19-5
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STAT6 degrader-3 is a potent, bifunctional STAT6 degrader that recruits STAT6 to an E3 ubiquitin ligase, promoting STAT6 ubiquitination and subsequently inducing its degradation. STAT6 degrader-3 can be used in research concerning STAT6-related inflammation and immune signaling .
Cat. No.: HY-164827
CAS No.: 2862772-71-0
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CDK2 degrader 3 is a selective CDK2 molecular glue-like degrader. CDK2 degrader 3 induces G1 cell cycle arrest in CCNE1-amplified cancer cells. CDK2 degrader 3 is applicable to breast cancer-related research .
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BRD4 degrader-3 is a molecular glue degrader targeting BRD4, with binding activity towards the BD1 and BD2 domains of BRD4. BRD4 degrader-3 regulates the activity of BRD4. BRD4 degrader-3 inhibits MYC expression in cancer cells. BRD4 degrader-3 suppresses cell proliferation. BRD4 degrader-3 can be used in research related to acute myeloid leukemia and prostate cancer .
Cat. No.: HY-69260
CAS No.: 137076-22-3
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tert-Butyl 4-formylpiperidine-1-carboxylate is a PROTAC linker and can be used in the synthesis of PROTAC BRM/BRG1 degrader-3 (HY-168251) .
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PROTAC IRAK4 degrader-3 is a PROTAC-induced IRAK4 degrader based on von Hippel-Lindau .
Cat. No.: HY-168054
CAS No.: 3043670-68-1
PROTAC K-Ras Degrader-3 (compound 40) is a PROTAC degrader of K-Ras with a DC50 of ≤ 1 nM against SW620 KRAS G12D, and a GI50 of ≤ 10 nM against SW620 3D cell growth. PROTAC K-Ras Degrader-3 can be utilized in cancer research, such as non-small-cell lung cancer (NSCLC) .
Cat. No.: HY-168543
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PROTAC AURKA degrader 3 is a selective AURKA PROTAC degrader, with DC50 values of 2.05, 157.85 and 43.05 nM against AURKA, AURKB and TTK, respectively. PROTAC AURKA degrader 3 exhibits cytotoxicity against acute myeloid leukemia cells. PROTAC AURKA degrader 3 can be used for research related to acute myeloid leukemia .
Cat. No.: HY-163502
CAS No.: 3033746-17-4
PROTAC STAT3 degrader-3 is a STAT3 PROTAC degrader. PROTAC STAT3 degrader-3 recruits the E3 ubiquitin ligase CRBN and induces the degradation of STAT3 protein. PROTAC STAT3 degrader-3 inhibits the proliferation of malignant tumor cells. PROTAC STAT3 degrader-3 can be used for the research of non-small cell lung cancer and liver cancer .
Cat. No.: HY-132997
CAS No.: 2471970-60-0
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PROTAC Bcl-xL degrader-3 is a potent PROTAC Bcl-xL degrader. PROTAC Bcl-xL degrader-3 forms ternary complexes with the VHL-complex and BCL-XL. PROTAC Bcl-xL degrader-3 can be used in research on acute lymphoblastic leukemia .
Cat. No.: HY-173414
CAS No.: 3109967-69-0
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PROTAC STING degrader-3 is a STING PROTAC degrader (DC50: 0.62 μM). PROTAC STING degrader-3 induces STING degradation via the ubiquitin-proteasome pathway. PROTAC STING degrader-3 exerts anti-inflammatory effects by inhibiting STING/TBK1/NF-κB signaling. PROTAC STING degrader-3 has renal protective effects and can be used in the study of acute kidney injury (AKI) .
Cat. No.: HY-176919
CAS No.: 3077385-98-6
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PROTAC STAT6 degrader-3 is a potent STAT6 PROTAC degrader with a DC50 of less than 1 nM. PROTAC STAT6 degrader-3 can be used for research on allergic/inflammatory diseases and cancer .
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PROTAC α-synuclein degrader 3 is a selective α-Synuclein PROTAC degrader. PROTAC α-synuclein degrader 3 promotes ubiquitination and degradation of α-Synuclein. PROTAC α-synuclein degrader 3 can be used in research related to Parkinson's disease and Alzheimer's disease .
Cat. No.: HY-171140
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PROTAC HDAC6 degrader 3 is a selective HDAC6 PROTAC degrader with an IC50 of 0.686 μM and shows high selectivity for HDAC6 over HDAC1-4. PROTAC HDAC6 degrader 3 recruits cereblon (CRBN) to trigger HDAC6 ubiquitination and subsequent proteasomal degradation. PROTAC HDAC6 degrader 3 selectively elevates acetylated α-tubulin levels in cancer cells, and does not induce histone H3 hyperacetylation or obvious loss of cell viability. PROTAC HDAC6 degrader 3 is applicable for research on multiple myeloma .
Cat. No.: HY-174210
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PROTAC BRD4 Degrader-3 is a potent BRD4 PROTAC degrader with DC50 values of 164 nM and 80 nM at 4 h and 24 h, respectively. PROTAC BRD4 Degrader-3 induces the ubiquitination and subsequent proteasomal degradation of BRD4 by recruiting the ubiquitin E3 ligase KLHDC2. PROTAC BRD4 Degrader-3 can be used in breast cancer research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
