3109967-69-0
Chemical Structure
PROTAC STING degrader-3
- CAS No.: 3109967-69-0
- Formula:C37H36N8O10
- Molecular Weight:752.73
InChIKey: LKDGZIRZKJXWRL-VAWYXSNFSA-N
SMILES: O=C(C1=CC=C([N+]([O-])=O)O1)NC2=CC=C(NC(/C=C/C(N3CCN(CC4CN(C5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O)CC4)CC3)=O)=O)C=C2
Biological Activity: PROTAC STING degrader-3 is a STING PROTAC degrader (DC50: 0.62 μM). PROTAC STING degrader-3 induces STING degradation via the ubiquitin-proteasome pathway. PROTAC STING degrader-3 exerts anti-inflammatory effects by inhibiting STING/TBK1/NF-κB signaling. PROTAC STING degrader-3 has renal protective effects and can be used in the study of acute kidney injury (AKI)[1].
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PROTAC STING degrader-3 | 98.04% | PROTAC STING degrader-3 is a STING PROTAC degrader (DC50: 0.62 μM). PROTAC STING degrader-3 induces STING degradation via the ubiquitin-proteasome pathway. PROTAC STING degrader-3 exerts anti-inflammatory effects by inhibiting STING/TBK1/NF-κB signaling. PROTAC STING degrader-3 has renal protective effects and can be used in the study of acute kidney injury (AKI). | ||||||||||||||||||||
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Keywords
