PROTAC BRD4 Degrader-31
PROTAC BRD4 Degrader-31 is a BRD4 PROTAC degrader with DC50 s of 164 and 80 nM at 4 h and 24 h, respectively. PROTAC BRD4 Degrader-31 potently degrades BRD4 in cells with long acting degradation kinetics.
(Pink: BRD4 ligand (HY-78695); Blue: KLHDC2 ligand (HY-174218); Black: linker (HY-174222)).
For research use only. We do not sell to patients.
- Formula: C54H62ClN7O4S
- Molecular Weight:940.63
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
All PROTACs Isoforms
More
Biological Activity
|
BRD4 164 (4 h) nM (DC50) |
BRD4 80 (80 h) nM (DC50) |
PROTAC BRD4 Degrader-31 (Compound 8) (4-24 h) significantly degrades BRD4 with DC50, 4 h: of 164 nM and DC50, 24 h of 80 nM in HEK293T cells expressing BRD4-HiBiT transgene[1].
PROTAC BRD4 Degrader-31 (0.1-10 µM, 24 h) effectively degrades endogenous BRD4 protein through a proteasome-mediated mechanism, with maximal degradation of 94% at 24 h in SK-BR-3 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:SK-BR-3 cells
-
Concentration:0.1, 0.5, 1, 5, 10 μM
-
Incubation Time:24 h
-
Result:Degraded more than 60% of endogenous BRD4 protein at 0.1 μM.
Achieved 94% maximal degradation of endogenous BRD4 protein at 10 µM.
Partially rescued the degradation effect by MG-132 (HY-13259).
Chemical Information
-
Molecular Weight 940.63
-
Formula C54H62ClN7O4S
-
SMILES
O=C(OC)C1=C2C(C(C3CCC4C3)C4C(C5=CC(OCCC6CCN(CC7CCN(C(C[C@@H]8N=C(C9=CC=C(Cl)C=C9)C(C(C)=C(C)S%10)=C%10N%11C8=NN=C%11C)=O)CC7)CC6)=CC=C5)N2)=CC=C1
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz