1 Result for "

MRLB223

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "MRLB223" in MCE Product Catalog:

Cat. No.: HY-124792
CAS No.: 937727-03-2
Target:  

HDAC Apoptosis Bcr-Abl HSP

Research Areas:  

Cancer

MRLB-223 is a preferential HDAC1 and HDAC2 inhibitor with activity against tumor cells.MRLB-223 induces histone hyperacetylation, intrinsic apoptotic pathway activation, tumor cell apoptosis, Hsp90 hyperacetylation, and caspase-dependent Bcr-Abl degradation.MRLB-223 mediates p53-independent tumor cell death, with activity suppressed by Bcl-2 overexpression, and kills Bcr-Abl-expressing myeloid cells.MRLB-223 exerts effects in mice bearing Eμ-myc lymphomas.MRLB-223 can be used for the research of Eμ-myc lymphoma .
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