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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
29 Results for "
Methylglutaryl-CoA
" in MedChemExpress (MCE) Product Catalog:
Products (29)
29 Results for "Methylglutaryl-CoA" in MCE Product Catalog:
Cat. No.: HY-CE01704
CAS No.: 76663-42-8
Synonyms: Methylglutaryl-coenzyme A
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Methylglutaryl-CoA (Methylglutaryl-coenzyme A) is a coenzyme A derivative .
2
2 Cited Publications
Cat. No.: HY-P72228
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: HMGCR; 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase; 3-Hydroxy-3-Methylglutaryl-CoA Reductase; HydroxyMethylglutaryl-CoA Reductase (NADPH); 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase; Alternative Protein HMGCR; HMG-CoA Reductase; LGMDR28; 3-Hydrox
Species:
Human
Source:
E. coli
1
1 Cited Publications
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1
Category:
Infection Microorganisms Antibiotics Disease Research Antibacterial Disease Research Fields Other Antibiotics
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1
1 Cited Publications
Cat. No.: HY-N0468
CAS No.: 63279-13-0
Category:
other families Terpenoids Metabolic Disease Diterpenoids Plants Disease Research Fields Sweeteners Food Research
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1
1 Cited Publications
Cat. No.: HY-P1108
CAS No.: 681260-70-8
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1
1 Cited Publications
Cat. No.: HY-P1108A
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1
1 Cited Publications
Cat. No.: HY-P81197
Synonyms: 3 hydroxy 3 Methylglutaryl CoA reductase antibody;
3 hydroxy 3 Methylglutaryl Coenzyme A reductase antibody;
3 hydroxyMethylglutaryl CoA reductase antibody;
3-hydroxy-3-Methylglutaryl CoA reductase (NADPH) antibody;
3-hydroxy-3-Methylglutaryl-coenzyme A reductase antibody;
3H3M antibody;
HMDH_HUMAN antibody;
HMG CoA reductase antibody;
HMG CoAR antibody;
HMG-CoA reductase antibody;
Hmgcr antibody;
HydroxyMethylglutaryl CoA reductase antibody;
LDLCQ3 antibody;
MGC103269 antibody;
Red antibody;
Cat. No.: HY-P10272
CAS No.: 1628323-80-7
Synonyms: PTG-300
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Cat. No.: HY-W414823
CAS No.: 72542-49-5
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24,25-Epoxycholesterol is an oxysterol agonist of the liver X receptor that can inhibit the activity of 3-hydroxy-3-methylglutaryl-CoA reductase (HMG-CoA reductase) in liver cells. 24,25-Epoxycholesterol regulates cholesterol metabolism in the liver .
Cat. No.: HY-P10143
CAS No.: 99828-55-4
Synonyms: Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt
Cat. No.: HY-A0248AS
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Cat. No.: HY-19671
CAS No.: 126411-13-0
Synonyms: SR-45023A; SR 9223i; SK&F-99085
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Apomine (SR-45023A) is an orally active antineoplastic agent that inhibits the mevalonate/isoprenoid pathway in cholesterol synthesis. Apomine can accelerate the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR). Apomine can also inhibit the growth of various types of cancer cells, including lung cancer, colon cancer, breast cancer, and skin cancer. Apomine is able to induce apoptosis in tumor cell lines derived from leukemia, colon cancer, liver cancer, ovarian cancer, and breast cancer .
Cat. No.: HY-P10563
CAS No.: 2580150-96-3
Synonyms: BHV-1100
Cat. No.: HY-P3066
CAS No.: 77453-01-1
Synonyms: d(CH2)5Tyr(Et)VAVP
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Cat. No.: HY-129149
CAS No.: 865543-37-9
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Cat. No.: HY-117219
CAS No.: 136209-43-3
Research Areas:
SKF 104976 is a 3,2-carboxylic acid derivative with potent 14-alpha-demethylase (14 alpha DM) inhibitory activity. SKF 104976 inhibited 14 alpha DM activity by 50% at 2 nM in Hep G2 cell extracts. SKF 104976 inhibited the incorporation of [14C]acetate into cholesterol in intact cells at similar concentrations, accompanied by accumulation of lanosterol, and resulted in a 40-70% decrease in 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) activity. SKF 104976 did not affect the uptake and degradation of low-density lipoprotein in Hep G2 cells, indicating that HMGR and low-density lipoprotein receptor activities are not coordinately regulated under these conditions. The inhibitory effect of SKF 104976 on HMGR activity remained unchanged even when the flux of carbon units in the sterol synthesis pathway was reduced by 80%. SKF 104976 did not inhibit HMGR activity under conditions where sterol synthesis was almost completely blocked by lovastatin .
Cat. No.: HY-N0468R
CAS No.: 63279-13-0
Category:
Cat. No.: HY-113725
CAS No.: 112965-15-8
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L 668411 is a β-lactone inhibitor with activity against 3-hydroxy-3-methylglutaryl-CoA synthase and cholesterol biosynthesis. L 668411 inhibits rat liver cytosolic 3-hydroxy-3-methylglutaryl-CoA synthase and [14C] acetate incorporation into sterols in cultured Hep G2 cells, and the inhibition appears to be irreversible in cells but reversible in cultured cells and animals.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
