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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
3 Results for "
NC-R17
" in MedChemExpress (MCE) Product Catalog:
Products (3)
3 Results for "NC-R17" in MCE Product Catalog:
Cat. No.: HY-155075
CAS No.: 3049087-34-2
Target:
Research Areas:
NC-R17 is a PROTAC-class, non-covalent GPX4 degrader based on RSL3, involved in ferroptosis. NC-R17 has antitumor activity and is used for non-covalent GPX4 PROTAC design . NC-R17 consists of a target protein ligand (red part) Demethyl-RSL3 (HY-135832); an E3 ubiquitin ligase ligand (blue part) Lenalidomide (HY-A0003) and a PROTAC linker (black part) (HY-169376). E3 ubiquitin ligase and linker can form Lenalidomide-C13-piperazine-Boc (HY-169377) .
Cat. No.: HY-169376
CAS No.: 2700269-84-5
Target:
Research Areas:
Boc-piperazine-C13-OTs is a PROTAC linker. Boc-piperazine-C13-OTs can be used to synthesize NC-R17 (HY-155075) .
Cat. No.: HY-169377
CAS No.: 3043895-40-2
Research Areas:
Lenalidomide-C13-piperazine-Boc is a conjugate of the E3 ligase ligand and the linker, that can be used for synthesis of PROTAC degrader NC-R17 (HY-155075) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
