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NMDA NR2B

" in MedChemExpress (MCE) Product Catalog:

By Targets:	17β-HSD (1) Adrenergic Receptor (2) Calcium Channel (2) Cholinesterase (ChE) (1) iGluR (34) Influenza Virus (2) Potassium Channel (5) Reference Standards (5) Sigma Receptor (1)
By Research Areas:	Infection (2) Inflammation/Immunology (1) Metabolic Disease (1) Neurological Disease (31)

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Targets Recommended: Progesterone Receptor FXR Constitutive Androstane Receptor Nuclear Hormone Receptor 4A/NR4A

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12882A

Ifenprodil tartrate 5+ Cited Publications NP-120 tartrate; RC-61-91 tartrate	iGluR Adrenergic Receptor Potassium Channel Calcium Channel Influenza Virus	Infection Neurological Disease
Ifenprodil (NP-120) tartrate, a cerebral vasodilator, is a noncompetitive *NMDA* receptor antagonist. Ifenprodil tartrate exerts high affinity at NR1A/NR2B receptors (IC₅₀=0.34 μM) over 400-fold than at NR1A/NR2A receptors (IC₅₀=146 μM) . Ifenprodil tartrate is an α1 adrenergic receptor antagonist. Ifenprodil tartrate inhibits GIRK (Kir3), reduces inward currents through the basal GIRK activity. Ifenprodil tartrate has reliable inhibitory effects against A/H1N1 strains (EC₅₀ of 6.6 µM). Ifenprodil tartrate has neuroprotective, anticonvulsant and antinociceptive effects. Ifenprodil tartrate can be used for the study of cerebrovascular diseases and peripheral arterial obliterative disease .

HY-14777

Radiprodil RGH-896	iGluR	Neurological Disease
Radiprodil (RGH-896) is an orally active and selective **NMDA NR2B** antagonist. A potential therapeutic agent in treatment of neuropathic pain and possibly other chronic pain conditions .

HY-13993

Ro 25-6981 5+ Cited Publications	iGluR	Neurological Disease
Ro 25-6981 is a potent, selective and activity-dependent NR2B subunit specific NMDA receptor antagonist. Ro 25-6981 shows anticonvulsant and anti-parkinsonian activity. Ro 25-6981 has the potential for the research of parkinson's disease (PD) .

HY-13993A

Ro 25-6981 Maleate 5+ Cited Publications	iGluR	Neurological Disease
Ro 25-6981 Maleate is a potent, selective and activity-dependent NR2B subunit specific NMDA receptor antagonist. Ro 25-6981 Maleat shows anticonvulsant and anti-parkinsonian activity. Ro 25-6981 Maleate has the potential for the research of parkinson's disease (PD) .

HY-12882

Ifenprodil Maximum Cited Publications 10 Publications Verification NP-120; RC-61-91	iGluR Adrenergic Receptor Potassium Channel Calcium Channel Influenza Virus	Infection Neurological Disease
Ifenprodil (NP-120), a cerebral vasodilator, is a noncompetitive *NMDA* receptor antagonist. Ifenprodil exerts high affinity at NR1A/NR2B receptors (IC₅₀=0.34 μM) over 400-fold than at NR1A/NR2A receptors (IC₅₀=146 μM) . Ifenprodil is an α1 adrenergic receptor antagonist. Ifenprodil inhibits GIRK (Kir3), reduces inward currents through the basal GIRK activity. Ifenprodil has reliable inhibitory effects against A/H1N1 strains (EC₅₀ of 6.6 µM). Ifenprodil has neuroprotective, anticonvulsant and antinociceptive effects. Ifenprodil can be used for the study of cerebrovascular diseases and peripheral arterial obliterative disease .

HY-145585

Onfasprodil MIJ-821	iGluR	Neurological Disease
Onfasprodil (MIJ-821) is a selective intravenous *NMDA* receptor *NR2B* subunit negative allosteric modulator (NAM). Onfasprodil inhibits the activity of NR2B-NMDA receptors. Onfasprodil has a rapid antidepressant effect. Onfasprodil can be used for the research of treatment-resistant depression (TRD) .

HY-107706

Co 101244 hydrochloride PD 174494 hydrochloride	iGluR	Neurological Disease
Co 101244 (PD 174494) hydrochloride is a NR2B-containing NMDA receptor antagonist .

HY-12881

Eliprodil SL-820715	iGluR	Neurological Disease
Eliprodil(SL-820715) is a non-competitive NR2B-NMDA receptor antagonist(IC50=1 uM), less potent for NR2A- and NR2C-containing receptors(IC50> 100 uM).

HY-106408

Nelonemdaz Salfaprodil free base; Neu2000	iGluR	Neurological Disease
Nelonemdaz (Salfaprodil free base) is an NR2B-selective and uncompetitive antagonist of N-methyl-D-aspartate (NMDA). Nelonemdaz is also a free radical scavenger. Nelonemdaz has excellent neuroprotection against NMDA- and free radical-induced cell death .

HY-177127

Satoprodil	iGluR	Neurological Disease
Satoprodil (example 2) is a potent N-methyl-D-aspartate (NMDA) receptor negative allosteric modulator with an IC₅₀ value of 123 nM for NR2B .

HY-12962

NMDA-IN-1	iGluR	Neurological Disease
NMDA-IN-1 is a potent and NR2B-selective NMDA antagonist with Ki of 0.85 nM; NR2B Ca2+ influx IC50 is 9.7 nM; no activities on NR2A, NR2C, NR2D, hERG-channel and α1-adrenergic receptor.

HY-126123

NR2B-selective NMDA receptor antagonist 1	iGluR Potassium Channel	Neurological Disease
NR2B-selective NMDA receptor antagonist 1 (compound 29) is a potent antagonist of NR1/NR2B receptors, with IC₅₀s of 0.05 μM, 0.73 μM, 2.4 μM to NR1/NR2B NMDA receptor, hERG, α1-AdR, respectivity. NR2B-selective NMDA receptor antagonist 1 exhibites efficient permeability across the blood–brain barrier .

HY-106408A

Nelonemdaz potassium Salfaprodil; Neu2000 potassium	iGluR	Neurological Disease
Nelonemdaz (Salfaprodil) potassium is an NR2B-selective and uncompetitive antagonist of N-methyl-D-aspartate (NMDA). Nelonemdaz potassium is also a free radical scavenger. Nelonemdaz potassium has excellent neuroprotection against NMDA- and free radical-induced cell death .

HY-121100

BZAD-01	iGluR	Neurological Disease
BZAD-01 is a potent, selective and orally active inhibitor of NMDA NR2B subunit, with a K_i of 72 nM. BZAD-01 can improve postural asymmetry as well as Apomorphine-induced rotation .

HY-137049

Co 101244 PD 174494	iGluR	Others
Co-101244 (PD 174494) is an NMDA receptor blocker that specifically targets the NR2B subunit.

HY-136659

Ro 04-5595	iGluR	Others
Ro 04-5595 is a selective antagonist with specific activity against the NR2B subunit of the NMDA receptor. Ro 04-5595 exhibits favorable pharmacokinetic properties in in vitro and in vivo studies, with rapid uptake and clearance. Ro 04-5595 exhibits strong binding in NR2B receptor-enriched regions and low binding in the cerebellum. Ro 04-5595 is able to effectively inhibit specific binding, showing high affinity for the NR2B receptor and a clear ranking of binding affinity with a variety of other compounds .

HY-107716

Ro 8-4304 hydrochloride	iGluR	Neurological Disease
Ro 8-4304 hydrochloride is a potent NMDA receptor antagonist. Ro 8-4304 hydrochloride is a NR2B selective, non-competitive, voltage-independent antagonist .

HY-170410

EMD-95885	iGluR	Neurological Disease
EMD-95885 is a selective NR2B-containing NMDA receptors antagonist with an IC₅₀ of 3.9 nM. EMD-95885 does not interact with other sites on the NMDA receptor .

HY-12882AR

Ifenprodil tartrate (Standard) NP-120 tartrate (Standard); RC-61-91 tartrate (Standard)	iGluR Potassium Channel Reference Standards	Neurological Disease
Ifenprodil (tartrate) (Standard) is the analytical standard of Ifenprodil (tartrate). This product is intended for research and analytical applications. Ifenprodil tartrate is a typical noncompetitive NMDA receptor antagonist. Ifenprodil tartrate exerts high affinity at NR1A/NR2B receptors (IC50=0.34 μM) over 400-fold than at NR1A/NR2A receptors (IC50=146 μM) . Ifenprodil tartrate inhibits GIRK (Kir3), reduces inward currents through the basal GIRK activity. Ifenprodil tartrate has the potential to be a cerebral vasodilator .

HY-107698

PMPA (NMDA antagonist)	iGluR	Neurological Disease
PMPA (NMDA antagonist) is an NMDA receptor antagonist with K_i values of 0.84, 2.74, 3.53 and 4.16 μM for NR2A, *NR2B, NR2C* and NR2D, respectively .

HY-136459

NMDA receptor antagonist 2	iGluR	Neurological Disease
NMDA receptor antagonist 2 is a potent and orally active **NR2B subtype-selective NMDA antagonist with an IC₅₀ and a K_i** of 1.0 nM and 0.88 nM, respectively. NMDA receptor antagonist 2 is used for the study of neuropathic pain and Parkinson’s disease .

HY-161211

HSD17B13-IN-7	17β-HSD iGluR	Metabolic Disease
HSD17B13-IN-7 (compound 1), a fluorophenol-containing compound, is a potent HSD17B13 inhibitor with IC₅₀s of 0.18 μM and 0.25 μM β-estradiol and Leukotriene B4 as substrates, respectively. HSD17B13-IN-7 is a potent N-methyl-D-aspartate (NMDA) NR2B receptor antagonist. HSD17B13-IN-7 has the potential for non-alcoholic fatty liver disease research .

HY-116142

CP-283097	iGluR	Neurological Disease
CP-283097 is an orally active and conformationally restricted and *NR2B* subtype-selective *NMDA* antagonist. CP-283097 efficiently competitively inhibits the binding of [³H]CP-101,606 to the rat meninges, with an IC₅₀ value of 18 nM. CP-283097 exhibits nearly complete inhibition of the current mediated by the NR2B receptor (IC₅₀ = 206 nM), while the inhibitory effect on the NR2A or NR2C receptors is very weak. CP-283097 demonstrates excellent central nervous system permeability and in vivo efficacy in animal models. CP-283097 can be used for neurological diseases related to excessive activation of NMDA receptors .

HY-14777R

Radiprodil (Standard) RGH-896 (Standard)	iGluR Reference Standards	Neurological Disease
Radiprodil (Standard) is the analytical standard of Radiprodil. This product is intended for research and analytical applications. Radiprodil (RGH-896) is an orally active and selective NMDA NR2B antagonist. A potential therapeutic agent in treatment of neuropathic pain and possibly other chronic pain conditions .

HY-13993B

Ro 25-6981 hydrochloride	iGluR	Neurological Disease
Ro 25-6981 hydrochloride is a potent, selective and activity-dependent NR2B subunit specific NMDA receptor antagonist. Ro 25-6981 hydrochloride shows anticonvulsant and anti-parkinsonian activity. Ro 25-6981 hydrochloride has the potential for the research of parkinson's disease (PD) .

HY-107706R

Co 101244 hydrochloride (Standard) PD 174494 hydrochloride (Standard)	Reference Standards iGluR	Neurological Disease
Co 101244 hydrochloride (Standard) is the analytical standard of Co 101244 (hydrochloride) (HY-107706). This product is intended for research and analytical applications. Co 101244 (PD 174494) hydrochloride is a NR2B-containing NMDA receptor antagonist .

HY-105353

CEB-1604	iGluR	Neurological Disease
CEB-1604 is an *NMDA* receptor antagonist. CEB-1604 inhibits NMDA-induced currents in oocytes transfected with NMDA receptor isoforms (NR1/NR2A, NR1/NR2B, NR1/NR2C, NR1/NR2D) with IC₅₀ values ranging from 5 to 12 μM. CEB-1604 abolishes NMDA-dependent epileptiform discharges in rat cortical wedge preparations and reduces the depolarizing effects of NMDA. CEB-1604 can be used in the research field of neurological damage diseases .

HY-117467

BMT-108908	iGluR	Neurological Disease
BMT-108908 is a negative allosteric modulator with selective activity on the NR2B subtype of the NMDA receptor. BMT-108908 has been shown to damage cognition in research, affecting cognitive functions in multiple areas. BMT-108908 failed to show a significant impact on the γ wave power of the EEG in the experiment, but it had a significant inhibitory and enhancement effect on the β wave and δ wave power .

HY-107708

threo-Ifenprodil hemitartrate	iGluR Sigma Receptor Potassium Channel	Neurological Disease
threo Ifenprodil hemitartrate is a σ receptor agonist, with K_is of 59.1 and 2 nM for σ1 and σ2 receptors, respectively. threo Ifenprodil hemitartrate is also a *NR2B* subunit-selective NMDA receptor antagonist (IC₅₀=0.22 μM). threo Ifenprodil hemitartrate is a hERG potassium channel inhibitor, with an IC ₅₀ of 88 nM, showing antiarrhythmic activity .

HY-12962A

NMDA-IN-1 dihydrochloride	iGluR	Neurological Disease
NMDA-IN-1 dihydrochloride is a selective **NMDA NR2B** antagonist with a Ki of 0.85 nM; NR2B Ca₂₊ influx IC₅₀ is 9.7 nM. NMDA-IN-1 dihydrochloride inhibits Glu/Gly stimulated Ca₂₊ flux in Ltk- cells expressing the hNR1a/NR2B with a IC₅₀ of 9.7 nM. NMDA-IN-1 dihydrochloride has no activities on NR2A, NR2C, NR2D, hERG-channel and α1-adrenergic receptor. NMDA-IN-1 dihydrochloride shows excellent activity in the mechanical hyperalgesia assay in rats. NMDA-IN-1 dihydrochloride can be used for the studies of stroke, parkinson, and neuropathic pain .

HY-106408AR

Nelonemdaz potassium (Standard) Salfaprodil (Standard); Neu2000 potassium (Standard)	Reference Standards iGluR	Neurological Disease
Nelonemdaz potassium (Standard) is the analytical standard of Nelonemdaz potassium (HY-106408A). This product is intended for research and analytical applications. Nelonemdaz (Salfaprodil) potassium is an NR2B-selective and uncompetitive antagonist of N-methyl-D-aspartate (NMDA). Nelonemdaz potassium is also a free radical scavenger. Nelonemdaz potassium has excellent neuroprotection against NMDA- and free radical-induced cell death .

HY-106408R

Nelonemdaz (Standard) Salfaprodil free base (Standard); Neu2000 (Standard)	Reference Standards iGluR	Neurological Disease
Nelonemdaz (Standard) is the analytical standard of Nelonemdaz (HY-106408). This product is intended for research and analytical applications. Nelonemdaz (Salfaprodil free base) is an NR2B-selective and uncompetitive antagonist of N-methyl-D-aspartate (NMDA). Nelonemdaz is also a free radical scavenger. Nelonemdaz has excellent neuroprotection against NMDA- and free radical-induced cell death .

HY-182628

CJ-036878	iGluR	Neurological Disease Inflammation/Immunology
CJ-036878 is a NMDAR NR2B subunit antagonist. CJ-036878 is applicable to research related to persistent inflammatory pain and neuropathic pain .

HY-185027

Memagal	Cholinesterase (ChE) iGluR	Neurological Disease
Memagal is an AchE inhibitor (IC₅₀ = 1.16 nM) and a NMDAR antagonist (K_i = 4.6 μM). Memagal inhibits the neurotoxicity induced by NMDA (HY-17551), with its IC₅₀ value being 0.28 nM. Memagal can be used for research on Alzheimer's disease .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-12882A

Ifenprodil tartrate 5+ Cited Publications NP-120 tartrate; RC-61-91 tartrate	Alkaloids Piperidine Alkaloids Neurological Disease Classification of Application Fields Crassulaceae Sedum sarmentosum Bunge Plants Disease Research Fields Source Classification	iGluR Adrenergic Receptor Potassium Channel Calcium Channel Influenza Virus
Ifenprodil (NP-120) tartrate, a cerebral vasodilator, is a noncompetitive *NMDA* receptor antagonist. Ifenprodil tartrate exerts high affinity at NR1A/NR2B receptors (IC₅₀=0.34 μM) over 400-fold than at NR1A/NR2A receptors (IC₅₀=146 μM) . Ifenprodil tartrate is an α1 adrenergic receptor antagonist. Ifenprodil tartrate inhibits GIRK (Kir3), reduces inward currents through the basal GIRK activity. Ifenprodil tartrate has reliable inhibitory effects against A/H1N1 strains (EC₅₀ of 6.6 µM). Ifenprodil tartrate has neuroprotective, anticonvulsant and antinociceptive effects. Ifenprodil tartrate can be used for the study of cerebrovascular diseases and peripheral arterial obliterative disease .

HY-12882AR

Ifenprodil tartrate (Standard) NP-120 tartrate (Standard); RC-61-91 tartrate (Standard)	Alkaloids Piperidine Alkaloids Crassulaceae Sedum sarmentosum Bunge Plants Source Classification	iGluR Potassium Channel Reference Standards
Ifenprodil (tartrate) (Standard) is the analytical standard of Ifenprodil (tartrate). This product is intended for research and analytical applications. Ifenprodil tartrate is a typical noncompetitive NMDA receptor antagonist. Ifenprodil tartrate exerts high affinity at NR1A/NR2B receptors (IC50=0.34 μM) over 400-fold than at NR1A/NR2A receptors (IC50=146 μM) . Ifenprodil tartrate inhibits GIRK (Kir3), reduces inward currents through the basal GIRK activity. Ifenprodil tartrate has the potential to be a cerebral vasodilator .

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NMDA NR2B

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