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Cat. No.: HY-137049

Co 101244

(Synonyms: PD 174494)

Co-101244 (PD 174494) is an NMDA receptor blocker that specifically targets the NR2B subunit.

For research use only. We do not sell to patients.

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

CAS No.: 193359-26-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

Co-101244 (PD 174494) is an NMDA receptor blocker that specifically targets the NR2B subunit.

All iGluR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
Oocyte	IC₅₀	>100 μM Compound: 10e	In vitro inhibitory concentration against NMDA responses at cloned NR1A/2A receptors expressed in Xenopus oocytes In vitro inhibitory concentration against NMDA responses at cloned NR1A/2A receptors expressed in Xenopus oocytes	[PMID: 10425109]
Oocyte	IC₅₀	>100 μM Compound: 10e	In vitro inhibitory concentration against NMDA responses at NR1A/2C receptors expressed in Xenopus oocytes In vitro inhibitory concentration against NMDA responses at NR1A/2C receptors expressed in Xenopus oocytes	[PMID: 10425109]
Oocyte	IC₅₀	0.043 μM Compound: 10e	In vitro inhibitory concentration against NMDA responses at NR1A/2B receptors expressed in Xenopus oocytes In vitro inhibitory concentration against NMDA responses at NR1A/2B receptors expressed in Xenopus oocytes	[PMID: 10425109]

CAS No. 193359-26-1
Molecular Weight 341.44
Formula C₂₁H₂₇NO₃
SMILES

OC1=CC=C(C=C1)OCCN2CCC(CC3=CC=C(C)C=C3)(CC2)O
Synonyms

PD 174494
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.