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10 Results for "
Nefazodone
" in MedChemExpress (MCE) Product Catalog:
Products (10)
10 Results for "Nefazodone" in MCE Product Catalog:
4
4 Cited Publications
Target:
Research Areas:
Nefazodone is an orally active phenylpiperazine antidepressant. Nefazodone can potently and selectively block postsynaptic 5-HT2A receptors, and moderately inhibit 5-HT and noradrenaline reuptake. Nefazodone can also relieve the adverse effects of stress on the the immune system of mice. Nefazodone has a high affinity for CYP3A4 isoenzyme, which indicates that it has certain risk of agent-agent interaction .
4
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Nefazodone hydrochloride (BMY-13754) is a potent and selective 5HT2A (Ki=5.8 nM) antagonist with moderate inhibition of 5-HT and noradrenaline uptake (IC50 of 290 and 300 nM, respectively). Nefazodone hydrochloride is a phenylpiperazine antidepressant with less alpha-adrenergic blocking activity .
Cat. No.: HY-156807
CAS No.: 210751-39-6
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Research Areas:
LY 367265 is a 5-hydroxytryptamine transporter (SERT) inhibitor (IC₅₀ = 3.1 nM) and a 5-HT₂A receptor antagonist (Kᵢ = 0.81 nM). LY 367265 has the inhibitory activity on the norepinephrine transporter (NET) of extremely weak (IC₅₀ > 1000 nM); it has low affinity for subtypes such as 5-HT₁B (Kᵢ = 490 nM) and 5-HT₁D (Kᵢ = 81 nM), showing high selectivity. LY 367265 concentration-dependently enhances of [³H]5-HT efflux (EC₅₀ = 250 nM). LY 367265 antagonizes the contraction response of Sumatriptan (HY-B0121B), indicating its functional antagonistic activity on 5-HT₁D-like receptors. LY 367265 can be used for the study of diseases such as anxiety disorders and post-traumatic stress disorder .
Cat. No.: HY-119209R
CAS No.: 83366-66-9
Research Areas:
Nefazodone (Standard) is the analytical standard of Nefazodone. This product is intended for research and analytical applications. Nefazodone is an orally active phenylpiperazine antidepressant. Nefazodone can potently and selectively block postsynaptic 5-HT2A receptors, and moderately inhibit 5-HT and noradrenaline reuptake. Nefazodone can also relieve the adverse effects of stress on the the immune system of mice. Nefazodone has a high affinity for CYP3A4 isoenzyme, which indicates that it has certain risk of agent-agent interaction .
Cat. No.: HY-143988S
Cat. No.: HY-B1396S3
Synonyms: BMY-13754-d; MJ-13754-1-d
Cat. No.: HY-B1396R
CAS No.: 82752-99-6
Synonyms: BMY-13754 (Standard); MJ-13754-1 (Standard)
Research Areas:
Nefazodone (hydrochloride) (Standard) is the analytical standard of Nefazodone (hydrochloride). This product is intended for research and analytical applications. Nefazodone hydrochloride (BMY-13754) is a potent and selective 5HT2A (Ki=5.8 nM) antagonist with moderate inhibition of 5-HT and noradrenaline uptake (IC50 of 290 and 300 nM, respectively). Nefazodone hydrochloride is a phenylpiperazine antidepressant with less alpha-adrenergic blocking activity .
Cat. No.: HY-B1396S1
Synonyms: BMY-13754-d6 dihydrochloride; MJ-13754-1-d6 dihydrochloride
Cat. No.: HY-B1396S
Synonyms: BMY-13754-d6; MJ-13754-1-d6
Cat. No.: HY-120618
CAS No.: 153707-88-1
Synonyms: BMS-180492
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Research Areas:
Triazoledione (BMS-180492) is a phenylpiperazine compound and the major metabolite of Nefazodone (HY-119209). Triazoledione is used in the research of depression .
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Protocols
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