2 Results for "

Nodularin

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "Nodularin" in MCE Product Catalog:

Nodularin
Nodularin
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Cat. No.: HY-P2040
CAS No.: 118399-22-7
Category:  

other families Cyclopeptides Ketones, Aldehydes, Acids Marine natural products Plants

Target:  

Phosphatase Apoptosis Caspase Bcl-2 Family p38 MAPK Ribosomal S6 Kinase (RSK) Reactive Oxygen Species (ROS)

Nodularin is a hepatotoxin, tumor promoter, and protein phosphatase inhibitor. Nodularin induces apoptosis (apoptosis) in normal cells (including caspase activation, upregulation of Bcl‑XS, and upregulation of BAX/P53), triggers hyperphosphorylation of the MAPK/ERK, mTOR/S6K and p38 MAPK signaling pathways, and induces oxidative stress, endoplasmic reticulum membrane instability, peroxisome proliferation and increased lysosomal enzyme activity. Nodularin promotes DEN (HY-N7434)-initiated hepatocyte proliferation and adenoma formation, and inhibits proliferation, phagocytosis and chemotaxis of normal lymphocytes, oocyte maturation and vitellogenesis, as well as angiogenesis. Nodularin exhibits hepatotoxicity, reproductive and endocrine toxicity, and embryonic developmental toxicity in various animal models. Nodularin can be used in studies related to liver cancer, hepatotoxicity and reproductive endocrine toxicity .
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ADDA
ADDA
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Cat. No.: HY-118274
CAS No.: 126456-06-2
Synonyms: GC 300
Target:  

Endogenous Metabolite

Research Areas:  

Others

ADDA (GC 300) is a unique C20 amino acid that is a key component of hepatotoxins produced by cyanobacteria. ADDA is essential for the toxicity of nodularin and microcystin, toxins that can cause liver damage. ADDA can be used for research in toxicology .
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