1 Result for "

OSU53

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "OSU53" in MCE Product Catalog:

Cat. No.: HY-125535
CAS No.: 1290069-19-0
Target:  

AMPK mTOR Autophagy Atg8/LC3

Research Areas:  

Cancer

OSU-53 is an orally active AMPK activator (EC50: 0.3 μM) and a direct mTOR inhibitor. OSU-53 induces autophagy and increases conversion of LC3 I to LC3 II. OSU-53 also modulates energy homeostasis by suppressing fatty acid biosynthesis and shifting the metabolism to oxidation by up-regulating the expression of PGC1α and NRF-1. OSU-53 has antitumor activity in various tumor models, such as breast cancer and thyroid cancer .
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