24 Results for "

PAR 1 Agonist

" in MedChemExpress (MCE) Product Catalog:
Products (24)

24 Results for "PAR 1 Agonist" in MCE Product Catalog:

9
9 Publications Verification
Cat. No.: HY-114164H
CAS No.: 9002-04-4
Synonyms: EC 3.4.21.5 (Lyophilized); Human Alpha Thrombin (Lyophilized)
Human α-Thrombin (EC 3.4.21.5; Human Alpha Thrombin) (Lyophilized) is a terminal serine protease in the coagulation cascade, as well as a potent physiological platelet agonist and fibrin-generating enzyme in vivo. Human α-Thrombin catalyzes the conversion of fibrinogen to fibrin for blood clot formation, and activates platelet aggregation by cleaving the protease-activated receptors PAR1 (major) (Kd = 1 nM) and PAR4 (minor) on the platelet surface to expose tethered ligands. Human α-Thrombin also amplifies coagulation via positive feedback by activating coagulation factors V, VIII, XI (FV/FVIII/FXI), and switches to activate protein C to exert anticoagulant effects after binding to thrombomodulin .
This product is in a freeze-dried form.
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6
6 Cited Publications
Cat. No.: HY-P0078
CAS No.: 141136-83-6
Synonyms: PAR-1 Agonist peptide; Thrombin Receptor Activator Peptide 6
TRAP-6 (PAR-1 agonist peptide), a peptide fragment, is a selective protease activating receptor 1 (PAR1) agonist. TRAP-6 activates human platelets via the thrombin receptor. TRAP-6 shows no activity at PAR4 .
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3
3 Cited Publications
Cat. No.: HY-P0226
CAS No.: 197794-83-5
TFLLR-NH2 is a selective PAR1 agonist with an EC50 of 1.9 μM.
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3
3 Cited Publications
Cat. No.: HY-P0226A
CAS No.: 1313730-19-6
Research Areas:  

Others

TFLLR-NH2 (TFA) is a selective PAR1 agonist with an EC50 of 1.9 μM.
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2
2 Cited Publications
Cat. No.: HY-P1309
CAS No.: 352017-71-1
Synonyms: PAR-4-AP; AY-NH2
PAR-4 Agonist Peptide, amide (PAR-4-AP; AY-NH2) is a proteinase-activated receptor-4 (PAR-4) agonist, which has no effect on either PAR-1 or PAR-2 and whose effects are blocked by a PAR-4 antagonist.
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2
2 Cited Publications
Cat. No.: HY-P1309A
CAS No.: 1228078-65-6
Synonyms: PAR-4-AP TFA; AY-NH2 TFA
PAR-4 Agonist Peptide, amide TFA (PAR-4-AP TFA; AY-NH2 TFA) is a proteinase-activated receptor-4 (PAR-4) agonist, which has no effect on either PAR-1 or PAR-2 and whose effects are blocked by a PAR-4 antagonist .
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Cat. No.: HY-P2518
CAS No.: 141136-85-8
Protease-Activated Receptor-1, PAR-1 Agonist is a selective proteinase-activated receptor1 (PAR-1) agonist peptide. Protease-Activated Receptor-1, PAR-1 Agonist corresponds to PAR1 tethered ligand and which can selectively mimic theactions of thrombin via this receptor .
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Cat. No.: HY-P5360
CAS No.: 244095-36-1
Research Areas:  

Others

TFLLRN-NH2 is a biological active peptide. (PAR-1 Agonist)
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Cat. No.: HY-P2321
CAS No.: 141923-40-2
TRAP-6 amide is a PAR-1 thrombin receptor agonist peptide .
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Cat. No.: HY-P5372A
Research Areas:  

Cancer

Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2 TFA, a bioactive peptide, is a selective Protease activating receptor 1 (PAR-1) agonist over PAR-2. PAR-1 belongs to a subfamily of G-protein coupled receptors and is known to mediate the cellular effects of thrombin. In addition to its varied cellular effects of thrombin, PAR-1 has also been shown to coordinate with PAR-4 and regulate thrombin-induced hepatocellular carcinoma harboring thrombin formation within the tumor environment classified as 'coagulation type' .
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Cat. No.: HY-P5001
CAS No.: 150242-29-8
Synonyms: iso-SFLLRN
iso-TRAP-6 (iso-SFLLRN) is a PAR-1 agonist that can activate platelets. iso-TRAP-6 is an analog of TRAP-6 (HY-P0078) that refers to the use of isoserine instead of serine as first amino acid .
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Cat. No.: HY-P2518A
Research Areas:  

Cancer

Protease-Activated Receptor-1, PAR-1 Agonist TFA is a selective proteinase-activated receptor1 (PAR-1) agonist peptide. Protease-Activated Receptor-1, PAR-1 Agonist TFA corresponds to PAR1 tethered ligand and which can selectively mimic theactions of thrombin via this receptor .
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Cat. No.: HY-P5358
CAS No.: 149440-16-4
Research Areas:  

Others

YFLLRNP is a biological active peptide. (a partial agonist of PAR-1. YFLLRNP selectively active G12/13 signaling pathway without activating Gq or Gi pathways at low concentrations. YFLLRNP (60 μM))
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Cat. No.: HY-P5372
CAS No.: 211190-38-4
Research Areas:  

Cancer

Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2, a bioactive peptide, is a selective Protease activating receptor 1 (PAR-1) agonist over PAR-2. PAR-1 belongs to a subfamily of G-protein coupled receptors and is known to mediate the cellular effects of thrombin. In addition to its varied cellular effects of thrombin, PAR-1 has also been shown to coordinate with PAR-4 and regulate thrombin-induced hepatocellular carcinoma harboring thrombin formation within the tumor environment classified as 'coagulation type' .
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Cat. No.: HY-P2321A
CAS No.: 1426807-16-0
TRAP-6 amide TFA is a PAR-1 thrombin receptor agonist peptide .
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Cat. No.: HY-P1261
CAS No.: 1065756-01-5
Parstatin(mouse), a cell-penetrating PAR-1 thrombin receptor agonist peptide, is a potent inhibitor of angiogenesis .
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Cat. No.: HY-P1262
CAS No.: 1065755-99-8
Parstatin(human), a cell-penetrating PAR-1 thrombin receptor agonist peptide, is a potent inhibitor of angiogenesis .
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Cat. No.: HY-P1261A
Parstatin(mouse) TFA, a cell-penetrating PAR-1 thrombin receptor agonist peptide, is a potent inhibitor of angiogenesis .
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Cat. No.: HY-P1262A
Parstatin(human) TFA, a cell-penetrating PAR-1 thrombin receptor agonist peptide, is a potent inhibitor of angiogenesis .
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Cat. No.: HY-P5371
CAS No.: 145229-90-9
Target:  

Thrombin

Research Areas:  

Others

TFLLRNPNDK-NH2 is a biological active peptide. (This peptide is a thrombin receptor activating peptide. This PAR-1 agonist peptide reversibly binds to PAR-1 mimicking the 'tethered ligand' that thrombin makes available through proteolytic cleavage of substrate. It is also known to cause increase in liquid and protein permeability much like thrombin.)
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