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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
7 Results for "
PDIA4
" in MedChemExpress (MCE) Product Catalog:
Products (7)
7 Results for "PDIA4" in MCE Product Catalog:
2
2 Cited Publications
E64FC26 is a potent pan-inhibitor of the protein disulfide isomerase (PDI) family, with IC50s of 1.9, 20.9, 25.9, 16.3, and 25.4 μM against PDIA1, PDIA3, PDIA4, TXNDC5, and PDIA6, respectively. E64FC26 shows anti-myeloma activity .
(E/Z)-E64FC26 is a mixture of the stereoisomers E-E64FC26 and Z-E64FC26, in which E-E64FC26 is the active component and acts as a potent PDI inhibitor. The IC50 values of E64FC26 (E-E64FC26) for PDIA1, PDIA3, PDIA4, TXNDC5, and PDIA6 are 0.6, 4.8, 33.1, 12.1, and 5.7 μM, respectively. By inhibiting PDI, (E/Z)-E64FC26 causes massive intracellular accumulation of misfolded polyubiquitinated proteins, thereby triggering strong endoplasmic reticulum stress and oxidative stress responses, which in turn induce apoptosis. (E/Z)-E64FC26 is used in research on multiple myeloma, ovarian cancer, and breast cancer [4].
Cat. No.: HY-RS10269
Target:
Research Areas:
PDIA4 Human Pre-designed siRNA Set A contains three designed siRNAs for PDIA4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS17554
Target:
Research Areas:
Pdia4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pdia4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS24012
Target:
Research Areas:
Pdia4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Pdia4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P71113
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PDIA4; ER Protein 72; Protein Disulfide Isomerase Family A Member 4; ERp-72; ERP70; Protein Disulfide Isomerase Related Protein (Calcium-Binding Protein, Intestinal-Related); ERP72; Protein Disulfide Isomerase Family A, Member 4; Endoplasmic Reticulum Res
Species:
Human
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
