Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
7 Results for "
PFKL
" in MedChemExpress (MCE) Product Catalog:
Products (7)
7 Results for "PFKL" in MCE Product Catalog:
Cat. No.: HY-RS25270
Target:
Domaines de recherche:
Pfkl Rat Pre-designed siRNA Set A contains three designed siRNAs for Pfkl gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS10365
Target:
Domaines de recherche:
PFKL Human Pre-designed siRNA Set A contains three designed siRNAs for PFKL gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS18781
Target:
Domaines de recherche:
Pfkl Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pfkl gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-187532
Target:
Domaines de recherche:
PFKL-IN-1 is an orally active PFKL inhibitor, with a human-derived IC50 value of 52.63 nM and a Kd of 0.24 μM. PFKL-IN-1 directly binds to PFKL and inhibits its enzymatic activity. PFKL-IN-1 inhibits glycolysis, induces apoptosis and suppresses cell proliferation in breast cancer cells. PFKL-IN-1 exhibits antitumor efficacy in mouse models and enhances the therapeutic effect of anti-PD-L1 agents. PFKL-IN-1 can be used in breast cancer-related research .
Cat. No.: HY-189236
CAS No.: 3111620-80-2
Domaines de recherche:
XJ-4-85 is a covalent activator and precursor compound targeting PFKL (EC50=56 μM in human PFKL). XJ-4-85 activates glycolysis, increases FBP production and glycolytic flux, and enhances LPS-stimulated proinflammatory cytokine release in macrophages. XJ-4-85 causes long-chain acylcarnitine accumulation, metabolic stress, and cytotoxicity through the release of the active payload XJ-4-119 targeting CPT2. XJ-4-85 exhibits broad and selective cytotoxicity across multiple cancer cell lines and is useful for melanoma research .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
