PI3K/Akt/Nrf2

Infection Alkaloids Piperidine Alkaloids Leguminosae Plants Sophora flavescens Aiton Disease Research Fields Inflammation/Immunology

Autophagy Apoptosis NF-κB PI3K Akt MEK ERK PTEN

Infection Alkaloids Piperidine Alkaloids Leguminosae Sophora japonica L. Plants Disease Research Fields Inflammation/Immunology

Autophagy Apoptosis NF-κB PI3K Akt MEK ERK

Plants Moraceae Endogenous metabolite Simple Phenylpropanols Other Diseases Phenols Polyphenols Phenylpropanoids Disease Research Fields Morus alba Linn.

Endogenous Metabolite NF-κB Keap1-Nrf2 mTOR HIF/HIF Prolyl-Hydroxylase

Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Inflammation/Immunology

Endogenous Metabolite Interleukin Related TNF Receptor AMPK Sirtuin STAT PI3K NF-κB JAK p38 MAPK JNK Akt Apoptosis Ferroptosis

Stilbenes Gnetum cleistostachyum C. Y. Cheng Gnetaceae Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology

Carnitine Palmitoyltransferase (CPT) Reactive Oxygen Species (ROS) Autophagy Apoptosis NF-κB PI3K Akt MMP Keap1-Nrf2

Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology

Interleukin Related TNF Receptor Endogenous Metabolite AMPK Sirtuin STAT PI3K NF-κB JAK p38 MAPK JNK Akt Apoptosis Ferroptosis

Liliaceae Flavonoids Flavonones Phenols Polyphenols Allium cepa L. Plants Disease Research Fields Inflammation/Immunology

Reactive Oxygen Species (ROS)

Flavonoids Flavones Campylotropis hirtella (Franch.) Schindl. Phenols Polyphenols Plants Compositae Disease Research Fields Inflammation/Immunology

COX Lipoxygenase NF-κB p38 MAPK ERK HIF/HIF Prolyl-Hydroxylase Keap1-Nrf2 PI3K Apoptosis Autophagy

Triterpenes other families Leguminosae Terpenoids Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Metabolic Disease Plants Disease Research Fields

Akt NF-κB p38 MAPK PI3K FXR Keap1-Nrf2 NO Synthase COX Interleukin Related Integrin TGF-β Receptor Reactive Oxygen Species (ROS)

Eucommia ulmoides Oliver Other Diseases Lignans Eucommiaceae Phenylpropanoids Plants Disease Research Fields

Free Radical Scavengers NF-κB Keap1-Nrf2 Heme Oxygenase (HO) TGF-beta/Smad Akt mTOR PI3K

Paeonia lactiflora Pall. Other Diseases Phenols Polyphenols Plants Paeoniaceae Disease Research Fields

NF-κB ERK JNK Nuclear Factor of activated T Cells (NFAT) Keap1-Nrf2 PI3K Akt Reactive Oxygen Species (ROS) Apoptosis DNA/RNA Synthesis

Cardiovascular Disease Triterpenes other families Terpenoids Plants Disease Research Fields

Apoptosis PARP Caspase AMPK Autophagy VEGFR Keap1-Nrf2 STING 11β-HSD Ferroptosis PI3K Akt p38 MAPK ERK

Natural Products Metabolic Disease Endogenous metabolite Disease Research Fields

PI3K Akt mTOR Ferroptosis Apoptosis Autophagy Glutathione Peroxidase Keap1-Nrf2

other families Ketones, Aldehydes, Acids Plants Disease Research Fields Cancer

Apoptosis NF-κB NOD-like Receptor (NLR) STAT PI3K Akt Hedgehog GSK-3 p38 MAPK ERK JNK Keap1-Nrf2 Reactive Oxygen Species (ROS) Autophagy

Inflammation/Immunology

Ketones, Aldehydes, Acids Ranunculaceae Plants

NO Synthase Prostaglandin Receptor PI3K Akt NF-κB Keap1-Nrf2 COX

Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite

Reference Standards Endogenous Metabolite Interleukin Related TNF Receptor AMPK Sirtuin STAT PI3K NF-κB JAK p38 MAPK JNK Akt Apoptosis Ferroptosis

Apocynaceae Alkaloids Piperidine Alkaloids Tabernaemontana bufalina Lour. Plants

TREM receptor Toll-like Receptor (TLR) MyD88 NF-κB Keap1-Nrf2 Heme Oxygenase (HO) TNF Receptor Interleukin Related p38 MAPK PI3K Akt Reactive Oxygen Species (ROS)

Natural Products Endogenous metabolite

Interleukin Related TNF Receptor Endogenous Metabolite Reference Standards AMPK Sirtuin STAT PI3K NF-κB JAK p38 MAPK JNK Akt Apoptosis Ferroptosis

Metabolic Disease