882-33-7
Chemical Structure
Diphenyl disulfide
Synonym(s): Phenyl disulfide
- CAS No.: 882-33-7
- Formula:C12H10S2
- Molecular Weight:218.35
IUPAC Name: 1,2-diphenyldisulfane
InChIKey: GUUVPOWQJOLRAS-UHFFFAOYSA-N
SMILES: C1(SSC2=CC=CC=C2)=CC=CC=C1
Biological Activity: Diphenyl disulfide (Phenyl disulfide) is an organic disulfide compound. Diphenyl disulfide inhibits the PI3K/AKT/mTOR pathway, and induces ferroptosis (ferroptosis), apoptosis (apoptosis) and autophagy (autophagy) in cancer cells. Diphenyl disulfide downregulates GPX4 expression, inhibits NRF2 phosphorylation, induces lipid peroxidation, promotes xCT ubiquitination, induces proteolytic cleavage of p21 Bax into p18 Bax, and suppresses cell proliferation and viability. Diphenyl disulfide can be used in research related to melanoma and breast cancer[1][2][3].
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Diphenyl disulfide | 99.96% | Diphenyl disulfide (Phenyl disulfide) is an organic disulfide compound. Diphenyl disulfide inhibits the PI3K/AKT/mTOR pathway, and induces ferroptosis (ferroptosis), apoptosis (apoptosis) and autophagy (autophagy) in cancer cells. Diphenyl disulfide downregulates GPX4 expression, inhibits NRF2 phosphorylation, induces lipid peroxidation, promotes xCT ubiquitination, induces proteolytic cleavage of p21 Bax into p18 Bax, and suppresses cell proliferation and viability. Diphenyl disulfide can be used in research related to melanoma and breast cancer. | ||||||||||||||||||||
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Diphenyl disulfide (Standard) | ≥98% | Diphenyl disulfide (Standard) is an analytical standard for diphenyl disulfide (HY-Y1177). This product is intended for research and analytical applications. Diphenyl disulfide (Phenyl disulfide) is an organic disulfide compound. Diphenyl disulfide inhibits the PI3K/AKT/mTOR pathway, and induces ferroptosis (ferroptosis), apoptosis (apoptosis) and autophagy (autophagy) in cancer cells. Diphenyl disulfide downregulates GPX4 expression, inhibits NRF2 phosphorylation, induces lipid peroxidation, promotes xCT ubiquitination, induces proteolytic cleavage of p21 Bax into p18 Bax, and suppresses cell proliferation and viability. Diphenyl disulfide can be used in research related to melanoma and breast cancer. | ||||||||||||||||||||
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- [1]. Chen SY, et al. Diphenyl Disulfide Exerts Dual Cytotoxic Effects by Inducing Ferroptosis and Apoptosis in Melanoma Cells. Arch Immunol Ther Exp (Warsz). 2025;74(1):10.2478/aite-2026-0007. Published 2025 Dec 20. [Content Brief]
- [2]. Chen SY, et al. Diphenyl disulfide potentiates the apoptosis of breast cancer cells through Bax proteolytic activation with accompanying autophagy. Environ Toxicol. 2023;38(8):2022-2030. [Content Brief]
- [3]. Graebin A, et al. Nasturtium leaf compounds, diphenyl disulfide and lyral, against Atta sexdens (Hymenoptera: Formicidae) and their symbiotic fungi. J Econ Entomol. 2024;117(5):1703-1711. [Content Brief]
