882-33-7
882-33-7
Chemical Structure
Diphenyl disulfide
Synonym(s): Phenyl disulfide
- CAS. Nr.: 882-33-7
- Formula:C12H10S2
- Molecular Weight:218.35
IUPAC Name: 1,2-diphenyldisulfane
InChIKey: GUUVPOWQJOLRAS-UHFFFAOYSA-N
SMILES: C1(SSC2=CC=CC=C2)=CC=CC=C1
Biological Activity: Diphenyl disulfide (Phenyl disulfide) is an organic disulfide compound. Diphenyl disulfide inhibits the PI3K/AKT/mTOR pathway, and induces ferroptosis (ferroptosis), apoptosis (apoptosis) and autophagy (autophagy) in cancer cells. Diphenyl disulfide downregulates GPX4 expression, inhibits NRF2 phosphorylation, induces lipid peroxidation, promotes xCT ubiquitination, induces proteolytic cleavage of p21 Bax into p18 Bax, and suppresses cell proliferation and viability. Diphenyl disulfide can be used in research related to melanoma and breast cancer[1][2][3].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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Diphenyl disulfide | 99.96% | Diphenyl disulfide (Phenyl disulfide) is an organic disulfide compound. Diphenyl disulfide inhibits the PI3K/AKT/mTOR pathway, and induces ferroptosis (ferroptosis), apoptosis (apoptosis) and autophagy (autophagy) in cancer cells. Diphenyl disulfide downregulates GPX4 expression, inhibits NRF2 phosphorylation, induces lipid peroxidation, promotes xCT ubiquitination, induces proteolytic cleavage of p21 Bax into p18 Bax, and suppresses cell proliferation and viability. Diphenyl disulfide can be used in research related to melanoma and breast cancer. | ||||||||||||||||||||
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Diphenyl disulfide (Standard) | ≥98% | Diphenyl disulfide (Standard) is an analytical standard for diphenyl disulfide (HY-Y1177). This product is intended for research and analytical applications. Diphenyl disulfide (Phenyl disulfide) is an organic disulfide compound. Diphenyl disulfide inhibits the PI3K/AKT/mTOR pathway, and induces ferroptosis (ferroptosis), apoptosis (apoptosis) and autophagy (autophagy) in cancer cells. Diphenyl disulfide downregulates GPX4 expression, inhibits NRF2 phosphorylation, induces lipid peroxidation, promotes xCT ubiquitination, induces proteolytic cleavage of p21 Bax into p18 Bax, and suppresses cell proliferation and viability. Diphenyl disulfide can be used in research related to melanoma and breast cancer. | ||||||||||||||||||||
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Diphenyl sulfone | Diphenyl sulfone (compound 10a) is a 5-HT6R antagonist with a Ki of 1.6 μM. | |||||||||||||||||||||
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Azobenzene (Standard) | ≥98% | Azobenzene (Standard) is the analytical standard of Azobenzene. This product is intended for research and analytical applications. Azobenzene can be used as an optical trigger for the design and synthesis of a large variety of photoresponsive systems. | ||||||||||||||||||||
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Diphenylamine hydrochloride | 99.92% | Diphenylamine hydrochloride (N-Phenylaniline hydrochloride) is an antihyperglycemic agent with oral activity and a common structure in non-steroidal anti-inflammatory drugs (NSAIDs) that uncouples oxidative phosphorylation in mitochondria, leading to a decrease in hepatic cell ATP levels and causing liver cell damage. Diphenylamine hydrochloride is also an industrial antioxidant, a dyeing mordant, and is used in agriculture as an antifungal and antibacterial agent. | ||||||||||||||||||||
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Diphenylmethane | 99.99% | Diphenylmethane (Benzylphenyl) is an aromatic compound used as a drug intermediate. Diphenylmethane in the fragrance industry is used as an oxidizing agent and in soaps; in pesticides, as a synergist; and in dyes, as a plasticizer. | ||||||||||||||||||||
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1,2-Di(pyridin-4-yl)disulfane | 98.46% | 1,2-Di(pyridin-4-yl)disulfane (Aldrithiol(tm)-4) is a metal-organic framework (MOF). | ||||||||||||||||||||
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Diphenyl sulfide | 99.71% | Diphenyl sulfide is an additive for organic photovoltaic devices. Diphenyl sulfide modulates vertical composition distribution of PTB7-Th:PC71BM photoactive layers, promoting enrichment of PTB7-Th at the upper surface and PC71BM at the bottom. Diphenyl sulfide promotes ordered molecular packing and crystallinity of PTB7-Th:PC71BM photoactive layers, including more compact π−π stacking of PTB7-Th. Diphenyl sulfide improves exciton dissociation, charge transport, and charge collection in PTB7-Th:PC71BM-based inverted polymer solar cells. Diphenyl sulfide acts as a solvent additive to improve the photovoltaic performance of inverted organic photovoltaic devices. | ||||||||||||||||||||
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Diphenyliodonium iodide | 98.0% | Diphenyliodonium iodide is an inhibitor of reactive oxygen species (ROS). Diphenyliodonium iodide can inhibit the accumulation of bisdemethoxycurcumin in fresh-cut yam by inhibiting the phenylpropanoid pathway and the biosynthesis of bisdemethoxycurcumin, thereby preventing the yellowing of fresh-cut yam. Diphenyliodonium iodide can be used in medicine and fruit preservation. | ||||||||||||||||||||
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Diphenyl ether-13C12 | Diphenyl ether-13C12 is 13C labeled Diphenyl ether. Oxydibenzene is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | |||||||||||||||||||||
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2,2′-Dipyridyl disulfide | 99.89% | 2,2′-Dipyridyl disulfide is a useful reagent for the determination of sulfhydryl groups. 2,2′-Dipyridyl disulfide is a common reagent in peptide chemistry, often used in oxidation–reduction condensations to form peptide bonds or in coupling reactions to form disulfide-linked heterodimers. | ||||||||||||||||||||
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References
- [1]. Chen SY, et al. Diphenyl Disulfide Exerts Dual Cytotoxic Effects by Inducing Ferroptosis and Apoptosis in Melanoma Cells. Arch Immunol Ther Exp (Warsz). 2025;74(1):10.2478/aite-2026-0007. Published 2025 Dec 20. [Content Brief]
- [2]. Chen SY, et al. Diphenyl disulfide potentiates the apoptosis of breast cancer cells through Bax proteolytic activation with accompanying autophagy. Environ Toxicol. 2023;38(8):2022-2030. [Content Brief]
- [3]. Graebin A, et al. Nasturtium leaf compounds, diphenyl disulfide and lyral, against Atta sexdens (Hymenoptera: Formicidae) and their symbiotic fungi. J Econ Entomol. 2024;117(5):1703-1711. [Content Brief]
