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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
4 Results for "
PNPLA3 I148M
" in MedChemExpress (MCE) Product Catalog:
Products (4)
4 Results for "PNPLA3 I148M" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-P704076
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: PNPLA3; Calcium-Independent Phospholipase A2-Epsilon; Prev. C22orf20; Acylglycerol Transacylase; Prev. ADPN; IPLA2-Epsilon; Adiponutrin; DJ796I17.1; Patatin Like Domain 3, 1-Acylglycerol-3-Phosphate O-Acyltransferase; FLJ22012; Patatin-Like Phospholipase
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-163959
CAS No.: 3036158-98-9
Target:
Research Areas:
PF-07853578 is an orally active PNPLA3 modulator. PF-07853578 significantly reduces human PNPLA3-I148M protein levels and effectively decreases hepatic triglyceride content by reducing this mutant protein. PNPLA3 degrader-1 can be used in the research of liver cirrhosis and hepatocellular carcinoma .
Cat. No.: HY-173599
Target:
Research Areas:
NUV-244 is a molecular glue degrader of PNPLA3 I148M. NUV-244 induces degradation via the ubiquitin-proteasome system involving the E3 ligase BFAR. NUV-244 promotes 26S proteasome-dependent degradation of PNPLA3 I148M. NUV-244 restores lipid droplet morphology and cellular fitness in hepatocytes expressing PNPLA3 I148M. NUV-244 can be used in the research of metabolic dysfunction-associated fatty liver disease .
Cat. No.: HY-P704075
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: PNPLA3; Calcium-Independent Phospholipase A2-Epsilon; Prev. C22orf20; Acylglycerol Transacylase; Prev. ADPN; IPLA2-Epsilon; Adiponutrin; DJ796I17.1; Patatin Like Domain 3, 1-Acylglycerol-3-Phosphate O-Acyltransferase; FLJ22012; Patatin-Like Phospholipase
Species:
Human
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
