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TRPV4 channel

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By Targets:	Calcium Channel (2) Endogenous Metabolite (2) Potassium Channel (1) Reference Standards (1) TRP Channel (15)
By Research Areas:	Cancer (5) Cardiovascular Disease (6) Inflammation/Immunology (3) Metabolic Disease (6) Neurological Disease (4)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-19608

GSK1016790A Maximum Cited Publications 38 Publications Verification	TRP Channel Calcium Channel	Cardiovascular Disease Metabolic Disease
GSK1016790A is a potent and selective transient receptor potential vanilloid 4 (TRPV4) channel agonist. GSK1016790A can elicit Ca ²⁺ influx and elevate intracellular Ca ²⁺ in HEK cells .

HY-19975

RN-1734 5+ Cited Publications	TRP Channel	Neurological Disease Cancer
RN-1734 is selective antagonist of the **TRPV4 channel*, completely antagonizes 4αPDD-mediated activation of TRPV4* with comparable, low micromolar IC₅₀s for all three species (hTRPV4: 2.3 μM, mTRPV4: 5.9 μM, rTRPV4: 3.2 μM) . RN-1734 clearly decreases the production of tumor necrosis factor α (TNF-α) and interleukin 1β (IL-1β) without altering the number of olig2-positive cells .

HY-19765

GSK2798745 5+ Cited Publications	TRP Channel	Cardiovascular Disease
GSK2798745 is a potent, selective, and orally active transient receptor potential vanilloid 4 (TRPV4) ion channel blocker with IC₅₀s of 1.8 and 1.6 nM for hTRPV4 and rTRPV4, respectively. GSK2798745 can be used in cardiac and respiratory diseases research .

HY-101507

Zerencotrep 10+ Cited Publications Pico145; HC-608	TRP Channel	Cancer
Pico145 (HC-608) is a remarkable inhibitor of TRPC1/4/5 channels, inhibits (-)-englerin A-activated TRPC4/TRPC5 channels, with IC₅₀s of 0.349 and 1.3 nM in cells, and shows no effect on TRPC3, TRPC6, TRPV1, TRPV4, TRPA1, TRPM2, TRPM8 .

HY-18662

RQ-00203078 5+ Cited Publications	TRP Channel	Neurological Disease Cancer
RQ-00203078 is a highly selective, potent and orally active TRPM8 antagonist with IC₅₀s of 5.3 nM and 8.3 nM for rat and human TRPM8 channels, respectively. RQ-00203078 shows little inhibitory action against TRPV1, TRPA1, TRPV4, or TRPM2 channels .

HY-N8264

Moringin 1 Publications Verification	TRP Channel	Neurological Disease Inflammation/Immunology Cancer
Moringin is a potent and selective TRPA1 ion channel natural agonist with an EC₅₀ of 3.14 μM. Moringin does not activate or activates very weakly the vanilloids somatosensory channels TRPV1, TRPV2, TRPV3 and TRPV4, and the melastatin cooling receptor TRPM8. Moringin has hypoglycemic, antimicrobial, anti-inflammatory, anticancer and neuroprotection activities .

HY-157131

TRPV2-selective blocker 1 2 Publications Verification	TRP Channel	Neurological Disease
TRPV2-selective blocker 1 is a TRPV2-selective blocker that inhibits calcium influx and ionic currents. TRPV2-selective blocker 1 exhibits an IC₅₀of 6.3 μM against rat *TRPV2, and shows no activity against TRPV1, TRPV3* or *TRPV4* channels. TRPV2-selective blocker 1 attenuates macrophage phagocytosis, LPS-induced macrophage migration, and calcium microdomains generated by peripheral *TRPV2. TRPV2-selective blocker 1 is non-cytotoxic and can be used to investigate the function of TRPV2* during immune processes .

HY-19976

RN-1747 5 Publications Verification	TRP Channel	Cardiovascular Disease Metabolic Disease
RN-1747 is a selective *TRPV4* channel agonist, with EC₅₀ values of 0.77 μM, 4.0 μM and 4.1 μM for hTRPV4, mTRPV4 and rTRPV4, respectively. RN-1747 acts as an antagonist of TRPM8, with an IC₅₀ of 4 μM. Topical cutaneous administration of RN-1747 induces hypothermia, increases tail heat loss via cutaneous vasodilation, and promotes cold-seeking behavior in rats. Intracerebroventricular administration of RN-1747 does not induce hypothermia in rats .

HY-120963

N-Oleoyl Taurine	Endogenous Metabolite	Metabolic Disease
Several different arachidonoyl amino acids, including N-arachidonoyl dopamine and N-arachidonoyl serine, have been isolated and characterized from bovine brain.1 During mass spectral lipidomics analysis of rat brain, a series of fatty acyl amides of a third amino acid, taurine, were discovered.2 This novel class of compounds is present in kidney and activates members of the transient receptor potential (TRP) family of calcium channels.3 N-Oleoyl taurine is an amino-acyl endocannabinoid isolated from rat brain that may activate TRPV1 and TRPV4.

HY-110270

RN-9893	TRP Channel	Inflammation/Immunology
RN-9893 is a potent and selective TRPV4 receptor antagonist with IC₅₀ values of 320, 420 and 660 nM for mouse, human and rat channels, respectively .

HY-126720

N-Lignoceroyl Taurine	Endogenous Metabolite	Metabolic Disease
N-Lignoceroyl Taurine is an arachidonoyl amino acid and taurine conjugate with a fatty acid that can be isolated from bovine brain. N-Lignoceroyl Taurine is one of several novel taurine-conjugated fatty acids discovered during mass spectrometry lipidomic analysis of the brain and spinal cord of wild-type and fatty acid amide hydrolase (FAAH) knockout mice. N-Lignoceroyl Taurine levels were 23-26-fold higher in FAAH ^-/- mice compared to wild-type mice, suggesting that FAAH utilizes N-Lignoceroyl Taurine as a substrate. However, in vitro experiments with purified FAAH showed that N-Lignoceroyl Taurine was hydrolyzed 2,000-fold slower in FAAH compared to oleoylethanolamide. N-Acyl Taurines with polyunsaturated acyl chains can activate members of the transient receptor potential (TRP) calcium channel family, including TRPV1 and TRPV4.

HY-178236

TRPM5 agonist-1	TRP Channel	Metabolic Disease
TRPM5 agonist-1 is an orally active TRPM5 agonist with a pEC₅₀ of 8.1. TRPM5 agonist-1 shows excellent selectivity (> 100-fold) versus related cation channels (TRPM8, TRPV1, TRPV4, TRPA1, TRPM4). TRPM5 agonist-1 exhibits locally acting stimulatory effect on gastrointestinal transit in mice. TRPM5 agonist-1 can be used for research on promoting gastric motility .

HY-N2940

Bisandrographolide A BAA	TRP Channel	Cardiovascular Disease Inflammation/Immunology
Bisandrographolide A (BAA) activates **TRPV4 channel with an EC₅₀** of 790-950 nM. Bisandrographolide A can bind to CD81 and suppress its function. Bisandrographolide A is an anti-inflammatory, immunostimulant, and antihypertensive compound .

HY-120514

JNc-440	TRP Channel Potassium Channel	Cardiovascular Disease
JNc-440 is a potent antihypertensive agent. JNc-440 can enhance the interaction of *TRPV4* and Ca ²⁺-activated potassium channel 3 (KCa2.3) in endothelial cells. JNc-440 can also enhance vasodilation, and exerted antihypertensive effects in mice .

HY-183906

GSK3491943	TRP Channel	Cardiovascular Disease
GSK3491943 is an antagonist of the transient receptor potential vanilloid subtype 4 (TRPV4) ion channel. GSK3491943 is applicable to research related to pulmonary edema induced by heart failure .

HY-186172

KS0365	TRP Channel Calcium Channel	Metabolic Disease
KS0365 is a selective *TRPV3* agonist with an EC₅₀ of 5.08 μM. KS0365 does not activate TRPV2 or TRPV4 channels. KS0365 triggers an increase in [Ca ²⁺]_i and accelerates keratinocyte migration. KS0365 can be used in studies related to impaired skin wound healing .

HY-101507R

Zerencotrep (Standard) Pico145 (Standard); HC-608 (Standard)	TRP Channel Reference Standards	Cancer
Zerencotrep (Standard) is the analytical standard of Zerencotrep (HY-101507). This product is intended for research and analytical applications. Pico145 (HC-608) is a remarkable inhibitor of TRPC1/4/5 channels, inhibits (-)-englerin A-activated TRPC4/TRPC5 channels, with IC50s of 0.349 and 1.3 nM in cells, and shows no effect on TRPC3, TRPC6, TRPV1, TRPV4, TRPA1, TRPM2, TRPM8 .

Moringin 1 Publications Verification	Structural Classification Natural Products Neurological Disease Classification of Application Fields Moringa oleifera Lam. Moringaceae Plants Inflammation/Immunology Disease Research Fields Source Classification	TRP Channel
Moringin is a potent and selective TRPA1 ion channel natural agonist with an EC₅₀ of 3.14 μM. Moringin does not activate or activates very weakly the vanilloids somatosensory channels TRPV1, TRPV2, TRPV3 and TRPV4, and the melastatin cooling receptor TRPM8. Moringin has hypoglycemic, antimicrobial, anti-inflammatory, anticancer and neuroprotection activities .

Bisandrographolide A BAA	Structural Classification Acanthaceae Simsia foetida (Cav.) S.F.Blake Terpenoids Diterpenoids Plants Source Classification	TRP Channel
Bisandrographolide A (BAA) activates **TRPV4 channel with an EC₅₀** of 790-950 nM. Bisandrographolide A can bind to CD81 and suppress its function. Bisandrographolide A is an anti-inflammatory, immunostimulant, and antihypertensive compound .

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P810993

	TRPV4 Antibody VRL2, VROAC, TRPV4, Transient receptor potential cation channel subfamily V member 4, TRPV4, Osm-9-like TRP channel 4, Transient receptor potential protein 12, Vanilloid receptor-like channel 2, Vanilloid receptor-like protein 2, Vanilloid receptor-related osmotically-activated channel, OTRPC4, TRP12, VRL-2, VR-OAC	WB, ICC/IF	Human, Mouse, Rat
	TRPV4 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to TRPV4.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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TRPV4 channel

Inhibitors & Agonists

NaturalProducts

Antibodies

Natural
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