2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel Calcium Channel
  4. KS0365

KS0365 is a selective TRPV3 agonist with an EC50 of 5.08 μM. KS0365 does not activate TRPV2 or TRPV4 channels. KS0365 triggers an increase in [Ca2+]i and accelerates keratinocyte migration. KS0365 can be used in studies related to impaired skin wound healing.

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KS0365

KS0365 Chemical Structure

CAS No. : 1689577-22-7

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KS0365 Related Antibodies

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Description

KS0365 is a selective TRPV3 agonist with an EC50 of 5.08 μM. KS0365 does not activate TRPV2 or TRPV4 channels. KS0365 triggers an increase in [Ca2+]i and accelerates keratinocyte migration. KS0365 can be used in studies related to impaired skin wound healing[1].

IC50 & Target[1]

TRPV3

5.08 μM (EC50)

In Vitro

KS0365 (0.1-100 μM; 20 μM primary screen; 10 μM validation) potently and selectively activates recombinant mouse TRPV3 in HEKmTRPV3-CFP cells with an EC50 of 5.08 μM, inducing sustained [Ca2+]ᵢ increases without significant off-target effects at 10 μM[1].
KS0365 (0.8-12.5 μM HEK cells; 10-50 μM m308k cells; 24 h) induces TRPV3-dependent metabolic activity changes: it reduces metabolic activity in TRPV3-overexpressing HEKmTRPV3-CFP cells and causes a biphasic effect in m308k Mus musculus keratinocytes, with a TRPV3-mediated increase at 10 μM and off-target toxicity at 50 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

KS0365 Related Antibodies

Cell Viability Assay[1]

Cell Line: HEKmTRPV3-CFP cells, parental HEK293 cells, m308k mouse keratinocytes
Concentration: 0.8-12.5 μM (HEK cells); 10-50 μM (m308k cells)
Incubation Time: 24 h
Result: Caused a concentration-dependent decrease in metabolic activity in HEKmTRPV3-CFP cells, which was reversed by co-treatment with 10 μM ruthenium red.
Showed no decrease in metabolic activity in parental HEK293 cells.
Exhibited a biphasic effect in m308k cells: 10 μM and 25 μM slightly but significantly increased metabolic activity (126.5% and 107.8% of untreated control, respectively), while 50 μM drastically decreased metabolic activity.
Inhibited the pro-metabolic effect of 10 μM KS0365 by 10 μM ruthenium red, but effects of 25 μM and 50 μM KS0365 were unaffected by ruthenium red.
Molecular Weight

250.76

Formula

C15H19ClO
CAS No.
SMILES

ClC1=C(C(C)C)CCC1C2=CC(C)=CC=C2O
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Room temperature in continental US; may vary elsewhere.
Storage

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Purity & Documentation
References
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KS0365 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KS03651689577-22-7KS 0365KS-0365TRP ChannelCalcium ChannelTransient receptor potential channelsCa2+ channelsCa channelsHEKmTRPV3-CFP cellsionic currentsTRPA1HEK293 cellsm308k mouse keratinocytesEGFintracellular calciumskin wound healingkeratinocytesTRPV3Inhibitorinhibitorinhibit

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