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Tetracycline derivatives

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (5) Bacterial (6) DNA/RNA Synthesis (3) Reference Standards (1)
By Research Areas:	Infection (6) Inflammation/Immunology (1)

Targets Recommended: Amino Acid Derivatives

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13858A

Sarecycline hydrochloride 4 Publications Verification P-005672 hydrochloride	Antibiotic Bacterial DNA/RNA Synthesis	Infection
Sarecycline hydrochloride is an orally active narrow-spectrum tetracycline derivative antibiotic. Sarecycline hydrochloride has anti-inflammatory activity. Sarecycline hydrochloride inhibits the activity of Gram-positive bacteria and several types of keratobacterium acnes. Sarecycline hydrochloride interferes with tRNA accommodation and tethers mRNA to the 70S ribosome. Sarecycline hydrochloride can be used to study moderate to severe acne .

HY-106339

Lymecycline 1 Publications Verification Mucomycin	Bacterial	Infection Inflammation/Immunology
Lymecycline is a tetracycline derivative, with broad-spectrum antibacterial activity and also has anti-inflammatory property.

HY-B1366A

Meclocycline	Antibiotic Bacterial	Infection
Meclocycline is a tetracycline antibiotic with broad-spectrum antibacterial activities, preventing skin bacterial infections such as acne vulgarisis .

HY-108971

Demecycline	Antibiotic Bacterial	Infection
Demecycline, a tetracycline antibiotic, is the C6-demethylated derivative of Tetracycline (HY-A0107) against bacterial infections including pneumonia and other respiratory tract infections .

HY-16770

Sarecycline P-005672	Antibiotic Bacterial DNA/RNA Synthesis	Infection
Sarecycline is an orally effective narrow-spectrum tetracycline derivative antibiotic. Sarecycline has anti-inflammatory activity. Sarecycline inhibits the activity of Gram-positive bacteria and several types of keratobacterium acnes. Sarecycline interferes with tRNA accommodation and tethers mRNA to the 70S ribosome. Sarecycline can be used to study moderate to severe acne .

HY-13858AR

Sarecycline hydrochloride (Standard) P-005672 hydrochloride (Standard)	Reference Standards Antibiotic Bacterial DNA/RNA Synthesis	Infection
Sarecycline (hydrochloride) (Standard) is the analytical standard of Sarecycline (hydrochloride). This product is intended for research and analytical applications. Sarecycline hydrochloride is an orally active narrow-spectrum tetracycline derivative antibiotic. Sarecycline hydrochloride has anti-inflammatory activity. Sarecycline hydrochloride inhibits the activity of Gram-positive bacteria and several types of keratobacterium acnes. Sarecycline hydrochloride interferes with tRNA accommodation and tethers mRNA to the 70S ribosome. Sarecycline hydrochloride can be used to study moderate to severe acne .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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Tetracycline derivatives

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