Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
1 Result for "
Topoisomerase I-IN-25
" in MedChemExpress (MCE) Product Catalog:
Products (1)
1 Results for "Topoisomerase I-IN-25" in MCE Product Catalog:
Cat. No.: HY-189630
Target:
Topoisomerase PKA Epigenetic Reader Domain PI3K Akt mTOR Bcl-2 Family Apoptosis Mitochondrial Metabolism Reactive Oxygen Species (ROS)
Research Areas:
Topoisomerase I-IN-25 is a moderate inhibitor of Topoisomerase I-mediated DNA relaxation. Topoisomerase I-IN-25 inhibits the cAMP-PKA-CREB and PI3K-AKT-mTOR signaling pathways. Topoisomerase I-IN-25 downregulates Bcl-2, upregulates Bax, and induces Apoptosis, G2/M phase arrest, mitochondrial dysfunction, and reactive oxygen species accumulation. Topoisomerase I-IN-25 exhibits anticancer activity against hepatocellular carcinoma. Topoisomerase I-IN-25 can be used for research on hepatocellular carcinoma .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
