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Results for "

UBR1

" in MedChemExpress (MCE) Product Catalog:

2

Inhibitors & Agonists

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-RS15386
    UBR1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    UBR1 Human Pre-designed siRNA Set A contains three designed siRNAs for UBR1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    UBR1 Human Pre-designed siRNA Set A
    UBR1 Human Pre-designed siRNA Set A
  • HY-180976
    Arg-PEG1-Tαsyn

    		PROTACs α-synuclein Neurological Disease
    Arg-PEG1-Tαsyn is an α-syn PROTAC degrader with a DC50 of 0.28 μM in U251 cells. Arg-PEG1-Tαsyn employs the amino acid arginine (Arg) as the E3 ligase UBR1 ligand and a benzothiazole-aniline variant as the warhead for α-syn. Arg-PEG1-Tαsyn significantly reduces α-syn aggregates and improves the dopaminergic neuronal impairment and the locomotion with safety profile in vivo.Arg-PEG1-Tαsyn shows the high degradation effect in mammalian cells for both wild-type α-syn and the α-syn (A53T) mutant. Arg-PEG1-Tαsyn can be used for Parkinson’s disease research [1] .
    Arg-PEG1-Tαsyn

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